Abstract: The present application provides a detection system and a detection method of genomic carcinogenesis information based on cell-free DNA, particularly plasma cell-free DNA. The system includes a library construction apparatus, a sequencing apparatus and an information analysis apparatus, the library construction apparatus is configured to convert 5-methylcytosine (5-mC) in the cell-free DNA in a to-be-detected sample into 5-formylcytosine (5-fC) and 5-carboxycytosine (5-caC) and convert non-methylated cytosine (C) into uracil (U) by using enzymes, and the information analysis apparatus is capable of analyzing methylation density of genome, fragment size distribution, fragment 5? end motif and/or chromosome stability. With the adoption of the system and the method, early, sensitive and accurate detection and screening of various cancers can be synchronously implemented.

Abstract: A data transmission method includes running a first application program on a first terminal, responding to an operation request for a document in the first application program to acquire a request object identifier and a document identifier of the document; acquiring a permission object group identifier of the document according to the document identifier, sending a permission authentication request for the request object identifier to the second application program, the permission authentication request being used to trigger the second application program to perform authentication processing on the request object identifier according to the permission object group identifier and return an authentication result, and outputting a response page of the operation request according to the authentication result returned from the second application program.

Abstract: A document editing method includes: displaying a shared document page including content of a target shared document and description information of document insertion content. The target shared document and the document insertion content are from different content platforms. The method includes displaying a link editing page of the document insertion content in response to an editing operation on the description information of the document insertion content; acquiring target link address information edited through the link editing page; and updating the document insertion content to target content corresponding to the target link address information.

Abstract: Embodiments of the invention provides methods for determining a methylation score of DNA and determining a ctDNA Fraction (CTDF) value. Additional embodiments are as described herein.

Abstract: Disclosed are a next generation sequencing-based detection panel for glioma, a detection kit, a detection method and an application thereof. The detection panel contains glioma-related genes and loci, wherein the glioma-related genes and loci contain SNP locus on chromosome 1, SNP locus on chromosome 19, MGMT, ATRX, H3F3A, ACVR1, CTC, HIST1H3B, MLH1, PLCG1, SMO, AKT1, CTNNB1, HIST1H3C, MSH2, PMS2, TERT, ATRX, DAXX, HRAS, MSH6, PPMID, TP53, BCOR, DDX3X, IDH1, MYC, PTCH1 and the like.

Abstract: A device and a method for detecting tumor mutation burden (TMB) based on capture sequencing are disclosed. The device includes: a panel design module configured to uniformly add population single-nucleotide polymorphism (SNP) sites to a genome and screen out gene regions that show the highest consistency with whole exome sequencing (WES); a data acquisition module configured to acquire tissue and plasma samples of a target object and acquire sequencing data of the samples; an alignment module configured to align the sequencing data with a reference genome to acquire mutation data results; a somatic mutation analysis module configured to perform somatic analysis on the mutation data results to obtain somatic mutation results; a filtering module configured to remove unreal mutation sites from the somatic mutation results; and a calculation module configured to calculate the TMB.