Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.

Abstract: A polypeptide comprising a chimeric antigen receptor (CAR) comprising (i) an extracellular domain capable of binding to a first antigen, (ii) a transmembrane domain, and (iii) an intracellular domain; and a domain capable of binding to a second antigen expressed on the surface of a cell that can interact with a T cell, wherein the CAR and the domain are fused by a peptide linker.

Abstract: The present application provides GPC2-specific antibodies and antigen binding fragments thereof. A chimeric antigen receptor (CAR) that specifically binds glypican-2 (GPC2) comprising a GPC2-specific antibody, a transmembrane domain, and an intracellular signaling domain. T cells comprising the disclosed CAR constructs can be used for cancer immunotherapy.

Abstract: Provided herein are anti-DLL3 chimeric antigen receptors (CARs), DLL3 binding proteins and uses of such CARs or DLL3 binding proteins in the treatment of DLL3 associated disorders, such as small cell lung cancer.

Abstract: CD30-binding moieties, chimeric antigen receptors (CARs) having these CD30-binding moieties, and uses thereof are provided. Polynucleotides encoding the CD30-binding moieties and CARs, compositions comprising CD30-binding moieties and CARs, genetically modified immune cells having a chimeric antigen receptor for use in adoptive cell therapy for treating CD30-expressing cancer or tumor in a subject in need thereof are also provided herein.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: Embodiments of this application disclose a data transmission method and a related apparatus. The method in the embodiments of this application includes: obtaining a set of link information and a set of indication information of at least two links, where the link information is used to indicate a sender of a radio frame transmitted on a link, a receiver of the radio frame, and a transmission time interval of the radio frame, the indication information is used to indicate whether the receiver successfully receives the radio frame transmitted on the link, and transmission time intervals of radio frames transmitted on all of the at least two links have an overlapping target time interval; and determining a target link group based on the set of link information and the set of indication information of the at least two links.

Abstract: Embodiments of this application disclose a data transmission method and a related apparatus. The method in the embodiments of this application includes: obtaining a set of link information and a set of indication information of at least two links, where the link information is used to indicate a sender of a radio frame transmitted on a link, a receiver of the radio frame, and a transmission time interval of the radio frame, the indication information is used to indicate whether the receiver successfully receives the radio frame transmitted on the link, and transmission time intervals of radio frames transmitted on all of the at least two links have an overlapping target time interval; and determining a target link group based on the set of link information and the set of indication information of the at least two links.

Abstract: A lifecycle dynamic modeling system includes a user device that includes a controller, a database, and a memory within the wireless device and in communication with the controller. The memory includes program instructions executable by the controller that, when executed by the controller, cause the controller to receive data from the database, wherein the data includes a plurality of data points over a period of time, divide the data into a plurality of vintages based on time periods, divide each of the vintages in a plurality of vintages into a plurality of segmented-vintage cohorts based on one or more attributes of the data, and determine a score based on a modeling rate that varies over time, wherein the modeling rate is based on the plurality of segmented-vintage cohorts.

Abstract: An Ethernet Switch Ring (ESR) protection method for introducing the pre-up state for the transit node, includes, after a loop failure is recovered, the transit node on the loop entering the pre-up state if not receiving the loop failure protocol message within a set time. And when the transit node is in the pre-up state and the loop fails again, i.e., the transit node receives the loop failure protocol message in the pre-up state, the transit node opens the master and slave ports and refreshes the MAC address. Effectively, the transit node is an ESR transit node.

Abstract: The present invention discloses an Ethernet Switch Ring (ESR) protection method, for introducing the pre-up state for the transit node, comprising, after the loop failure is recovered, the transit node on the loop will enter the pre-up state if not receiving the loop failure protocol message within the set time; and when the transit node is in the pre-up state and the loop is failed again, i.e., the transit node receives the loop failure protocol message in the pre-up state, the transit node opens the master and slave ports and refreshes the MAC address. Correspondingly, the present invention further discloses an ESR transit node. Since the pre-up state is introduced for the transit node and the transit node controls whether to open the recovered failed port by itself, the unsmooth flow caused by the master node which cannot notify the recovered failed port to open is avoided, and the ring network protection capability and user experience can be improved.