Abstract: An isolation device includes an isolation chip, a pressing assembly, two ultrasonic generators, a differential pressure driving system, a frequency conversion module, and a controller. The isolation chip includes a sample reservoir, a first chamber, and a second chamber. The pressing assembly drives the two ultrasonic generators to move towards the isolation chip to make in contact with the first and second chambers. The frequency conversion module controls the differential pressure driving system to generate a negative pressure in the first and second chambers alternately. The controller controls the two ultrasonic generators to generate two ultrasonic waves when negative pressures are cancelled in the first and second chambers. An isolation method is also disclosed.

Abstract: A solar cell includes a semiconductor material having a dielectric layer over a light-receiving surface of the semiconductor material, a plurality of printed fire-through contacts passing substantially through the dielectric layer, each contact extending longitudinally in a first dimension, and a conductive finger extending longitudinally in a second dimension substantially perpendicular to the first dimension and electrically connecting the plurality of contacts to first and second busbars at opposite ends of the conductive finger. The conductive finger has at least one first portion overlaying and electrically connecting to the plurality of contacts, wherein each of the plurality of contacts extends beyond the first portion of the conductive finger at one or both sides of the first portion of the conductive finger in the first dimension, and wherein the first portion of the conductive finger overlays the dielectric.

Abstract: The present disclosure provides an automatic and portable system, comprising a bench-top instrument and a disposable microfluidic device for multiplex detection and quantitation of biomolecules such as proteins and nucleic acids from biological samples. The disposable device pre-encapsulates all the reagents including capture probes, detection probes, and wash buffer, with a waste reservoir in it, allowing all the liquids to be circulated inside the device, without interaction with the external environment. The bench-top instrument comprises a pressure control module and a fluorescence detection module, enabling automatic device operation and signal detection without manual intervention.

Abstract: The present disclosure provides a methodology for multimodal profiling of extracellular vesicles at single-particle resolution, including technique, workflow, and analytical algorithm.

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: Disclosed is an image sensor. The image sensor includes at least one photosensitive unit including at least two photosensitive layers stacked and not completely overlapped, a region where each photosensitive layer is not overlapped with other photosensitive layers being configured to arrange an electrode wire, and photosensitive component contents of the at least two photosensitive layers being different. According to the present disclosure, a wavelength range of sensible light of each photosensitive unit may be enlarged, so that more image details may be recorded, images with a high dynamic range may be generated, and people may experience a visual effect close to a real environment. In addition, as there is no need to reduce a photosensitive area of the photosensitive layer for arranging the electrode wires, the photosensitive area of the photosensitive layer is increased and thereby a dynamic range of the image sensor is improved.

Abstract: Disclosed is an image sensor, comprising: at least one photosensitive unit, where the photosensitive unit includes a main photosensitive region and an auxiliary photosensitive region arranged at the periphery of the main photosensitive region, and a photosensitive component content of the main photosensitive region is different from a photosensitive component content of the auxiliary photosensitive region. The disclosure enlarges a wavelength range of sensible light of each the photosensitive unit by arranging the auxiliary photosensitive region at the periphery of the main photosensitive region of the photosensitive unit, where the photosensitive component content of the main photosensitive region is different from that of the auxiliary photosensitive region. Thereby more image details may be recorded to generate images with high dynamic range, which enables people to experience a visual effect close to a real environment.

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: The present disclosure provides an automatic and portable system, comprising a bench-top instrument and a disposable microfluidic device for multiplex detection and quantitation of biomolecules such as proteins and nucleic acids from biological samples. The disposable device pre-encapsulates all the reagents including capture probes, detection probes, and wash buffer, with a waste reservoir in it, allowing all the liquids to be circulated inside the device, without interaction with the external environment. The bench-top instrument comprises a pressure control module and a fluorescence detection module, enabling automatic device operation and signal detection without manual intervention.

Abstract: An isolation chip for separating and isolating target particles from a bioliquid sample includes a reagent reservoir, a first filtration membrane, a second filtration membrane, a first chamber, and a second chamber. The reagent reservoir includes a first sidewall and a second sidewall opposite to the first sidewall. The first filtration membrane is disposed at an upper portion of the first sidewall. The reagent reservoir defines a first window at a lower portion of the first sidewall. The second filtration membrane is disposed at the second sidewall. The first chamber is connected to the reagent reservoir through the first filtration membrane. The second chamber is connected to the reagent reservoir through the second filtration membrane. A device and a method for detecting the target particles are further provided.

Abstract: The present disclosure provides a method for diagnosis based on proteins present on the surface of circulating extracellular vesicles. The method comprises incubating a sample of the subject with a detection antibody linked to a detectable label, contacting the sample with a capture antibody immobilized on a substrate, and detecting the detectable label on the circulating EV immobilized on the substrate. Compared to the method currently known in the art, the method disclosed herein has the advantages of high sensitivity with low cost and rapid procedure, high specificity.

Abstract: A method for fabricating memory device includes: providing a substrate having a bottom electrode layer therein, forming a buffer layer and a mask layer on the buffer layer over the substrate, in contact with the bottom electrode layer, performing an advanced oxidation process on a sidewall of the buffer layer to form a resistive layer, which surrounds the whole sidewall of the buffer layer and extends upward vertically from the substrate, and forming, over the substrate, a noble metal layer and a top electrode layer on the noble metal layer, fully covering the resistive layer and the mask layer.

Abstract: The disclosure relates to a battery lower casing and a battery system. The battery lower casing comprises: a support frame comprising a plurality of fixing beams that are connected end to end to form an accommodating space, wherein each of two fixing beams opposite to each other comprises a fixing portion extending toward the accommodating space, each of the fixing beams comprises fixing tabs at a side of the fixing beam away from the accommodating space, and the battery lower casing is connected to a target object through the fixing tabs; and a bottom plate connected to the fixing beams.

Abstract: An isolation chip assembly includes an isolation chip (10), first oscillators (20), and second oscillators (30). The isolation chip (10) includes a sample reservoir (13), a first filtration membrane (14) and a second filtration membrane (16) at opposite sides of the sample reservoir (13) . The first oscillators (20) are mounted on the first filtration membrane (14) and the second filtration membrane (16), and can generate a first oscillation wave when operating. The second oscillators (30) are mounted on outer surfaces of the first chamber (15) and the second chamber (17), and can generate a second oscillation wave when operating. A frequency of the first oscillation wave is greater than a frequency of the second oscillation wave, and an amplitude of the first oscillation wave is less than an amplitude of the second oscillation wave.

Abstract: Isochronous channels may be used for transporting non-isochronous data between components in an electronic device, such as when non-isochronous data is aggregated from multiple non-isochronous data streams to achieve a high peak-to-average bandwidth. The aggregated non-isochronous data sources may include data streams from general-purpose communications interfaces for interconnecting components or sub-systems of components within an electronic device. For example, I2C networks for control and programming of components may be connected to other I2C networks through an isochronous channel, such as a differential pair of Soundwire SWI3S wires.

Abstract: The present disclosure provides a microarray comprising a plurality of probes. Each probe comprises a first oligonucleotide and a second oligonucleotide. The location of each probe on the microarray can be determined by the length of the first oligonucleotide and the length of the second oligonucleotide, thus providing a spatially barcoded microarray. Also provided are the methods of producing such spatially barcoded microarray. Also provided are the method of using such spatially barcoded microarray.

Abstract: The present application provides a method and a system for integrating morphological characteristics and gene expression of individual cells. The method comprises the following steps: providing a microfluidic device, which comprises a microwell array and an interdigital electrode, and each microwell comprises a plurality of capture oligonucleotides; injecting cells into the microwells, capturing a single cell and recording morphological characteristics of the cell; lysing the cell so that the mRNA released by the cell is captured by the capture oligonucleotide; reverse transcribing the captured mRNA to obtain cDNA; performing a PCR amplification reaction on the cDNA to obtain a cDNA library and sequencing the cDNA library; reading the cell barcode sequence and the unique molecular identifier sequence according to sequencing results, and the morphological characteristics and gene expression of the cell in the microwell are integrated together.

Abstract: The present disclosure provides a microarray comprising a plurality of probes. Each probe comprises a first oligonucleotide and a second oligonucleotide. The location of each probe on the microarray can be determined by the length of the first oligonucleotide and the length of the second oligonucleotide, thus providing a spatially barcoded microarray. Also provided are the methods of producing such spatially barcoded microarray. Also provided are the method of using such spatially barcoded microarray.

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: A method for fabricating memory device includes: providing a substrate having a bottom electrode layer therein, forming a buffer layer and a mask layer on the buffer layer over the substrate, in contact with the bottom electrode layer, performing an advanced oxidation process on a sidewall of the buffer layer to form a resistive layer, which surrounds the whole sidewall of the buffer layer and extends upward vertically from the substrate, and forming, over the substrate, a noble metal layer and a top electrode layer on the noble metal layer, fully covering the resistive layer and the mask layer.