Patents by Inventor Yuan-Yuan Cheng

Yuan-Yuan Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and Method of Treatment for Heart Protection and Regeneration
    Publication number: 20230151372
    Abstract: The present invention provides a gene delivery vehicle comprising a heterologous genome capable of upregulating the expression of HMGCS2 in human heart and, in particular, in the cardiomyocyte (CM). Upregulating the expression of HMBCS2 causes a metabolic switch that facilitates CM dedifferentiation and regeneration under myocardial infarction or hypoxic conditions. The present invention also provides a method of therapy for protection and/or regeneration of the human heart and, in particular, in the CM by administration of the composition of the present invention to the patient.
    Type: Application
    Filed: October 7, 2022
    Publication date: May 18, 2023
    Applicant: Academia Sinica
    Inventors: Patrick Ching-Ho Hsieh, Yuan-Yuan Cheng
  • Therapeutic gene cocktail for heart regeneration
    Patent number: 10398786
    Abstract: A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: September 3, 2019
    Assignee: Academia Sinica
    Inventors: Patrick C. H. Hsieh, Yuan-Yuan Cheng
  • A THERAPEUTIC GENE COCKTAIL FOR HEART REGENERATION
    Publication number: 20180099056
    Abstract: A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.
    Type: Application
    Filed: April 19, 2016
    Publication date: April 12, 2018
    Applicant: Academia Sinica
    Inventors: Patrick C.H. Hsieh, Yuan-Yuan Cheng