Abstract: The present application provides a composition of oral soluble film and application thereof. The composition includes a film-forming agent, a plasticizing agent, and a target releasing substance. The film-forming agent includes pectin and polysaccharide backbones. The flexibility and mechanical strength of the oral soluble film may meet the production requirements during cutting and packaging processes, the adhesion force, the dissolving time limit, and the dissolving rate of the active components may also meet usage needs.

Abstract: Disclosed in the present application is a cooling pipe structure, a liquid cooling plate, and a battery system, including: a cooling pipe set, in which the cooling pipe set comprises at least one cooling pipe, a flow direction of liquid in the cooling pipe is defined as a first direction, the cooling pipes are arranged in a tree-like structure from a side to an opposite side along the first direction, a side of the tree-like structure is a tree-like beginning, and an opposite side thereof is a tree-like end; a pipe inlet, in which the pipe inlet is in communication with a side of the tree-like beginning of the cooling pipe in the cooling pipe set; and a pipe outlet, in which the pipe outlet is in communication with a side of the tree-like end of the cooling pipe in the cooling pipe set.

Abstract: The present application provide a battery pack and a vehicle, the battery pack includes a battery module and a cooling plate. The battery module includes a plurality of battery cells having respective pressure release valves, and the pressure release valves are located in a pressure release region. The cooling plate is disposed above the battery cells, and the cooling plate is provided with a cooling channel therein. The cooling plate is provided with a protruding portion, a protruding direction of the protruding portion is away from the battery cells, the protruding portion is provided at a position corresponding to the pressure release region, and the protruding portion is provided with a plurality of exhaust vents disposed at respective positions corresponding to the pressure release valves.

Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: The present invention belongs to the field of diagnosis and treatment of tumors, and relates to a HIF-2? small-molecule inhibitor and use thereof in treatment of tumors such as breast cancer and ovarian cancer. The small-molecule inhibitor is a compound represented by formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or prodrug of the compound represented by formula (I). The small-molecule inhibitor mainly inhibits the proliferation of tumor cells by inhibiting HIF-2? protein, and can also inhibit the growth of CSCs with high expression of HIF-2?. The small-molecule inhibitor can be used as a novel anti-tumor drug to completely eliminate tumors and stem cells, and has broad application prospects.

Abstract: The present invention belongs to the field of diagnosis and treatment of tumors, and relates to a HIF-2? small-molecule inhibitor and use thereof in treatment of tumors such as breast cancer and ovarian cancer. The small-molecule inhibitor is a compound represented by formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or prodrug of the compound represented by formula (I). The small-molecule inhibitor mainly inhibits the proliferation of tumor cells by inhibiting HIF-2? protein, and can also inhibit the growth of CSCs with high expression of HIF-2?. The small-molecule inhibitor can be used as a novel anti-tumor drug to completely eliminate tumors and stem cells, and has broad application prospects.

Abstract: A continuous annealing method for low coercive force cold-rolled electromagnetic pure iron plate and strip. Control parameters of each stages in a continuous annealing process are as follows: 750-850° C. at a heating stage; 750-850° C. at a soaking stage, the soaking time is 100-150 s; an outlet temperature of 575-675° C. at a slow-cooling stage, the cooling speed in slow-cooling stage is 2.5-10° C./s; an outlet temperature of 380-420° C. at a fast-cooling stage, the cooling speed of the fast-cooling stage is 15-25° C./s; and 270-310° C. at an overaging stage. The annealing medium is a non-oxidizing atmosphere composed of H2 and N2. After annealing, the cold-rolled electromagnetic pure iron plate and strip is leveled and pressed such that the leveling elongation rate of the plate and strip is controlled within the range of 0.2±0.1%.

Abstract: Embodiments of the present invention provide a data transmission method, user equipment, and a base station. The method can include receiving, by user equipment, indication information for stopping transmission sent by a base station, where the indication information for stopping transmission is configured to instruct the user equipment to stop transmitting uplink data for at least one service by through an access point AP of a wireless local area network WLAN. The method can also include stopping, by the user equipment according to the indication information for stopping transmission, transmitting the uplink data for the at least one service through the AP. In this process, the user equipment reduces a data volume of uplink data transmitted through the WLAN, so as to decrease a probability that an uplink data collision occurs in the WLAN, thereby improving service quality.

Abstract: A continuous annealing method for low coercive force cold-rolled electromagnetic pure iron plate and strip. Control parameters of each stages in a continuous annealing process are as follows: 750-850° C. at a heating stage; 750-850° C. at a soaking stage, the soaking time is 100-150 s; an outlet temperature of 575-675° C. at a slow-cooling stage, the cooling speed in slow-cooling stage is 2.5-10° C./s; an outlet temperature of 380-420° C. at a fast-cooling stage, the cooling speed of the fast-cooling stage is 15-25° C./s; and 270-310° C. at an overaging stage. The annealing medium is a non-oxidizing atmosphere composed of H2 and N2. After annealing, the cold-rolled electromagnetic pure iron plate and strip is leveled and pressed such that the leveling elongation rate of the plate and strip is controlled within the range of 0.2±0.1%.

Abstract: Embodiments of the present invention provide a data transmission method, user equipment, and a base station. The method can include receiving, by user equipment, indication information for stopping transmission sent by a base station, where the indication information for stopping transmission is configured to instruct the user equipment to stop transmitting uplink data for at least one service by through an access point AP of a wireless local area network WLAN. The method can also include stopping, by the user equipment according to the indication information for stopping transmission, transmitting the uplink data for the at least one service through the AP. In this process, the user equipment reduces a data volume of uplink data transmitted through the WLAN, so as to decrease a probability that an uplink data collision occurs in the WLAN, thereby improving service quality.