Abstract: Provided is a method for realizing the controlled release and sustained release of the activity of bioactive molecules and use for drugs. Provided is a PEG modifier of a specific structure. The PEG modifier can be widely applied to the controlled release and sustained release of the activity of various bioactive molecules. A conjugate is formed by reacting the PEG modifier of the specific type and structure with IL-2. In a certain in vitro condition or in vivo physiological condition, PEG gradually falls off from the conjugate and the activity of IL-2 is gradually released, so that a certain effective plasma concentration where bioactive molecules are relatively stable can be maintained, and thus the in vivo or in vitro sustained release and controlled release of the activity of the drug are realized.

Abstract: The embodiments of the present disclosure provide a resource processing method, a resource scheduling method, a computing device and a computer storage medium, where the resource processing method includes: creating, according to the number of a pod needed by a target application, at least one instance corresponding to the number of the pod for the target application; performing, according to a resource requirement parameter of the at least one instance and respective available resources of multiple nodes respectively, simulation scheduling in the multiple nodes to determine at least one target node and a respective reserved resource thereof; and generating, according to a simulation scheduling result, a resource reservation result of the target application, where the resource reservation result is used to instruct to perform resource scheduling for the target application by using the a reserved resource of the at least one target node.

Abstract: Provided is use of kinin or derivative thereof, in particular long-acting kinin or derivative thereof, in treating vascular cognitive impairment (VCI), post-stroke cognitive impairment (PSCI), or cerebral small vessel disease (CSVD). VCI and PSCI are generally associated with cognitive function impairment and psychoactive behavioral symptom. Drugs for treating cognitive impairment in VCI and PSCI include cholinesterase inhibitors, non-competitive N-methyl-D-asparagine receptor antagonists, and drugs for treating psychoactive behavioral symptom include antidepressants. Patients with chronic CSVD may have symptoms such as cognitive disorder, movement disorder, emotional disorder, defecation disorder and other symptoms. Cholinesterase inhibitors and non-competitive N-methyl-D-asparagine receptor antagonists can be used for cognitive disorder, and antidepressants are generally used for depression.

Abstract: A recombinant type I allergen of Artemisia annua pollen (Art a 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art a 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art a 1 is equivalent to that of a native protein, and the Art a 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

Abstract: A recombinant type I allergen of Artemisia vulgaris pollen (Art v 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art v 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art v 1 is equivalent to that of a native protein, and the Art v 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

Abstract: Provided are low glycosylated kallikrein I with no or a small amount of glycosylation at the NFS sequence and polyethylene glycol modified product and pharmaceutical applications. KLK1 with lower glycosylation at NFS is more active than KLK1 with higher glycosylation at NFS. A recombinant KLK1 mutant without N-glycosylation at the NFS sequence is also provided, containing only two N-glycosylation sites at NMS and NHT. Glycosylation of the recombinant KLK1 mutant is relatively more consistent, the molecular weight of the product is relatively more homogeneous, the yield is higher, the purification process is simpler, and the biological activity is higher, and the quality is more controllable.

Abstract: Top-mount PCB mounting assemblies, and electronic devices and optical communication device thereof are provided. The top-mount PCB mounting assemblies may include a PCB with a top surface as a reference surface; a chassis disposed underneath the PCB and separate from the PCB; a shoulder screw comprising a screw head, a screw body and a screw tail, where the shoulder screw is soldered on a top of the PCB and is connected to the chassis by tightening a M2.5 screw from a bottom of the chassis; and a nut, positioned between the PCB and the chassis, made of a rigid feature, and configured to receive and fasten the shoulder screw and keep a distance between the PCB and the chassis within a controlled dimension.

Abstract: An approach is provided in which a set of provision information is generated from a set of provisioners that are in process of fulfilling a client's provision request. The approach creates a set of provision events based on the set of provision information and, in response to detecting a failure of the provision request, the approach generates a provision chain from the set of provision events. The provision chain links the set of provision events based on correlation rules and identifies at least one isolation point of the failure. The approach informs the client of the at least one isolation point of the failure identified in the provision chain.

Abstract: An approach is provided in which a set of provision information is generated from a set of provisioners that are in process of fulfilling a client's provision request. The approach creates a set of provision events based on the set of provision information and, in response to detecting a failure of the provision request, the approach generates a provision chain from the set of provision events. The provision chain links the set of provision events based on correlation rules and identifies at least one isolation point of the failure. The approach informs the client of the at least one isolation point of the failure identified in the provision chain.

Abstract: Embodiments of the present disclosure relate to a computer-implemented method for executing one or more operations based on a command. According to the method, a command is received. A command name of the command and one or more parameters of the command are extracted. A command description file corresponding to the command is retrieved based on the command name. The command description file describes function logic of the command. The retrieved command description file is parsed, and information for executing one or more operations included in the command description file is acquired. The one or more operations are executed based on the acquired information and the one or more parameters.

Abstract: Embodiments of the present disclosure relate to a computer-implemented method for executing a command. According to the method, a command is received. A command name of the command and one or more parameters of the command are extracted. A command description file corresponding to the command is retrieved based on the command name. The command description file describes function logic of the command. Information for executing one or more operations included in the command description file is acquired by parsing the retrieved command description file. The one or more operations are executed based on the acquired information and the one or more parameters.

Abstract: A data storage system stores historical statistical data in a statistics hierarchy that is a tree of nodes. The data storage system receives a metric request from a remote requesting device through a Representational State Transfer (RESTful) Application Programming Interface (API), including a metric path that is a delimited list of list elements separated by delimiter characters. In response to an aggregation special character in the metric path, the data storage system i) obtains a category name immediately preceding the aggregation special character in the metric path, ii) identifies a branch of the statistics hierarchy indicated by the category name, iii) aggregates values of leaf nodes contained in the branch of the statistics hierarchy indicated by the category name that match a leaf type in the metric path to generate an aggregated value, and iv) transmits a metric response containing the aggregated value to the remote requesting device.

Abstract: Methods, systems, and apparatus for optical communications. One of the apparatuses includes a spool comprising a spool wheel, one or more separate spool portions positioned on the spool wheel, and one or more bearings positioned on the spool wheel, wherein the one or more spool portions and the one or more bearings are configured such that an optical fiber ribbon can be wound through the spool; and a spring coupled to the spool wheel such that the spring provides a rotational force on the spool in a direction that winds the optical fiber ribbon.

Abstract: Embodiments relate to preview serving of content previews from a preview service for a component having associated content. A filter of a layered preview service executing on a processor receives a request from a client consumer for a feed from the component. The filter identifies a content reference returned by the component in response to the request for the feed. The filter establishes an association between the content reference and a user identifier of the client consumer as an authorization record. A preview service receives a preview request including the user identifier and a content identifier. The authorization record is checked to determine whether the content identifier matches the content reference for the user identifier. A content preview of the associated content as identified by the content identifier is served based on determining that a match exists.

Abstract: A cable connector assembly including: a cable including a number of core wires, each core wire including an insulative layer and an inner conductor; and an electrical connector connected with an end of the cable, the electrical connector including an insulative housing, a number of contacts retained in the insulative housing, a shell member enclosing the insulative housing, a cover member assembled on a rear end of the insulative housing for fixing the core wires, and a carrying member connected between the cover member and the insulative housing, each of the contacts including a mounting portion rearwardly exposed to the insulative housing, wherein each of the mounting portion defines a spines portion, the cover member defines a number of through holes receiving the core wires, and the insulative layer of the core wire is punctured by the spines portion when the cover member is mounted on the carrying member.

Abstract: A cable connector assembly including: a cable including a number of core wires, each core wire including an insulative layer and an inner conductor; and an electrical connector connected with an end of the cable, the electrical connector including an insulative housing, a number of contacts retained in the insulative housing, a shell member enclosing the insulative housing, a cover member assembled on a rear end of the insulative housing for fixing the core wires, and a carrying member connected between the cover member and the insulative housing, each of the contacts including a mounting portion rearwardly exposed to the insulative housing, wherein each of the mounting portion defines a spines portion, the cover member defines a number of through holes receiving the core wires, and the insulative layer of the core wire is punctured by the spines portion when the cover member is mounted on the carrying member.

Abstract: Embodiments relate to preview serving of content previews from a preview service for a component having associated content. A filter of a layered preview service executing on a processor receives a request from a client consumer for a feed from the component. The filter identifies a content reference returned by the component in response to the request for the feed. The filter establishes an association between the content reference and a user identifier of the client consumer as an authorization record. A preview service receives a preview request including the user identifier and a content identifier. The authorization record is checked to determine whether the content identifier matches the content reference for the user identifier. A content preview of the associated content as identified by the content identifier is served based on determining that a match exists.

Abstract: Methods, systems, and apparatus for optical communications. One of the apparatuses includes a spool comprising a spool wheel, one or more separate spool portions positioned on the spool wheel, and one or more bearings positioned on the spool wheel, wherein the one or more spool portions and the one or more bearings are configured such that an optical fiber ribbon can be wound through the spool; and a spring coupled to the spool wheel such that the spring provides a rotational force on the spool in a direction that winds the optical fiber ribbon.

Abstract: A power amplifier with noise shaping function is provided. The power amplifier includes a differential mode integrator, an integration and adjustment unit and a switch unit. The differential mode integrator is used for receiving a differential mode input signal and a differential mode output signal, and outputting a differential mode first signal. The integration and adjustment unit is coupled to the differential mode integrator for receiving the first signal and an output signal and outputting a single-end mode second signal. The switch unit is used for receiving the second signal and outputting the differential mode output signal to drive the load. The present invention uses a common mode input signal instead of the single-end input signal to eliminate the common mode noise, and uses a 2nd-order (or more than that) integrating circuit instead of the conventional filter to achieve a preferred effect of reducing the off band noise.

Abstract: A power amplifier with noise shaping function is provided. The power amplifier includes a differential mode integrator, an integration and adjustment unit and a switch unit. The differential mode integrator is used for receiving a differential mode input signal and a differential mode output signal, and outputting a differential mode first signal. The integration and adjustment unit is coupled to the differential mode integrator for receiving the first signal and an output signal and outputting a single-end mode second signal. The switch unit is used for receiving the second signal and outputting the differential mode output signal to drive the load. The present invention uses a common mode input signal instead of the single-end input signal to eliminate the common mode noise, and uses a 2nd-order (or more than that) integrating circuit instead of the conventional filter to achieve a preferred effect of reducing the off band noise.