Patents by Inventor Yuan Mi

Yuan Mi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppressant compounds and compositions
    Patent number: 7718704
    Abstract: The invention provides a novel class of cyclic oximes of Formula I: wherein A, X, Y, Z, W, R1, R2, R3 and n are as described in the summary of the invention; useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: May 18, 2010
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Wenqi Gao, Nathanael Schiander Gray, Yuan Mi
  • PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF
    Publication number: 20100087464
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of TrkA, TrkB, TrkC, Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC?, Raf, ROCK-II, Rsk1, and SGK kinases, or a combination thereof.
    Type: Application
    Filed: August 27, 2007
    Publication date: April 8, 2010
    Applicant: IRM LLC
    Inventors: Yuan Mi, Pamela A. Albaugh
  • Immunosuppressant compounds and compositions
    Patent number: 7572811
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: August 11, 2009
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Wenqi Gao, Nathanael Schiander Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS
    Publication number: 20090131400
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: July 25, 2008
    Publication date: May 21, 2009
    Applicant: IRM LLC
    Inventors: Yuan Mi, Shifeng Pan, Nathanael Schiander Gray, Wenqi Gao, Yi Fan, Tao Jiang
  • IMMUNOSUPPRESANT COMPOUNDS AND COMPOSITIONS
    Publication number: 20090036423
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: February 1, 2008
    Publication date: February 5, 2009
    Inventors: Shifeng Pan, Wenqi Gao, Nathanael S. Gray, Yuan Mi, Yi Fan
  • Immunosuppressant compounds and compositions
    Patent number: 7462629
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: December 9, 2008
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Nathanael S. Gray, Yuan Mi, Yi Fan, Wenqi Gao
  • Compounds and Compositions as Protein Kinase Inhibitors
    Publication number: 20080221192
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
    Type: Application
    Filed: November 7, 2005
    Publication date: September 11, 2008
    Applicant: IRM LLC
    Inventors: Yongqin Wan, Yuan Mi, Yi Fan, Dai Cheng, Yi Liu, Nathanael S. Gray, Pamela Albaugh
  • Immunosuppressant compounds and compositions
    Patent number: 7417065
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: August 26, 2008
    Assignee: IRM LLC
    Inventors: Yuan Mi, Shifeng Pan, Nathanael Schiander Gray, Wenqi Gao, Yi Fan, Tao Jiang
  • Immunosuppressant Compounds and Compositions
    Publication number: 20070203100
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: February 24, 2005
    Publication date: August 30, 2007
    Applicant: IRM LLC
    Inventors: Shifeng Pan, Thomas Marsilje, Wenshuo Lu, Gao Wenqi, Nathanael Gray, Yun He, Yahua Liu, Yuan Mi, Yongping Xie
  • Bicyclic compounds and compositions
    Patent number: 7256206
    Abstract: The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: August 14, 2007
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Nathanael S. Gray, Yuan Mi, Wenqi Gao, Yi Fan, Sophie Lefebvre
  • Immunosuppressant compounds and compositions
    Publication number: 20070167410
    Abstract: The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: February 24, 2005
    Publication date: July 19, 2007
    Applicant: IRM LLC
    Inventors: Shifeng Pan, Wenqi Gao, Nathanael Gray, Yuan Mi
  • Bis-aromatic alkanols
    Patent number: 7169817
    Abstract: The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: wherein the substituents have the values mentioned herein.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: January 30, 2007
    Assignee: IRM LLC
    Inventors: Shifeng Pan, Nathanael S. Gray, Wenqui Gao, Klaus Hinterding, Sophie Lefebvre, Yuan Mi, Peter Nussbaumer, Wei Wang, Federic Zecri, Fan Yi, Lawrence Blas Perez, Kenneth Richad la Montagne, Peter Ettmayer
  • Immunosuppressant compounds and compositions
    Publication number: 20050014725
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 20, 2005
    Applicant: IRM LLC
    Inventors: Yuan Mi, Shifeng Pan, Nathanael Gray, Wenqi Gao, Yi Fan, Tao Jiang
  • Immunosuppressant compounds and compositions
    Publication number: 20050014728
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 20, 2005
    Inventors: Shifeng Pan, Wenqi Gao, Nathanael Gray, Yuan Mi, Yi Fan
  • Immunosuppressant compounds and compositions
    Publication number: 20050009786
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 13, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Shifeng Pan, Nathanael Gray, Yuan Mi, Yi Fan, Wengi Gao
  • Novel bicyclic compounds and compositions
    Publication number: 20040248952
    Abstract: The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.
    Type: Application
    Filed: February 11, 2004
    Publication date: December 9, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Shifeng Pan, Nathanael S. Gray, Yuan Mi, Wenqi Gao, Yi Fan, Sophie Lefebvre
  • Bis-aromatic alkanols
    Publication number: 20040048857
    Abstract: The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 27, 2003
    Publication date: March 11, 2004
    Applicants: IRM LLC, Novartis AG
    Inventors: Shifeng Pan, Nathanael S. Gray, Wenqi Gao, Klaus Hinterding, Sophie Lefebvre, Yuan Mi, Peter Nussbaumer, Wei Wang, Federic Zecri, Fan Yi, Lawrence Blas Perez, Kenneth Richard la Montagne, Peter Ettmayer