Abstract: The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLpro activity, and is useful in the preparation of a SARS-CoV-2 3CLpro inhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLpro inhibitors and anti-SARS-CoV-2 drugs.

Abstract: A time-sensitive network control system and a centralized network configuration entity for controlling data traffic in the time-sensitive network control system.

Abstract: An integrated circuit (IC) with conductive structures and a method of fabricating the IC are disclosed. The method includes depositing a first dielectric layer on a semiconductor device, forming a conductive structure in the first dielectric layer, removing a portion of the first dielectric layer to expose a sidewall of the conductive structure, forming a barrier structure surrounding the sidewall of the conductive structure, depositing a conductive layer on the barrier structure, and performing a polishing process on the barrier structure and the conductive layer.

Abstract: A coating system for coating a substrate, comprises: a dosing unit for pre-weighing a solid material to be conveyed; a conveying unit for conveying the weighed solid material to the substrate to be coated by a conveying gas flow; a receiving unit for receiving the substrate and located downstream of the conveying unit along a flowing direction of the conveying gas flow; an automatic transfer mechanism for transferring the substrate to the receiving unit and removing the coated substrate out of the receiving unit; a control unit for controlling the operation of the dosing unit, the receiving unit and the automatic transfer mechanism; and a gas flow generating device for generating the conveying gas flow. A method of coating a substrate; with said coating system is also related.

Abstract: A coating system for coating a substrate, comprising: a dosing unit for pre-weighing and dosing a solid material to be conveyed; a conveying unit for conveying the weighed solid material to the substrate to be coated by a conveying gas flow; a receiving unit for receiving the substrate and located downstream of the conveying unit along a flowing direction of the conveying gas flow; and a control unit for controlling the operation of the dosing unit, the conveying unit and the receiving unit.

Abstract: A strip diverting mechanism includes a negative pressure unit and an air discharge unit. The negative pressure unit and the air discharge unit are arranged opposite each other, and a gap through which a strip passes is formed between the negative pressure unit and the air discharge unit. The negative pressure unit is configured to provide a suction force to the strip and the air discharge unit is configured to provide a repulsive force to the strip, to prevent the strip from contacting the negative pressure unit and the air discharge unit. The negative pressure unit comprises two air channels located at two sides of the negative pressure unit and configured to discharge air to a direction away from the negative pressure unit, to generate a negative pressure area at a center of the negative pressure unit.

Abstract: The present application is directed to a supported rare earth-catalyst. This catalyst comprises a metal oxide support having Brønsted acid sites and a rare earth element-catalyst. The rare earth element-catalyst is bound to the Brønsted acid sites on the metal oxide support. The present application is also directed to methods of making supported rare earth-catalyst and methods for borylation of hydrocarbons using the supported rare earth-catalyst.

Abstract: A strip diverting mechanism includes a negative pressure unit and an air discharge unit. The negative pressure unit and the air discharge unit are arranged opposite each other, and a gap through which a strip passes is formed between the negative pressure unit and the air discharge unit. The negative pressure unit is configured to provide a suction force to the strip and the air discharge unit is configured to provide a repulsive force to the strip, to prevent the strip from contacting the negative pressure unit and the air discharge unit.

Abstract: An optical fiber sensing system for temperature and salinity synchronous measurement is provided, which includes a broad-spectrum light source, an optical fiber circulator, a coupler, a first interferometer, a second interferometer, a third interferometer and a spectrometer; the first interferometer is insensitive to temperature and salinity; the second interferometer is sensitive to both temperature and salinity, and the third interferometer is only sensitive to temperature; light emitted by the broad-spectrum light source passes through the optical fiber circulator and enters the first interferometer; reflected light of the first interferometer passes through the optical fiber circulator and the coupler sequentially, and then enters the second and the third interferometers respectively; the reflected light of the second and the third interferometers enters the spectrometer after passing through the coupler; the temperature and the salinity to be measured are simultaneously obtained by performing spectral an

Abstract: The present embodiments relate to a time-sensitive network control system and a centralized network configuration entity for controlling data traffic in the time-sensitive network control system.

Abstract: A strip diverting mechanism includes a negative pressure unit and an air discharge unit. The negative pressure unit and the air discharge unit are arranged opposite each other, and a gap through which a strip passes is formed between the negative pressure unit and the air discharge unit. The negative pressure unit is configured to provide a suction force to the strip and the air discharge unit is configured to provide a repulsive force to the strip, to prevent the strip from contacting the negative pressure unit and the air discharge unit.

Abstract: Multi-stage polymeric particles are prepared as a water-borne emulsion, including a first-formed lower Tg soft stage and a second-formed higher Tg hard stage. The polymeric particles include, in both stages: one or more free radical polymerizable ethylenically unsaturated monomers; 0 to 3 wt % of free radical polymerizable surfactant monomer; 0 to 4 wt % of free radical poly-merizable monomer having a beta dicarbonyl functionality; 0 to 2 wt % of monomer selected from acrylamide, diacetone acrylamide, 2-hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylates, and hydroxybutyl (meth)acrylates and mixtures thereof; 0-1.9 wt % of free radical polymerizable polyethylenically unsaturated monomers; 0.1 to 1.9% of free radical polymerizable monomer containing phosphorus acid or a salt thereof in the first stage, and 0.1 to 5 wt % of a free radical polymerizable monomer containing phosphorus acid or salt thereof in the second stage.

Abstract: A drying apparatus and an oven are provided. In some embodiments, the drying apparatus is used for drying a material. The drying apparatus includes: a blowing mechanism having an air-outlet channel for conveying dry gas to the material; and a guide member movably arranged in the air-outlet channel and used for dividing the air-outlet channel into a first sub-air-outlet channel and a second sub-air-outlet channel, and a first air outlet of the first sub-air-outlet channel and a second air outlet of the second sub-air-outlet channel both facing the material. In the above way, the drying apparatus provided in the present application is capable of realizing adjustment of an air speed without changing an air volume, thereby ensuring the drying efficiency.

Abstract: The present application discloses a drying device and an electrode plate manufacturing apparatus. The drying device for drying a material comprises: a first oven section; a second oven section; and a third oven section, the first oven section, the second oven section and the third oven section being arranged sequentially in a movement direction of the material, wherein the second oven section has a larger air outlet area than the first oven section, and the first oven section has a larger air outlet area than the third oven section, such that the air speed of the first oven section is greater than that of the second oven section, and the air speed of the third oven section is greater than that of the first oven section. The solution provided by the present application can increase the production efficiency of batteries.

Abstract: A laser scanning device (10), comprising: a system on chip structure (110) configured to receive and process a graphic data transmitted by an external computer (20) to generate a galvanometer movement instruction and a laser control instruction; and galvanometer (120) configured to receive the galvanometer movement instruction and move according to the galvanometer movement instruction; wherein the laser control instruction is transmitted to an external laser (30), so that the laser (30) and the galvanometer (120) move synchronously. The above laser scanning device (10) and scanning system can integrate a laser control function and a galvanometer control function into the same chip by a system on chip design, which does not only reduce cost of the system, but also improve reliability of the system.

Abstract: Catalysts for producing one or more oxygenated products from methane are provided. In embodiments, the catalyst comprises active sites comprising isolated, cationic transition metal M? atoms covalently bound to internal surfaces of pores of a porous metal M? silicate, wherein M? is Rh or Ir, and further wherein the M? atoms are bound to five oxygen (O) atoms. Methods for making and using the catalysts are also provided.

Abstract: Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.

Abstract: The present disclosure provides a Redis Key management method, for managing and controlling Redis Keys generated by a same task in a streaming framework, the Redis Key management method including: packaging the Redis Keys generated by the same task and storing packaged Redis Keys in a same Key bucket; performing a duplicate-removal processing on Redis Keys in the same Key bucket for being called by external data; and performing a batch deletion on Redis Keys after being called by external data. In the present disclosure, Redis Keys in the same task and located in the same partition may be stored in a Key bucket. Key buckets may be located. Duplicate-removal processing may be performed on the Redis Keys in the same Key bucket so that the Redis Keys can be called by external data. A batch deletion may be performed on the Redis Keys after being called by external data.

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.