Patents by Inventor Yuannan Xia

Yuannan Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of DNA constructs for high yield production of polypeptides
    Patent number: 9951368
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: April 24, 2018
    Assignee: Medtronic, Inc.
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • METHODS OF DNA CONSTRUCTS FOR HIGH YIELD PRODUCTION OF POLYPEPTIDES
    Publication number: 20170029860
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Application
    Filed: April 25, 2016
    Publication date: February 2, 2017
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • Methods and DNA constructs for high yield production of polypeptides
    Patent number: 9322025
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: April 26, 2016
    Assignee: Medtronic, Inc.
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • METHOD FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES
    Publication number: 20120156719
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: January 15, 2009
    Publication date: June 21, 2012
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Patent number: 8148508
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: April 3, 2012
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • Methods and constructs for high yield expression of clostripain
    Patent number: 8003362
    Abstract: The invention provides methods and nucleic acid constructs to express clostripain. The source of the coding region for recombinantly expressed clostripain is Clostridium histolyticum.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 23, 2011
    Assignee: Medtronic Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Barton Holmquist
  • METHOD FOR ENZYMATIC PRODUCTION OF GLP-2(1-33) AND GLP-2(1-34) PEPTIDES
    Publication number: 20110130556
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: August 23, 2010
    Publication date: June 2, 2011
    Applicant: NPS PHARMACEUTICALS, INC.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Patent number: 7781567
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 24, 2010
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • METHODS AND DNA CONSTRUCTS FOR HIGH YIELD PRODUCTION OF POLYPEPTIDES
    Publication number: 20090170192
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 2, 2009
    Applicant: RESTORAGEN, INC.
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • Methods and DNA constructs for high yield production of polypeptides
    Patent number: 7501484
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: March 10, 2009
    Assignee: Restoragen, Inc
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • Method for universal enzymatic production of bioactive peptides
    Patent number: 7498148
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: March 3, 2009
    Assignee: Restoragen, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • METHOD FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES
    Publication number: 20080153129
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 21, 2007
    Publication date: June 26, 2008
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Method for universal enzymatic production of bioactive peptides
    Patent number: 7335486
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: February 26, 2008
    Assignee: Restoragen, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Publication number: 20060024778
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: February 2, 2006
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seo
  • Method for universal enzymatic production of bioactive peptides
    Publication number: 20060008870
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: January 12, 2006
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin Merrifield, Mary Bossard, Barton Holmquist, Jin Seo
  • Method for enzymatic production of GLP-1 (7-36) amide peptides
    Publication number: 20050260701
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: November 24, 2005
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Mary Bossard, Barton Holmquist, Edwin Merrifield, Daniel Strydom
  • Methods and constructs for high yield expression of clostripain
    Publication number: 20050244924
    Abstract: The invention provides methods and nucleic acid constructs to express clostripain.
    Type: Application
    Filed: November 24, 2004
    Publication date: November 3, 2005
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Barton Holmquist
  • Methods and DNA constructs for high yield production of polypeptides
    Publication number: 20050239172
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Application
    Filed: November 24, 2004
    Publication date: October 27, 2005
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Barton Holmquist
  • Methods and DNA constructs for high yield production of polypeptides
    Publication number: 20050221444
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Application
    Filed: November 24, 2004
    Publication date: October 6, 2005
    Inventors: James Williams, Peng Luan, Yuannan Xia, Scott Harley
  • Chlorella virus promoters
    Publication number: 20020081735
    Abstract: The present invention provides novel promoter sequences obtained from Chlorella virus. The invention includes gene constructs comprising a promoter sequence of the invention operably linked to a DNA sequence encoding a structural gene. The invention also provides vectors and host cells for expressing product encoded by the structural gene of a gene construct of the invention amd cells transformed with the heterologous gene operably linked to the promoter.
    Type: Application
    Filed: July 9, 2001
    Publication date: June 27, 2002
    Applicant: BioNebraska, Inc.
    Inventor: Yuannan Xia