Patents by Inventor Yu-Sheng Chao

Yu-Sheng Chao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8486959
    Abstract: A group of novel dibenzo[f,h]isoquinoline derivatives as shown in the specification. Also disclosed are methods of using the compounds for treating a disease associated with NO overproduction, cancer, or viral infection.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: July 16, 2013
    Assignee: National Health Research Institutes
    Inventors: Shiow-Ju Lee, Cheng-Wei Yang, Yue-Zhi Lee, Yu-Sheng Chao
  • Patent number: 8415482
    Abstract: Compounds useful for treating hepatitis C virus infection. The compounds are of formula (I): wherein A, B, C, D, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, m, n, p, q, r, t, u, and v are defined herein. Also disclosed is a method for treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: April 9, 2013
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Yu-Sheng Chao
  • Publication number: 20130085126
    Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, and X are defined herein. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.
    Type: Application
    Filed: September 25, 2012
    Publication date: April 4, 2013
    Applicant: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chun-Ping Chang, Yu-Sheng Chao
  • Patent number: 8354442
    Abstract: Imidazol-4-one or imidazole-4-thione compounds of formula (I): wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. Also disclosed is a method for treating a cannabinoid receptor-mediated disorder with these compounds.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: January 15, 2013
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chien-Huang Wu, Teng-Kuang Yeh, Yu-Sheng Chao
  • Publication number: 20120225880
    Abstract: A compound of formula (I): wherein A, B, D, X, Y, R1, R2, R3, m, p, and q are defined herein. Also disclosed is a method for inhibiting FMS-like tyrosine kinase 3, aurora kinase, or vascular endothelial growth factor receptor.
    Type: Application
    Filed: March 1, 2012
    Publication date: September 6, 2012
    Applicant: National Health Research Institutes
    Inventors: Weir-Torn Jiaang, Tsu-An Hsu, Wen-Hsing Lin, Yu-Sheng Chao
  • Patent number: 8198284
    Abstract: A method for treating a neurodegenerative disorder. The method includes administering to a subject in need thereof an effective amount of one or more thiourea compounds of formula (I) or (II): Each variable in formula (I) or (II) is defined herein. Also disclosed is use of these thiourea compounds to reduce microglia-mediated neuro-inflammation or enhancing microglial phagocytosis of A?.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: June 12, 2012
    Assignee: National Health Research Institutes
    Inventors: Feng-Shiun Shie, Jyh-Haur Chern, Yu-Sheng Chao
  • Patent number: 8138194
    Abstract: Fused bicyclic pyrimidine compounds of formula (I): wherein R1, R3, R4, X1, X2, Y, Z, A, B, C, D, n, and the two bonds are defined herein. Also disclosed are a method for inhibiting Aurora kinase activity and a method for treating cancer with these compounds.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: March 20, 2012
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Selvaraj Mohane Coumar, Tsu-An Hsu, Su-Ying Wu, Yu-Sheng Chao
  • Publication number: 20120046238
    Abstract: A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a pharmaceutical composition including a coumarin compound.
    Type: Application
    Filed: November 10, 2011
    Publication date: February 23, 2012
    Applicant: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Jiann-Yih Yeh, Jim-Tong Horng, Shin-Ru Shih, Sui-yuan Chang, Yu-Sheng Chao
  • Patent number: 8058427
    Abstract: Coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a method for treating cancer with coumarin compounds.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: November 15, 2011
    Assignee: National Health Research Institutes
    Inventors: Hsing-Pang Hsieh, Jang-Yang Chang, Ching-Chuan Kuo, Yu-Sheng Chao
  • Patent number: 8048426
    Abstract: An invention relates to an extract of Chlorella sorokiniana, which contains myristic acid, palmitic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, and stearic acid. Also related is use of this extract to treat diabetes, obesity, and dyslipidaemia.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: November 1, 2011
    Assignee: International Chlorella Co., Ltd.
    Inventors: Hsing-Pang Hsieh, Tsu-An Hsu, Yu-Sheng Chao, Yu-Cheng Chou, Shun Te Wang
  • Publication number: 20110263620
    Abstract: Quinoline compounds of formula (I): in which A, B, D, E, F, G, R1, R2, R3, X, Y, n, p, and q are defined herein. Also disclosed is a method for treating a viral infection with a compound of formula (I).
    Type: Application
    Filed: April 21, 2011
    Publication date: October 27, 2011
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Hsing-Pang HSIEH, Tsu-An HSU, Jiann-Yih YEH, Yu-Sheng CHAO
  • Patent number: 8026271
    Abstract: This invention relates to an oral formulation containing an effective amount of the compound of the following formula I: d-alpha-tocopheryl polyethylene glycol 1000 succinate (“TPGS”); and 2-(2-ethoxyethoxy)ethanol (“Transcutol”). R1 through R4 and n are defined herein. Also disclosed is a method of treating cancer by administering this formula to a subject orally.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: September 27, 2011
    Assignee: National Health Research Institutes
    Inventors: Teng-Kuang Yeh, Chiung-Tong Chen, Yu-Sheng Chao
  • Patent number: 8022096
    Abstract: Pyrrolidine compounds described herein and methods for using them to inhibit dipeptidyl peptidase IV and treat Type II diabetes.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: September 20, 2011
    Assignee: National Health Research Institutes
    Inventors: Weir-Torn Jiaang, Yu-Sheng Chao, Ting-Yueh Tsai, Tsu Hsu
  • Patent number: 7985763
    Abstract: A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 26, 2011
    Assignee: National Health Research Institutes
    Inventors: Li-Wen Wang, Tsu-An Hsu, Yen-Chun Lee, Iou-Jiun Kang, Chung-Chi Lee, Yu-Sheng Chao, Jyh-Haur Chern
  • Publication number: 20110172261
    Abstract: A group of novel dibenzo[f,h]isoquinoline derivatives as shown in the specification. Also disclosed are methods of using the compounds for treating a disease associated with NO overproduction, cancer, or viral infection.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 14, 2011
    Applicant: National Health Research Institutes
    Inventors: Shiow-Ju Lee, Cheng-Wei Yang, Yue-Zhi Lee, Yu-Sheng Chao
  • Publication number: 20110136799
    Abstract: Compounds of formula (I): wherein A, B, C, D, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, m, n, p, q, r, t, u, and v are defined herein. Also disclosed is a method for treating hepatitis C virus infection with these compounds.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 9, 2011
    Applicant: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Yu-Sheng Chao
  • Patent number: 7939523
    Abstract: Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: May 10, 2011
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Sheng-Ju Hsu, Yueh Andrew Yueh, Yu-Sheng Chao
  • Patent number: 7897764
    Abstract: Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: March 1, 2011
    Assignee: National Health Research Institutes
    Inventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
  • Patent number: 7834046
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: November 16, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-shiu Hung, Yu-Sheng Chao
  • Patent number: 7803799
    Abstract: This invention relates to selenophene compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: September 28, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-Shan Shia, Jing-Po Tsao, Chia-Liang Tai, Wan-Ping Hsieh, Ming-Shiu Hung, Jen-Shin Song, Yu-Sheng Chao