Patents by Inventor Yuan-Xiu Liao

Yuan-Xiu Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210078956
    Abstract: The present invention provides improved processes for the preparation of elagolix and intermediates thereof. The intermediate of formula VII is achieved by a coupling reaction of a compound of formula V and a N-benzylidene protected compound of formula IV: The present invention is suitable for a large-scale production, avoiding the use of potential genotoxic substances and can be performed under mild conditions.
    Type: Application
    Filed: September 17, 2020
    Publication date: March 18, 2021
    Inventors: Yung-Hung Chang, Tsung-Yu Hsiao, Yuan-Xiu Liao, Hsin-Chang Tseng
  • Patent number: 10919905
    Abstract: Crystalline form S1 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 8.7±0.2, 13.1±0.2, 14.5±0.2, 17.4±0.2, 18.4±0.2, 20.9±0.2, 24.0±0.2 and 27.5±0.2 degrees two-theta degrees two-theta, and crystalline form S2 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 7.1±0.2, 10.6±0.2, 12.4±0.2, 20.6±0.2, 21.6±0.2 and 24.2±0.2 degrees two-theta.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: February 16, 2021
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Yuan-Xiu Liao, Yuan-Chang Huang
  • Publication number: 20200361951
    Abstract: Crystalline form S1 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 8.7±0.2, 13.1±0.2, 14.5±0.2, 17.4±0.2, 18.4±0.2, 20.9±0.2, 24.0±0.2 and 27.5±0.2 degrees two-theta degrees two-theta, and crystalline form S2 of irinotecan free base characterized by a powder X-ray diffraction pattern with peaks at about 7.1±0.2, 10.6±0.2, 12.4±0.2, 20.6±0.2, 21.6±0.2 and 24.2±0.2 degrees two-theta.
    Type: Application
    Filed: March 26, 2020
    Publication date: November 19, 2020
    Inventors: Yuan-Xiu Liao, Yuan-Chang Huang
  • Patent number: 10072039
    Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: September 11, 2018
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20170145001
    Abstract: The present disclosure provides processes for preparing brexpiprazole. The present disclosure also provides processes for the purification of brexpiprazole. The processes for preparing and purifying brexpiprazole of the present invention provide substantial improvements over currently known methods. In certain embodiments, the conversion of Formula XI and XII to form XIII provides increased selectivity over previously reported methods. This offers increased yield and purity. The improved process for purifying brexpiprazole disclosed herein provides brexpiprazole with superior purity and is also more suitable for industrial production.
    Type: Application
    Filed: November 1, 2016
    Publication date: May 25, 2017
    Inventors: Chia-Ying LEE, Shu Ting HUANG, Hsin-Chi WANG, Yuan-Xiu LIAO, Jiunn-Cheh GUO, Lung-Huang KUO
  • Patent number: 9643931
    Abstract: The present invention provides a process for the efficient preparation of enzalutamide.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 9, 2017
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Yuan-Xiu Liao, Jiunn-Cheh Guo, Wen-Li Shih, Shang-Hong Chen
  • Publication number: 20160362381
    Abstract: The present invention provides a process for the efficient preparation of enzalutamide.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 15, 2016
    Inventors: Yuan-Xiu Liao, Jiunn-Cheh Guo, Wen-Li Shih, Shang-Hong Chen
  • Patent number: 9346844
    Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: May 24, 2016
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20150031866
    Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20150031865
    Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Patent number: 8357811
    Abstract: New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: January 22, 2013
    Assignee: ScnioPharm Singapore PTE Ltd.
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Li Lin, Tsung-Yu Hsiao
  • Patent number: 7662980
    Abstract: Anbydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: February 16, 2010
    Assignee: Scinopharm Singapore PTE Ltd.
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Li Lin, Tsung-Yu Hsiao
  • Publication number: 20090275762
    Abstract: New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Application
    Filed: July 13, 2009
    Publication date: November 5, 2009
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Ll Lin, Tsung-Yu Hsiao
  • Publication number: 20080108693
    Abstract: New anhydrous crystalline form of docetaxel and process of making anhydrous docetaxel and docetaxel trihydrate are provided.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 8, 2008
    Applicant: Scinopharm Singapore PTE Ltd.
    Inventors: Yuan-Xiu Liao, Meng-Fen Ho, Shu-Ping Chen, Chia-Ning Lin, Yu-Li Lin, Tsung-Yu Hsiao
  • Publication number: 20060105967
    Abstract: The use of flavone derivatives of formula (I) in which R1, R2, R3, R4 and R5 independently represent hydrogen, hydroxy or an ester group; R6 represents hydrogen, hydroxy, an ester group or an O-glycoside group such as O-rhamnose, O-glucoside, O-retinoside or O-xyloside; and represents a single bond or a double bond; or the pharmaceutically acceptable salts thereof as TNF? antagonists or inhibitors.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Applicant: Advanced Gene Technology, Corp.
    Inventors: Li-Wei Hsu, Su-Chen Chang, Chen-Hsiang Shen, Yuan-Xiu Liao, Kuo-Sheng Chuang