Abstract: A method for preparing a composite matrix containing chitosan derivatives, comprising the steps of: (a) providing an anionic chitosan derivative solution (A); (b) providing a cationic polysaccharide solution (B); and (c) mixing solution (A) and solution (B) to form microcapsules. Metallic ion cross-linking agent and/or natural protein solution can be added optionally to adjust the mechanical strength of the shell and the interior physic state of the microcapsules.

Abstract: The present invention relates to a biodegradable thermal-sensitive gel system, which comprises at least one polysaccharide solution, at least one electrolytic salt, and at least one buffer solution for adjusting pH. A natural protein as well as a cross-linking agent can be added to the gel system optionally. Said gel system is liquid at room temperature (25° C.) and solidifies at or above 37° C.

Abstract: A biodegradable composite matrix for enhancing angiogenesis. The matrix includes a biodegradable material and a phospholipid distributed in the biodegradable material as a liposome or micelle. Derivatives of phospholipid have chemo-attraction properties and thus induce the transfer of endothelial cells into the system through tropism-inductive mechanism. The biodegradable composite matrix induces an intracellular signal cascade that is different from cascade induced by a growth factor, and can coordinate with the growth factor-induced cascade to enhance angiogenesis. The present invention also includes the method for producing the biodegradable composite matrix.