Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.

Abstract: The present application discloses at least an artificial heart valve prosthesis anchoring device comprising a memory metal wire, wherein the memory metal wire is bent and encircled to form a closed loop configured to anchor an artificial heart valve stent, and the closed loop comprises: at least two clamping portions configured to form an expansion force in a radial direction and a restraint force in a circumferential direction to anchor the anchoring device between a heart valve and an adjacent blood vessel wall; and connecting portions that quantitatively correspond to the clamping portions, are alternately arranged with the clamping portions, and are used for transition and connection of adjacent clamping portions.