Patents by Inventor Yuanyuan ZHA

Yuanyuan ZHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240102107
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Application
    Filed: October 19, 2023
    Publication date: March 28, 2024
    Applicant: The University of Chicago
    Inventors: Yan ZHENG, Yuanyuan ZHA, Robbert M. SPAAPEN, Thomas F. GAJEWSKI
  • Patent number: 11802316
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: October 31, 2023
    Assignee: The University of Chicago
    Inventors: Yan Zheng, Yuanyuan Zha, Robbert M. Spaapen, Thomas F. Gajewski
  • Publication number: 20210139994
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Application
    Filed: September 18, 2020
    Publication date: May 13, 2021
    Applicant: The University of Chicago
    Inventors: Yan ZHENG, Yuanyuan ZHA, Robbert M. SPAAPEN, Thomas F. GAJEWSKI
  • Patent number: 10815531
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: October 27, 2020
    Assignee: The University of Chicago
    Inventors: Yan Zheng, Yuanyuan Zha, Robbert M. Spaapen, Thomas F. Gajewski
  • Publication number: 20180312929
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Application
    Filed: March 27, 2018
    Publication date: November 1, 2018
    Inventors: Yan ZHENG, Yuanyuan ZHA, Robbert M. SPAAPEN, Thomas F. GAJEWSKI
  • Patent number: 9944992
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of costimulation (Schwartz, 2003). Anergy induction was initially observed in vitro using chemically-fixed antigen presenting cells (APCs). Subsequently, it was found that anergy could be induced by immobilized anti-CD3 mAb or calcium ionophores (such as ionomycin) in vitro, and by superantigen and soluble antigenic peptide in vivo. Indirect evidence has suggested that T cell dysfunction in the tumor microenvironment and establishment of transplant tolerance is partially due to T cell anergy (Gajewski et al., 2011).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 17, 2018
    Assignee: The University of Chicago
    Inventors: Yan Zheng, Yuanyuan Zha, Robbert M. Spaapen, Thomas F. Gajewski
  • Publication number: 20160024593
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of costimulation (Schwartz, 2003). Anergy induction was initially observed in vitro using chemically-fixed antigen presenting cells (APCs). Subsequently, it was found that anergy could be induced by immobilized anti-CD3 mAb or calcium ionophores (such as ionomycin) in vitro, and by superantigen and soluble antigenic peptide in vivo. Indirect evidence has suggested that T cell dysfunction in the tumor microenvironment and establishment of transplant tolerance is partially due to T cell anergy (Gajewski et al., 2011).
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Yan ZHENG, Yuanyuan ZHA, Robert M. SPAAPEN, Thomas F. GAJEWSKI