Abstract: The present disclosure relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.

Abstract: The present disclosure relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.

Abstract: Methods and systems are described for removing carbon dioxide from the atmosphere by adding CO2-reactive chemical base to a body of water in contact with the atmosphere, and determining the quantity of carbon dioxide removed from the atmosphere or prevented from reaching the atmosphere. The alkalinity addition to the body of water is controlled by a dosing apparatus capable of determining an amount of CO2-reactive alkalinity required for achieving a permissible target carbon dioxide removal. A rate of alkalinity flow is affected by input from sensors that monitor conditions in the body of water.

Abstract: Provided are a face image processing method and apparatus, an image device, and a storage medium. The face image processing method includes: acquiring first-key-point information of a first face image; performing position transformation on the first-key-point information to obtain second-key-point information conforming to a second facial geometric attribute, the second facial geometric attribute being different from a first facial geometric attribute corresponding to the first-key-point information; and performing facial texture coding processing by utilizing a neural network and the second-key-point information to obtain a second face image.

Abstract: A foamable silicone composition, includes: (a) at least one organopolysiloxane containing at least two alkenyl groups bonded to silicon atoms per molecule, (b) at least one organopolysiloxane containing at least two hydrogen atoms bonded to silicon atoms per molecule, (c) porogenic agents generating gaseous hydrogen in the presence of component (b) comprising (c1) an organopolysiloxane containing at least one hydroxyl group bonded to silicon atom per molecule and (c2) water, and (d) hydrosilylation catalyst; with the proviso that the ratio of the number of moles of hydroxyl groups provided by component (c2) to that provided by component (c1) is within a range of from 1:5 to 20:1. The composition has a low viscosity and a relatively high pot life, and the foam cured therefrom has a low density, uniform porosity and fine cell structure.

Abstract: Embodiments of the present disclosure provide a display data processing method, device and terminal, a display method and device and a readable storage medium. The display data processing method includes: acquiring a display data saving instruction; and storing, when a display screen deforms, display data and a state parameter of display screen corresponding to the display screen to obtain a display data processing result.

Abstract: Foamable silicone compositions, containing (A) at least one organopolysiloxane containing at least two alkenyl groups bonded to silicon per molecule, (B) at least one organopolysiloxane containing at least two hydrogen atoms bonded to silicon per molecule, (C) at least one porogenic agent generating gaseous hydrogen in the presence of component (B), and (D) at least one hydrosilylation catalyst. Foams obtained by curing such foamable silicone compositions have excellent resilience, moderate hardness, good mechanical properties, and flame retardancy, suitable for the sealing of battery pack cases.

Abstract: Embodiments of the present disclosure provide a display data processing method, device and terminal, a display method and device and a readable storage medium. The display data processing method includes: acquiring a display data saving instruction; and storing, when a display screen deforms, display data and a state parameter of display screen corresponding to the display screen to obtain a display data processing result.

Abstract: The present invention belongs to the field of immunology and molecular biology, which relates to an anti-PCSK9 antibody, the pharmaceutical composition and method of use thereof. In particular, the present invention relates to the monoclonal antibody, which can bind PCSK9 specifically, block association of PCSK9 with LDLR, upregulate the amount of LDLR on cell surface, heighten the metabolism of LDL cholesterol and/or triglycerides, and prevent/treat cardiovascular diseases caused by hypercholesterolemia.

Abstract: Provided are a face image processing method and apparatus, an image device, and a storage medium. The face image processing method includes: acquiring first-key-point information of a first face image; performing position transformation on the first-key-point information to obtain second-key-point information conforming to a second facial geometric attribute, the second facial geometric attribute being different from a first facial geometric attribute corresponding to the first-key-point information; and performing facial texture coding processing by utilizing a neural network and the second-key-point information to obtain a second face image.

Abstract: The present invention relates to a CRISPR/Cas system comprising guide RNAs and a Cas protein, wherein the guide RNAs are composed of the following two parts: the guide RNAs are capable of respectively binding to two sequences of target sequences having SEQ ID NO: 2, SEQ NO: 3 and SEQ ID NO: 4 in eukaryotic B2M genes. The system exhibits a relatively high single-gene knockout rate for B2M. The present invention further relates to a gene editing method for T cells using the system, which method provides an efficient, safe and simple process for producing universal T cells.

Abstract: Provided are a substituted tricyclic heterocyclic compound of formula I or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt, ester or a prodrug thereof, a pharmaceutical composition including the same and uses thereof. The substituted tricyclic heterocyclic compounds and the pharmaceutical compositions comprising the compounds disclosed herein can be used for treating a disorder caused by at least one of cancer and neurodegenerative diseases. Further the compounds and the pharmaceutical compositions comprising the compounds disclosed herein can be also used for preventing or treating a disorder caused by, associated with or accompanied by any abnormal kinase activity.

Abstract: The present invention belongs to the field of immunology and molecular biology, which relates to an anti-PCSK9 antibody, the pharmaceutical composition and method of use thereof. In particular, the present invention relates to the monoclonal antibody, which can bind PCSK9 specifically, block association of PCSK9 with LDLR, upregulate the amount of LDLR on cell surface, heighten the metabolism of LDL cholesterol and/or triglycerides, and prevent/treat cardiovascular diseases caused by hypercholesterolemia.

Abstract: The present invention belongs to the field of immunology and molecular biology, which relates to an anti-PCSK9 antibody, the pharmaceutical composition and method of use thereof. In particular, the present invention relates to the monoclonal antibody, which can bind PCSK9 specifically, block association of PCSK9 with LDLR, upregulate the amount of LDLR on cell surface, heighten the metabolism of LDL cholesterol and/or triglycerides, and prevent/treat cardiovascular diseases caused by hypercholesterolemia.

Abstract: Provided are a substituted tricyclic herteocyclic compound of formula I or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt, ester or a prodrug thereof, a pharmaceutical composition including the same and uses thereof. The substituted tricyclic herteocyclic compounds and the pharmaceutical compositions comprising the compounds disclosed herein can be used for treating a disorder caused by at least one of cancer and neurodegenerative diseases. Further the compounds and the pharmaceutical compositions comprising the compounds disclosed herein can be also used for preventing or treating a disorder caused by, associated with or accompanied by any abnormal kinase activity.

Abstract: Disclosed are an indication direction-based instruction transmission method and apparatus, a smart device and a storage medium. According to the method, after a first smart device receives a first instruction, a current orientation of a set orientation on the first smart device is determined. It is detected whether there is at least one second smart device in the current orientation or not, and a first detection result is generated. When the first detection result represents that there is at least one second smart device in the current orientation, the first instruction is sent to at least one second smart device in the detected at least one second smart device to enable the at least one second smart device receiving the first instruction to execute the first instruction.

Abstract: A method, system, and device for processing video shooting are described. The method includes: shooting a subject in a background sample, the background sample, and a target background respectively, to generate a first video recording the subject and the background sample, a second video recording the background sample, and a third video recording the target background respectively, the shooting time lengths of the first video and the second video being smaller than the shooting time length of the third video; and comparing the first video and the second video, extracting images of the subject from the first video, generating a subject image frame sequence with a transparent background, sequentially superimposing each subject image frame in the subject image frame sequence to the third video, and generating a video file recording the subject and the target background.

Abstract: Disclosed are an indication direction-based instruction transmission method and apparatus, a smart device and a storage medium. According to the method, after a first smart device receives a first instruction, a current orientation of a set orientation on the first smart device is determined. It is detected whether there is at least one second smart device in the current orientation or not, and a first detection result is generated. When the first detection result represents that there is at least one second smart device in the current orientation, the first instruction is sent to at least one second smart device in the detected at least one second smart device to enable the at least one second smart device receiving the first instruction to execute the first instruction.

Abstract: A method and device for reminding contact modes are disclosed. In some embodiments, the method includes: a calling end initiates a call and detects a call state of a call; and interaction information used for inquiring whether to send a short message to a current call number is displayed if a detected call state shows that a called end is busy.

Abstract: Disclosed are a video recording apparatus and a photographing method thereof. The method includes: enabling a video recording mode when the video recording apparatus is powered on, and slowly playing a recorded video at a set speed during recording; and capturing a video image at a moment of triggering to obtain a photograph when a user triggers photographing.