Abstract: The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Abstract: Systems and methods for training a neural network or an ensemble of neural networks are described. A hyper-parameter that controls the variance of the ensemble predictors is used to address overfitting. For larger values of the hyper-parameter, the predictions from the ensemble have more variance, so there is less overfitting. This technique can be applied to ensemble learning with various cost functions, structures and parameter sharing. A cost function is provided and a set of techniques for learning are described.

Abstract: A method for repairing a white defect of a LCD panel includes providing a substrate, the substrate defining pixel areas which themselves comprise a base, a first metal layer, a first insulating layer, a semi-conductor layer, an ohmic contact layer, a source electrode, a drain electrode, and a second insulating layer; forming a through hole by laser in the second insulating layer, the through hole extending through the second insulating layer and separating the drain electrode into two spaced parts; forming a third insulating layer to cover the first conductive layers, the second insulating layer and the though hole and forming a second conductive layer by laser on the third insulating layer to couple the first conductive layer to the second conductive layer.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: We describe systems and methods for generating and training convolutional neural networks using biological sequences and relevance scores derived from structural, biochemical, population and evolutionary data. The convolutional neural networks take as input biological sequences and additional information and output molecular phenotypes. Biological sequences may include DNA, RNA and protein sequences. Molecular phenotypes may include protein-DNA interactions, protein-RNA interactions, protein-protein interactions, splicing patterns, polyadenylation patterns, and microRNA-RNA interactions, which may be described using numerical, categorical or ordinal attributes. Intermediate layers of the convolutional neural networks are weighted using relevance score sequences, for example, conservation tracks.

Abstract: A manufacture method of a black matrix is provided. The COA technology is utilized to manufacture organic photoresist blocks with an increased thickness on alignment marks. Then, a black matrix thin film is set on and covers the organic photoresist blocks to tremendously increase the level differences of the positions of the alignment marks and adjacent areas. A contour recognition apparatus can accurately recognize positions of the alignment marks. The issue that the alignment marks are difficult to recognize after the black matrix thin film is coated in the BOA process can be solved.

Abstract: A measuring method and a liquid crystal display panel are provided. The measuring method includes disposing a test electrode on an outside of the liquid crystal display panel, and electrically connecting the test electrode with a pixel electrode, and measuring a voltage of the pixel electrode by the test electrode when the liquid crystal display panel is in operation. The voltage of the pixel electrode can be directly measured by the measuring method, thereby increasing the accuracy for measuring the driving voltage of liquid crystal.

Abstract: The present invention provides a method and a device for releasing film layer stress of an array substrate.

Abstract: The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Abstract: A manufacturing method of a display device comprises steps: a lining layer is formed on an array substrate; a conduction layer is formed on the array substrate, wherein the conduction layer partially covers a surface of said lining layer, wherein said conduction layer refers to a second metal layer, a surface of said array substrate is also provided with a first metal layer connected with a common electrode of said array substrate and an indium tin oxide layer connected with said first metal layer, and said second metal layer is indirectly connected with said common electrode through connecting with said indium tin oxide layer; and a color filter substrate is enabled to abut pat of the conduction layer covering the surface of said lining layer, so that said conduction layer being conductive with said array substrate and said color filter substrate.

Abstract: Methods and systems for expanding a training set of one or more original biological sequences are provided. An original training set is obtained, wherein the original training set comprises one or more original biological sequences. Saliency values corresponding to one or more elements in each of the one or more original biological sequences are obtained. For each of the original biological sequences, one or more modified biological sequences are produced and the one or more modified biological sequences are associated with the original biological sequence. One or more elements are generated in each of the one or more modified biological sequences using one or more elements in the associated original biological sequence and the corresponding saliency values. The one or more modified biological sequences for each of the original biological sequences are added to the original training set to form an expanded training set.

Abstract: A pixel unit, a COA substrate and a liquid crystal display panel having the same are provided. In the pixel unit, a plurality of bridging holes share a color resist opening and a spacing between two adjacent bridging holes is less than a sum of conventional spacings separately corresponding to the two adjacent bridging holes. With the pixel unit, the space occupied by the color resist opening can be reduced, the space utilization of a TFT region is further improved, and the aperture opening ratio is increased.

Abstract: Described herein are systems and methods that receive as input a DNA or RNA sequence, extract features, and apply layers of processing units to compute one ore more condition-specific cell variables, corresponding to cellular quantities measured under different conditions. The system may be applied to a sequence containing a genetic variant, and also to a corresponding reference sequence to determine how much the condition-specific cell variables change because of the variant. The change in the condition-specific cell variables are used to compute a score for how deleterious a variant is, to classify a variant's level of deleteriousness, to prioritize variants for subsequent processing, and to compare a test variant to variants of known deleteriousness.

Abstract: The present invention provides a method and a device for releasing film layer stress of an array substrate.

Abstract: The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Abstract: A liquid crystal display panel includes an array substrate (1), a CF substrate (2) arranged to correspond to the array substrate (1), liquid crystal filled between the array substrate (1) and the CF substrate (2), enclosing resin (3) coated between the array substrate (1) and the CF substrate (2), and a photosensitive gap material barrier (4) arranged between the array substrate (1) and the CF substrate (2). The photosensitive gap material barrier (4) is arranged to circumferentially surround an outer periphery of a display zone (6) of the liquid crystal display panel. The photosensitive gap material barrier (4) has a height that is less than a distance between the array substrate (1) and the CF substrate (2). The photosensitive gap material barrier (4) includes a plurality of recessed cavities (41) formed therein.

Abstract: A COA (Color filter On Array) substrate and a manufacturing method using the same are disclosed. The method includes: forming a first metal layer, a gate insulation layer, a color resist layer, an active layer, a second metal layer, a passivation layer, a via hole, and a transparent conductive layer in order. The via hole is used for connecting to the transparent conductive layer with the second metal layer. The transparent conductive layer is formed on the passivation layer. A gate electrode is formed by pattering the first metal layer. A drain electrode and a source electrode are formed by pattering the second metal layer. In the present invention, the color resist layer is made before the second metal layer.

Abstract: A measuring method and a liquid crystal display panel are provided. The measuring method includes disposing a test electrode on an outside of the liquid crystal display panel, and electrically connecting the test electrode with a pixel electrode, and measuring a voltage of the pixel electrode by the test electrode when the liquid crystal display panel is in operation. The voltage of the pixel electrode can be directly measured by the measuring method, thereby increasing the accuracy for measuring the driving voltage of liquid crystal.