Patents by Inventor YU XIANG LI

YU XIANG LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11972583
    Abstract: The present disclosure provides a fluorescence image registration method, the method includes: acquiring a fluorescence image of a biochip; selecting a preset local region of the fluorescence image; acquiring a position of a minimum value of a sum of brightness values of pixels in a first direction and a second direction, and obtaining pixel-level registration points; dividing the pixel-level registration points into non-defective pixels and defective pixels; if the fluorescence image meets the preset standard, correcting positions of the defective pixels according to positions of the non-defective pixels; acquiring a position of a center of gravity of image points of fluorescent molecules according to a center of gravity method; fitting straight lines in the first direction and the second direction respectively according to the position of the center of gravity; and acquiring boundary points of the fluorescence image and calculating the positions of the boundary points.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 30, 2024
    Assignee: BGI SHENZHEN
    Inventors: Jin-Jin Shen, Da-Wei Li, Yang-Bao Liu, Ge Feng, Mei Li, Yu-Xiang Li
  • Publication number: 20230298188
    Abstract: A fluorescence image registration method includes obtaining at least one fluorescence image of a biochip. An interior local area is selected. Sums of pixel values in the interior local area along a first direction and a second direction are obtained. A plurality of first template lines is selected to find a minimum total value of the sums of pixel values corresponding to the first template lines. Pixel-level correction is performed on a local area of the track line to obtain pixel-level track cross. Other track crosses on the biochip is obtained, and the pixel-level correction is performed on the other track crosses. The position of the pixel-level track line is corrected by a center-of-gravity method to obtain the subpixel-level position of the track line. The subpixel-level positions of all sites uniformly distributed on the biochip is obtained.
    Type: Application
    Filed: May 24, 2023
    Publication date: September 21, 2023
    Inventors: MEI LI, YU-XIANG LI, YI-WEN LIU
  • Patent number: 11682125
    Abstract: A fluorescence image registration method includes obtaining at least one fluorescence image of a biochip. An interior local area. Sums of pixel values in the interior local area along a first direction and a second direction are obtained. A plurality of first template lines is selected to find a minimum total value of the sums of pixel values corresponding to the first template lines. Pixel-level correction is performed on a local area of the track line to obtain a pixel-level track cross. Other track crosses on the biochip is obtained, and the pixel-level correction is performed on the other track crosses. The position of the pixel-level track line is corrected by a center-of-gravity method to obtain the subpixel-level position of the track line. The subpixel-level positions of all sites uniformly distributed on the biochip is obtained.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: June 20, 2023
    Assignee: MGI Tech Co., Ltd.
    Inventors: Mei Li, Yu-Xiang Li, Yi-Wen Liu
  • Publication number: 20220108462
    Abstract: The present disclosure provides a fluorescence image registration method, the method includes: acquiring a fluorescence image of a biochip; selecting a preset local region of the fluorescence image; acquiring a position of a minimum value of a sum of brightness values of pixels in a first direction and a second direction, and obtaining pixel-level registration points; dividing the pixel-level registration points into non-defective pixels and defective pixels; if the fluorescence image meets the preset standard, correcting positions of the defective pixels according to positions of the non-defective pixels; acquiring a position of a center of gravity of image points of fluorescent molecules according to a center of gravity method; fitting straight lines in the first direction and the second direction respectively according to the position of the center of gravity; and acquiring boundary points of the fluorescence image and calculating the positions of the boundary points.
    Type: Application
    Filed: January 31, 2019
    Publication date: April 7, 2022
    Inventors: JIN-JIN SHEN, DA-WEI LI, YANG-BAO LIU, GE FENG, MEI LI, YU-XIANG LI
  • Publication number: 20220091112
    Abstract: A microbead with a code engraved on an outside of the microbead. The microbead includes a central region and an edge region surrounding the central region. An outer contour of the edge region before and after engraving the code is non-circular. The edge region includes a plurality of coding positions. The code of the microbead is engraved on the plurality of coding positions. Each bit of the code corresponds to each of the plurality of coding positions. The present disclosure increases the utilization rate of the microbead.
    Type: Application
    Filed: January 23, 2019
    Publication date: March 24, 2022
    Inventors: WEN-WEI ZHANG, WEI CHEN, WEI-MAO WANG, MEI LI, YU-XIANG LI, JIAN WANG
  • Publication number: 20210019895
    Abstract: A fluorescence image registration method includes obtaining at least one fluorescence image of a biochip. An interior local area. Sums of pixel values in the interior local area along a first direction and a second direction are obtained. A plurality of first template lines is selected to find a minimum total value of the sums of pixel values corresponding to the first template lines. Pixel-level correction is performed on a local area of the track line to obtain a pixel-level track cross. Other track crosses on the biochip is obtained, and the pixel-level correction is performed on the other track crosses. The position of the pixel-level track line is corrected by a center-of-gravity method to obtain the subpixel-level position of the track line. The subpixel-level positions of all sites uniformly distributed on the biochip is obtained.
    Type: Application
    Filed: April 10, 2018
    Publication date: January 21, 2021
    Inventors: MEI LI, YU-XIANG LI, YI-WEN LIU
  • Patent number: 10091627
    Abstract: Message handshaking and integration may be provided. A message may be created by a client in a first format. The client may determine whether a server in communication with the client is operable to deliver the message in a second format. If so, the client may provide the message, in the first format, to the server for delivering to at least one recipient in the second format.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: October 2, 2018
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Yong Gang Mao, Shang Tao Zhou, Dong Dong Guo, Gleb Kholodov, Giok Hong Khoo, Yu Xiang Li, Ning Wang, Dong Hui Zhang, Yi Zhang
  • Publication number: 20110238732
    Abstract: Message handshaking and integration may be provided. A message may be created by a client in a first format. The client may determine whether a server in communication with the client is operable to deliver the message in a second format. If so, the client may provide the message, in the first format, to the server for delivering to at least one recipient in the second format.
    Type: Application
    Filed: March 23, 2010
    Publication date: September 29, 2011
    Applicant: MICROSOFT CORPORATION
    Inventors: YONG GANG MAO, SHANG TAO ZHOU, DONG DONG GUO, GLEB KHOLODOV, GIOK HONG KHOO, YU XIANG LI, NING WANG, DONG HUI ZHANG, YI ZHANG