Patents by Inventor Yuanzheng Zhang
Yuanzheng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10711061Abstract: The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.Type: GrantFiled: February 12, 2018Date of Patent: July 14, 2020Assignee: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Publication number: 20200109212Abstract: The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties. The document relates to epitopes of canine PD-L that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes, and to the use of the caninized anti-canine PD-L1 antibodies in the treatment of cancer in dogs.Type: ApplicationFiled: December 18, 2019Publication date: April 9, 2020Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Patent number: 10550194Abstract: The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties. The document relates to epitopes of canine PD-L1 that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes, and to the use of the caninized anti-canine PD-L1 antibodies in the treatment of cancer in dogs.Type: GrantFiled: September 29, 2015Date of Patent: February 4, 2020Assignee: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Publication number: 20190002562Abstract: The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies against canine PD-1 that have a high binding affinity for canine PD-1. The invention further discloses the use of the caninized antibodies of the present invention in the treatment of cancer in dogs.Type: ApplicationFiled: September 13, 2018Publication date: January 3, 2019Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Ian Tarpey
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Publication number: 20180371097Abstract: The present invention provides caninized human anti-human IL-4R? antibodies that have specific sequences and a high binding affinity for canine IL-4R?. The invention also relates to use of these antibodies in the treatment of dogs against atopic dermatitis.Type: ApplicationFiled: December 15, 2016Publication date: December 27, 2018Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang
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Publication number: 20180346580Abstract: The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor ?. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.Type: ApplicationFiled: April 1, 2016Publication date: December 6, 2018Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang
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Publication number: 20180346570Abstract: The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The invention also relates to use of these antibodies in the treatment of dogs.Type: ApplicationFiled: June 13, 2018Publication date: December 6, 2018Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey, Leonard Presta
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Patent number: 10106607Abstract: The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies againstcanine PD-1 that have a high binding affinity for canine PD-1. The invention further discloses the use of the caninized antibodies of the present invention in the treatment of cancer in dogs.Type: GrantFiled: December 19, 2014Date of Patent: October 23, 2018Assignee: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Ian Tarpey
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Publication number: 20180251554Abstract: The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.Type: ApplicationFiled: February 12, 2018Publication date: September 6, 2018Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Publication number: 20180237535Abstract: The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties. The document relates to epitopes of canine PD-L1 that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes, and to the use of the caninized anti-canine PD-L1 antibodies in the treatment of cancer in dogs.Type: ApplicationFiled: September 29, 2015Publication date: August 23, 2018Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Patent number: 10023636Abstract: The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The invention also relates to use of these antibodies in the treatment of dogs.Type: GrantFiled: December 19, 2014Date of Patent: July 17, 2018Assignee: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey, Leonard G. Presta
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Patent number: 9944704Abstract: The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.Type: GrantFiled: December 19, 2014Date of Patent: April 17, 2018Assignee: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Publication number: 20160333096Abstract: The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.Type: ApplicationFiled: December 19, 2014Publication date: November 17, 2016Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
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Publication number: 20160319018Abstract: The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The invention also relates to use of these antibodies in the treatment of dogs.Type: ApplicationFiled: December 19, 2014Publication date: November 3, 2016Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey, Leonard G. Presta
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Publication number: 20160311902Abstract: The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies againstcanine PD-1 that have a high binding affinity for canine PD-1. The invention further discloses the use of the caninized antibodies of the present invention in the treatment of cancer in dogs.Type: ApplicationFiled: December 19, 2014Publication date: October 27, 2016Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang, Ian Tarpey
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Patent number: 8784829Abstract: The present invention relates to polynucleotide sequences encoding novel Lawsonia intracellularis polypeptides. It also relates to DNA fragments, recombinant plasmid DNA and live recombinant microorganisms comprising these sequences. Moreover, the invention relates to polypeptides encoded by these nucleotide sequences. The invention also relates to immunogenic compositions for prevention of Lawsonia intracellularis infections and methods for the preparation of these immunogenic compositions. The invention also relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and detection of antibodies against Lawsonia intracellularis.Type: GrantFiled: October 21, 2009Date of Patent: July 22, 2014Assignee: Intervet Inc.Inventors: Mohamad A. Morsey, Stephanie M. Cook, Yuanzheng Zhang, Qing Zhang
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Publication number: 20110200631Abstract: The present invention relates to polynucleotide sequences encoding novel Lawsonia intracellularis polypeptides. It also relates to DNA fragments, recombinant plasmid DNA and live recombinant microorganisms comprising these sequences. Moreover, the invention relates to polypeptides encoded by these nucleotide sequences. The invention also relates to immunogenic compositions for prevention of Lawsonia intracellularis infections and methods for the preparation of these immunogenic compositions. The invention also relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and detection of antibodies against Lawsonia intracellularis.Type: ApplicationFiled: October 21, 2009Publication date: August 18, 2011Inventors: Mohamad A. Morsey, Yuanzheng Zhang, Qing Zhang, Stephanie M. Cook