Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.

Abstract: A container-type apparatus for wastewater treatment with a suspended particle system, including one or multiple biological reaction zones. The biological reaction zones can be facultative, anaerobic, anoxic, and aerobic and at least one of the biological reaction zones is a suspended particle system. Particles in the suspended particle system act as the carrier of microbiota and offer better conditions for them to grow. The apparatus adopts a box structure, such as a container type, which is convenient to move, flexible to assemble, and can be used multiple times. Based on actual requirements, this apparatus can also be a structure type. The suspended particle system can increase the concentration of microorganisms significantly, improve the ability to bear impact load, produce less sludge, and without sludge expansion.

Abstract: The present invention provides a cage particle distribution system for wastewater treatment comprising contactors. Said contactors include shells and the interior of said shells is a hollow cavity. At least one of the side walls, the upper surface and the lower surface of said shells are equipped with through-holes. Particles are loaded inside said shells and said particles can carry some microorganisms on their surfaces at least. Said cage systems are placed in the water of a wastewater system or a wastewater treatment system and one or multiple said cage systems can be placed. Separate aeration and/or liquid distribution into each individual cage system disperse particles in the system by the gas and/or liquid, which improves the efficiency of wastewater treatment.

Abstract: The present invention provides a cage particle distribution system for wastewater treatment comprising contactors. Said contactors include shells and the interior of said shells is a hollow cavity. At least one of the side walls, the upper surface and the lower surface of said shells are equipped with through-holes. Particles are loaded inside said shells and said particles can carry some microorganisms on their surfaces at least. Said cage systems are placed in the water of a wastewater system or a wastewater treatment system and one or multiple said cage systems can be placed. Separate aeration and/or liquid distribution into each individual cage system disperse particles in the system by the gas and/or liquid, which improves the efficiency of wastewater treatment.

Abstract: The present disclosure provides a light particle system or a mixed particle system for wastewater treatment comprising a contactor. The contactor includes a gas-liquid-solid three-phase region, and the gas-liquid-solid three-phase region includes gas phase, liquid phase, and solid phase. The liquid phase is a continuous phase and the solid phase is light particles or mixed particles. The mixed particles include light particles and heavy particles. The density of the light particles is lower than the density of the liquid phase and the density of the heavy particles is higher than the density of the liquid phase. The light particles or mixed particles are able to carry some microorganisms on their surfaces at least. The light/mixed particle-suspension system in the present invention applied in wastewater treatment can increase the concentration of microorganisms significantly, improve the ability to bear impact load, produce less sludge, and without sludge expansion.

Abstract: The present disclosure discloses a slightly heavy particle system for wastewater treatment, comprising a contactor. Said contactor includes a gas-liquid-solid three-phase region, and said gas-liquid-solid three-phase region includes gas phase, liquid phase, and solid phase. Said liquid phase is the continuous phase and said solid phase is slightly heavy particles. Said slightly heavy particles are able to carry some microorganisms on their surfaces at least, and the density of said slightly heavy particles is higher than the density of said liquid. The slightly heavy particle system of the present disclosure applied in wastewater treatment can increase the concentration of microorganisms significantly, improve the ability to bear impact load, produce less sludge, and without sludge expansion. Meanwhile, the means to suspend slightly heavy particles with the combined effect of gas and liquid is able to reduce energy consumption to a larger extent.

Abstract: The present disclosure provides a container-type apparatus for wastewater treatment with a suspended particle system, including one or multiple biological reaction zones. Said biological reaction zones can be facultative, anaerobic, anoxic, and aerobic and at least one of said biological reaction zones is a suspended particle system. Particles in said suspended particle system act as the carrier of microbiota and offer better conditions for them to grow. The apparatus adopts a box structure, such as a container type, which is convenient to move, flexible to assemble, and can be used for multiple times. Based on actual requirements, this apparatus can also be a structure type. The suspended particle system disclosed herein applied in wastewater treatment can increase the concentration of microorganisms significantly, improve the ability to bear impact load, produce less sludge, and without sludge expansion.