Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: The present invention belongs to the field of diagnosis and treatment of tumors, and relates to a HIF-2? small-molecule inhibitor and use thereof in treatment of tumors such as breast cancer and ovarian cancer. The small-molecule inhibitor is a compound represented by formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or prodrug of the compound represented by formula (I). The small-molecule inhibitor mainly inhibits the proliferation of tumor cells by inhibiting HIF-2? protein, and can also inhibit the growth of CSCs with high expression of HIF-2?. The small-molecule inhibitor can be used as a novel anti-tumor drug to completely eliminate tumors and stem cells, and has broad application prospects.

Abstract: The present invention belongs to the field of diagnosis and treatment of tumors, and relates to a HIF-2? small-molecule inhibitor and use thereof in treatment of tumors such as breast cancer and ovarian cancer. The small-molecule inhibitor is a compound represented by formula (I) or a stereoisomer, pharmaceutically acceptable salt, solvate or prodrug of the compound represented by formula (I). The small-molecule inhibitor mainly inhibits the proliferation of tumor cells by inhibiting HIF-2? protein, and can also inhibit the growth of CSCs with high expression of HIF-2?. The small-molecule inhibitor can be used as a novel anti-tumor drug to completely eliminate tumors and stem cells, and has broad application prospects.

Abstract: A continuous annealing method for low coercive force cold-rolled electromagnetic pure iron plate and strip. Control parameters of each stages in a continuous annealing process are as follows: 750-850° C. at a heating stage; 750-850° C. at a soaking stage, the soaking time is 100-150 s; an outlet temperature of 575-675° C. at a slow-cooling stage, the cooling speed in slow-cooling stage is 2.5-10° C./s; an outlet temperature of 380-420° C. at a fast-cooling stage, the cooling speed of the fast-cooling stage is 15-25° C./s; and 270-310° C. at an overaging stage. The annealing medium is a non-oxidizing atmosphere composed of H2 and N2. After annealing, the cold-rolled electromagnetic pure iron plate and strip is leveled and pressed such that the leveling elongation rate of the plate and strip is controlled within the range of 0.2±0.1%.

Abstract: Embodiments of the present invention provide a data transmission method, user equipment, and a base station. The method can include receiving, by user equipment, indication information for stopping transmission sent by a base station, where the indication information for stopping transmission is configured to instruct the user equipment to stop transmitting uplink data for at least one service by through an access point AP of a wireless local area network WLAN. The method can also include stopping, by the user equipment according to the indication information for stopping transmission, transmitting the uplink data for the at least one service through the AP. In this process, the user equipment reduces a data volume of uplink data transmitted through the WLAN, so as to decrease a probability that an uplink data collision occurs in the WLAN, thereby improving service quality.

Abstract: A continuous annealing method for low coercive force cold-rolled electromagnetic pure iron plate and strip. Control parameters of each stages in a continuous annealing process are as follows: 750-850° C. at a heating stage; 750-850° C. at a soaking stage, the soaking time is 100-150 s; an outlet temperature of 575-675° C. at a slow-cooling stage, the cooling speed in slow-cooling stage is 2.5-10° C./s; an outlet temperature of 380-420° C. at a fast-cooling stage, the cooling speed of the fast-cooling stage is 15-25° C./s; and 270-310° C. at an overaging stage. The annealing medium is a non-oxidizing atmosphere composed of H2 and N2. After annealing, the cold-rolled electromagnetic pure iron plate and strip is leveled and pressed such that the leveling elongation rate of the plate and strip is controlled within the range of 0.2±0.1%.

Abstract: Embodiments of the present invention provide a data transmission method, user equipment, and a base station. The method can include receiving, by user equipment, indication information for stopping transmission sent by a base station, where the indication information for stopping transmission is configured to instruct the user equipment to stop transmitting uplink data for at least one service by through an access point AP of a wireless local area network WLAN. The method can also include stopping, by the user equipment according to the indication information for stopping transmission, transmitting the uplink data for the at least one service through the AP. In this process, the user equipment reduces a data volume of uplink data transmitted through the WLAN, so as to decrease a probability that an uplink data collision occurs in the WLAN, thereby improving service quality.