Patents by Inventor Yuanzheng He

Yuanzheng He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structures and mechanism for the design of highly potent glucocorticoids
    Patent number: 10954265
    Abstract: The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: March 23, 2021
    Assignee: VAN ANDEL RESEARCH INSTITUTE
    Inventors: Huaqiang Eric Xu, Yuanzheng He
  • STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS
    Publication number: 20190263853
    Abstract: The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.
    Type: Application
    Filed: October 13, 2017
    Publication date: August 29, 2019
    Inventors: Huaqiang Eric Xu, Yuanzheng He
  • Highly potent glucocorticoids
    Patent number: 9975918
    Abstract: The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 22, 2018
    Assignees: VAN ANDEL RESEARCH INSTITUTE, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Huaqiang Eric Xu, Yuanzheng He, Karsten Melcher, Wei Yi, Jingjing Shi
  • Highly Potent Glucocorticoids
    Publication number: 20160251393
    Abstract: The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compounds, and uses thereof.
    Type: Application
    Filed: September 25, 2014
    Publication date: September 1, 2016
    Inventors: Huaqiang Eric XU, Yuanzheng HE, Karsten MELCHER, Wei YI, Jingling SHI
  • Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
    Patent number: 8173670
    Abstract: A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: May 8, 2012
    Assignee: Van Andel Research Institute
    Inventors: Huaqiang Eric Xu, Yong Xu, Yuanzheng He
  • METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS
    Publication number: 20110251211
    Abstract: A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.
    Type: Application
    Filed: January 13, 2010
    Publication date: October 13, 2011
    Inventors: Huaqiang Eric Xu, Yong Xu, Yuanzheng He
  • COMPOSITIONS OF A V-ATPASE INHIBITOR IN COMBINATION WITH A GLUCOCORTICOID RECEPTOR LIGAND AND METHODS OF USE
    Publication number: 20110237497
    Abstract: A composition of a glucocorticoid receptor (GR) ligand, or analog thereof, and a V-ATPase inhibitor, or analog thereof. A method for administering such composition to a cell either to increase glucocorticoid transrepression activity or to increase glucocorticoid transactivation activity in the cell. Also, a method for treating a subject having an inflammatory or auto-immune disease by administering such composition.
    Type: Application
    Filed: November 18, 2010
    Publication date: September 29, 2011
    Inventors: HUAQIANG ERIC XU, Yong Xu, Yuanzheng He
  • Cofactor that modulates steroid receptor activities
    Patent number: 7867500
    Abstract: The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ribozyme and siRNA STAMP nucleic acids that can modulate the expression of STAMP. Also provided are compositions and methods for modulating glucocorticoid-responsive gene expression and for treating a variety of diseases and conditions.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: January 11, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: S. Stoney Simons, Jr., Yuanzheng He
  • METHODS OF USING SUBSTITUTED ISOXAZOLO PYRIDINONES AS DISSOCIATED GLUCOCORTICOIDS
    Publication number: 20100179167
    Abstract: A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid receptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.
    Type: Application
    Filed: January 13, 2010
    Publication date: July 15, 2010
    Inventors: Huaqiang Eric Xu, Yong Xu, Yuanzheng He
  • Novel cofactor that modulates steroid receptor activities
    Publication number: 20070128627
    Abstract: The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ribozyme and siRNA STAMP nucleic acids that can modulate the expression of STAMP. Also provided are compositions and methods for modulating glucocorticoid-responsive gene expression and for treating a variety of diseases and conditions.
    Type: Application
    Filed: August 25, 2006
    Publication date: June 7, 2007
    Inventors: S. Simons, Yuanzheng He