Abstract: Disclosed is a method for determining the dynamic adsorption retention of polymer capsules, belonging to the technical field of oil and gas field development engineering, which includes: (1) carrying out a thermal aging experiment to establish relational expressions between a capsule concentration and an aging time, as well as a polymer release concentration and the aging time; (2) setting up a polymer capsule displacement experimental device to determine the release concentration of polymers in effluent; (3) releasing polymers encapsulated by capsules in the effluent to acquire a total adsorption retention of polymers in a porous medium; and (4) inverting respective adsorption retentions of the capsule particles and the polymers in the porous medium.

Abstract: Disclosed in the present invention is a cable dome structure using continuous ridge cables. A structure system includes n same plane trusses which are distributed in the radial direction and each consist of continuous cables and rods, the plane trusses being connected by means of k?1 circles of hoop cables to form a stable whole. The cable dome structure consists of ridge cables, hoop cables and pressing rods. Each ridge cable starts from a lower joint of a pressing rod and sequentially passes through upper joints of outer side pressing rods, and all the ridge cables converge on a support joint. The ridge cables have overlaps. Upper joints of the pressing rods and inner side adjacent cables are fixedly connected, and lower joints of the pressing rods and the hoop cables are fixedly connected, the cables slidably passing through the joints.

Abstract: A method for intelligently distributing messages across multiple devices and associated chat applications is disclosed. In one embodiment, such a method includes registering multiple devices and associated chat applications to receive intelligent distribution of messages. The method monitors, using an agent, a message copied from a first device of the multiple devices to a clipboard. The method automatically analyzes content of the message to determine which other devices and associated chat applications of the plurality are eligible to receive the message. The message is then distributed to other devices and associated chat applications that are deemed eligible to receive the message. In certain embodiments, the message originates from a first chat application of a first type and the message is distributed to a second chat application of a second type that is different from the first type. A corresponding system and computer program product are also disclosed.

Abstract: Computer-implemented methods for performing shutdown of a computing system using custom shutdown intervals are provided. Aspects include receiving, by the computing system, a command to shutdown the computing system and issuing a first command to shutdown a first subsystem of the computing system. Aspects also include determining, after a first interval since issuing the first command, that the first subsystem has not shutdown and issuing a second command to shutdown the first subsystem of the computing system, wherein the first interval is obtained from a trained machine learning model.

Abstract: Shutdown intervals between nodes of a dependency tree are determined. The dependency tree represents a system to be shut down and the nodes represent system components of the system. The determining the shutdown intervals includes calculating, for a pair of nodes of the dependency tree, a shutdown interval. The calculating is based on a relationship between the pair of nodes. The calculating is repeated for a plurality of pairs of nodes to obtain a plurality of shutdown intervals. The plurality of shutdown intervals is used in a shutdown of the system components. At least one system component represented by at least one node on a higher node level of the dependency tree is to be shut down prior to at least one other system component represented by at least one other node on a lower node level of the dependency tree.

Abstract: A method, computer system, and a computer program product are provided for managing an accelerated shutdown of a networked system having a having a plurality of nodes. The system to be shutdown is analyzed and a priority order is determined for the nodes. An interval period is also determined between each node according to the priority order. A leaf node set is constructed according to different shutdown types required for each node and a dependency tree is constructed by analyzing the leaf node sets. Each node is then shutdown according to the tree and the interval period determined. The dependency tree and the interval period is iteratively modified during the node shutdown until all nodes and ultimately the system shutdown has been completed.

Abstract: Disclosed in the present invention is a cable dome structure using continuous ridge cables. A structure system includes n same plane trusses which are distributed in the radial direction and each consist of continuous cables and rods, the plane trusses being connected by means of k?1 circles of hoop cables to form a stable whole. The cable dome structure consists of ridge cables, hoop cables and pressing rods. Each ridge cable starts from a lower joint of a pressing rod and sequentially passes through upper joints of outer side pressing rods, and all the ridge cables converge on a support joint. The ridge cables have overlaps. Upper joints of the pressing rods and inner side adjacent cables are fixedly connected, and lower joints of the pressing rods and the hoop cables are fixedly connected, the cables slidably passing through the joints.

Abstract: A system and/or method that can reduce impact of network latency can be provided. Information associated with a user device participating in an online meeting can be determined, for user devices connecting to the online meeting. Based on the information, the user devices can be grouped. For each of the user devices in a group, network quality associated with network connection between a user device in the group and a server managing the online meeting can be evaluated. Based on the network quality, at least one user device in the group can be designated to operate as a sharer device to at least one other user device in the group. The sharer device can be caused to stream data directly from the server during the online meeting. That one other user device can be caused to connect with and stream data from the sharer device.

Abstract: An acoustic monitoring system and method for the health status of an offshore wind turbine and an ocean wave are provided. The acoustic monitoring system includes a first laser transmitter, a second laser transmitter, a telephoto camera provided at a hub, a vibration detection sensor provided on a tower of a wind turbine, and four acoustic detection sensors arranged at an interval of 90° along the circumference of the tower. The first and second laser transmitters are arranged at the bottom of a nacelle of the wind turbine and emit laser lights vertically downward. The first laser transmitter, the second laser transmitter, the telephoto camera, the vibration detection sensor, and the acoustic detection sensors are connected to a data acquisition and conversion module through a transmission module. The acoustic monitoring system combines laser light detection with acoustic signal feature detection to improve stability and safety of the offshore wind turbine.

Abstract: An acoustic monitoring system and method for the health status of an offshore wind turbine and an ocean wave are provided. The acoustic monitoring system includes a first laser transmitter, a second laser transmitter, a telephoto camera provided at a hub, a vibration detection sensor provided on a tower of a wind turbine, and four acoustic detection sensors arranged at an interval of 90° along the circumference of the tower. The first and second laser transmitters are arranged at the bottom of a nacelle of the wind turbine and emit laser lights vertically downward. The first laser transmitter, the second laser transmitter, the telephoto camera, the vibration detection sensor, and the acoustic detection sensors are connected to a data acquisition and conversion module through a transmission module. The acoustic monitoring system combines laser light detection with acoustic signal feature detection to improve stability and safety of the offshore wind turbine.

Abstract: The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.

Abstract: A method for a device to monitor performance of a manufacturing machine which is equipped with a fixture for holding a workpiece, the fixture having at least one fixing hole, includes obtaining actual coordinate values of the fixing hole in a plurality of machining processes and calculating a standard deviation of the coordinates in at least one axial direction according to the actual coordinate values and a preset standard coordinate value. A risk index in at least one axial direction is calculated according to the standard deviation and a preset tolerance and a determination made as to whether risk index exceeds a preset threshold. A warning is sent to the machine and supervising engineer if the risk exceeds the preset threshold. A machine monitoring device and a computer readable storage medium are also provided.

Abstract: A method for a device to monitor performance of a manufacturing machine which is equipped with a fixture for holding a workpiece, the fixture having at least one fixing hole, includes obtaining actual coordinate values of the fixing hole in a plurality of machining processes and calculating a standard deviation of the coordinates in at least one axial direction according to the actual coordinate values and a preset standard coordinate value. A risk index in at least one axial direction is calculated according to the standard deviation and a preset tolerance and a determination made as to whether risk index exceeds a preset threshold. A warning is sent to the machine and supervising engineer if the risk exceeds the preset threshold. A machine monitoring device and a computer readable storage medium are also provided.

Abstract: The present disclosure relates to a Pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, preparation method thereof and use thereof. The compounds of the present invention have good inhibitory activities against BTK at the molecular and cellular levels. Importantly, the compounds of the present invention have low activity against Ramos cells of normal human B lymphoma cells, and have high activity against BTK-sensitive human diffuse large B lymphoma TMD8 cells, indicating that these type of compounds with novel structural are highly selective, off-target phenomenon and corresponding side effects are low. Thus it is a selective inhibitor of BTK with development potential.

Abstract: The present disclosure relates to a Pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, preparation method thereof and use thereof. The compounds of the present invention have good inhibitory activities against BTK at the molecular and cellular levels. Importantly, the compounds of the present invention have low activity against Ramos cells of normal human B lymphoma cells, and have high activity against BTK-sensitive human diffuse large B lymphoma TMD8 cells, indicating that these type of compounds with novel structural are highly selective, off-target phenomenon and corresponding side effects are low. Thus it is a selective inhibitor of BTK with development potential.

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract: Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.