Abstract: A computerized method of transforming an interactive graphical user interface according to machine learning includes generating a user interface element corresponding to a persona. In response to user interaction with the user interface element, data structures related to the persona are extracted from a first data store. The data structures are transformed into a set of input variables. The method includes generating a first output variable based on the set of input variables. A second output variable based on the first input variable is generated by: generating a set of intermediate output variables, determining a first intermediate output variable of the set of intermediate output variables, and determining a second intermediate output variable based on a machine learning model corresponding to the first intermediate output variable. In response to the second output variable exceeding a first threshold, the graphical user interface displays a first message.

Abstract: The present invention provides a GPIO driver including a control logic, a level shifter module and a post-driver. The control logic supplied by a first supply voltage is configured to receive an input signal to generate a first signal. The level shifter module is configured to receive the first signal to generate a second signal. The post-driver supplied by a second supply voltage is configured to receive the second signal to generate an output signal. When the first supply voltage is lower than the second supply voltage, the level shifter module performs a level-boosting operation to increase a voltage level of the first signal to generate the second signal; and when the first supply voltage is greater than the second supply voltage, the level shifter module operates as a buffer, and the voltage level of the second signal is the same as the voltage level of the first signal.

Abstract: An interface device includes a dynamic tracking bias circuit, an ESD (Electrostatic Discharge) clamp circuit, a pre-driver, a post-driver, and an I/O (Input/Output) pad. The dynamic tracking bias circuit provides a first supply voltage. The first supply voltage is determined according to a main power voltage and a second supply voltage. The ESD clamp circuit limits the second supply voltage. The post-driver is driven by the pre-driver. The I/O pad is driven by the post-driver. The pre-driver and the post-driver are supplied by the main power voltage, the first supply voltage, and the second supply voltage.

Abstract: A computerized method of transforming an interactive graphical user interface according to machine learning includes generating a user interface element corresponding to a persona. In response to user interaction with the user interface element, data structures related to the persona are extracted from a first data store. The data structures are transformed into a set of input variables. The method includes generating a first output variable based on the set of input variables. A second output variable based on the first input variable is generated by: generating a set of intermediate output variables, determining a first intermediate output variable of the set of intermediate output variables, and determining a second intermediate output variable based on a machine learning model corresponding to the first intermediate output variable. In response to the second output variable exceeding a first threshold, the graphical user interface displays a first message.

Abstract: A computerized method of transforming an interactive graphical user interface according to machine learning includes generating a selectable user interface element corresponding to a persona. In response to a user selecting the user interface element, data structures related to the persona are extracted from a first data store. The data structures are transformed into a set of input variables at a data processing module and loaded at a model execution module. The model execution module generates a first output variable based on the set of input variables. An analysis module generates a second output variable based on the first input variable. The graphical user interface displays a first message, a second message, or a third message in response to conditions being met for the second output variable.

Abstract: A computerized method of transforming an interactive graphical user interface according to machine learning includes generating a selectable user interface element corresponding to a persona. In response to a user selecting the user interface element, data structures related to the persona are extracted from a first data store. The data structures are transformed into a set of input variables at a data processing module and loaded at a model execution module. The model execution module generates a first output variable based on the set of input variables. An analysis module generates a second output variable based on the first input variable. The graphical user interface displays a first message, a second message, or a third message in response to conditions being met for the second output variable.

Abstract: The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

Abstract: A detection kit is suitable for detecting a target compound. The detection kit includes a reaction container, an inspection solution composed of a hydrophobic solvent, and a plurality of fluorescent materials. The inspection solution is disposed in the reaction container. The fluorescent materials are dispersed in the inspection solution. The fluorescent material emits fluorescence, and after the fluorescent materials interact with the target compound, the intensity of the fluorescence emitted by the fluorescent materials is reduced.

Abstract: The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.

Abstract: An operation method for a DC/DC converter includes: using a power stage for converting a DC input voltage into a DC output voltage, the power stage including an inductor; detecting whether the DC output voltage has an overshoot when the DC/DC converter is switched from a heavy loading into a light loading; when it is determined that the DC output voltage has the overshoot, forcing the DC/DC converter for additionally maintaining at a force continuous conduction mode (CCM) and thus discharging the DC output voltage by the inductor, and controlling the DC/DC converter switching from the force CCM into a discontinuous conductor mode (DCM).

Abstract: A detection kit is suitable for detecting a target compound. The detection kit includes a reaction container, an inspection solution composed of a hydrophobic solvent, and a plurality of fluorescent materials. The inspection solution is disposed in the reaction container. The fluorescent materials are dispersed in the inspection solution. The fluorescent material emits fluorescence, and after the fluorescent materials interact with the target compound, the intensity of the fluorescence emitted by the fluorescent materials is reduced.

Abstract: The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

Abstract: The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.

Abstract: Provided is a control method for controlling a SIBO buck-boost converter including a first switch coupled between an input and a first node, a second switch coupled between the first node and GROUND, a third switch coupled between a second node and GROUND, a fourth switch coupled between the second node and a first output node for outputting the positive output, a fifth switch coupled between the first node and a second output node for outputting the negative output, and an inductor coupled between the first node and the second node. The first and the third switches are turned on to energize the inductor. The first and the fourth switches are turned on to generate a positive output. The third and the fifth switches are turned on to generate a negative output.

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, torroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia base-catalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract: In one aspect, the invention provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit single cell binding specificity to the substantial exclusion of non-targeted cells. For example, MSNPs and protocells of the invention may be used to target specific delivery of therapeutic agents to cancer cells or to specific blood vessel types (e.g. in the arterial, venous and/or capillary vessels or any combination of vessels). Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract: A waterproof speaker includes a speaker module and an elastic cover. The speaker module includes a sound generation unit, a control unit and a housing. The control unit is for controlling the sound generation unit to generate sound. The housing is for accommodating the sound generation unit and the control unit. The housing includes a sound emitting area formed with a plurality of through holes corresponding to the sound generation unit. The elastic cover includes a first part for covering outer surfaces of the housing other than the sound emitting area, and a second part for attaching the waterproof speaker to an object.