Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: The present disclosure provides methods and systems for separating one or more target analytes from a fluid sample. The systems may comprise a microfluidic device. The microfluidic device may comprise a fluidic channel having an array of obstacles disposed therein. The array of obstacles may be oriented at an angle greater than 0° relative to a direction of a fluid flow in the fluidic channel. The array of obstacles may be configured to separate the target analytes from the fluid upon flow of the fluid through the fluidic channel. The methods of the present disclosure may comprise separating target analytes from a fluid using a microfluidic device comprising obstacles disposed in a fluidic channel of the device. The target analytes may be separated with a high efficiency, sensitivity and/or specificity. Also disclosed herein are devices, methods, and systems for separating one or more biological particles from a fluid sample. The devices may comprise a substrate with a fluidic channel disposed therein.

Abstract: Disclosed is an image sensor. The image sensor includes at least one photosensitive unit including at least two photosensitive layers stacked and not completely overlapped, a region where each photosensitive layer is not overlapped with other photosensitive layers being configured to arrange an electrode wire, and photosensitive component contents of the at least two photosensitive layers being different. According to the present disclosure, a wavelength range of sensible light of each photosensitive unit may be enlarged, so that more image details may be recorded, images with a high dynamic range may be generated, and people may experience a visual effect close to a real environment. In addition, as there is no need to reduce a photosensitive area of the photosensitive layer for arranging the electrode wires, the photosensitive area of the photosensitive layer is increased and thereby a dynamic range of the image sensor is improved.

Abstract: The present disclosure provides a display panel, including: a display region, where the display region includes GaN-based LED units arranged in an array, the display region includes a first-selected region, the first-selected region includes a capturing-visible-light-image state including a state of real-time viewing before capturing and a capturing-image state; at the state of real-time viewing before capturing, some GaN-based LED units in the first-selected region are used for real-time viewing before capturing, and at the capturing-image state, all of the GaN-based LED units in the first-selected region are used for capturing an image.

Abstract: The present disclosure provides a method for diagnosis based on proteins present on the surface of circulating extracellular vesicles. The method comprises incubating a sample of the subject with a detection antibody linked to a detectable label, contacting the sample with a capture antibody immobilized on a substrate, and detecting the detectable label on the circulating EV immobilized on the substrate. Compared to the method currently known in the art, the method disclosed herein has the advantages of high sensitivity with low cost and rapid procedure, high specificity.

Abstract: The present disclosure provides a frontside-illuminated image sensor, including: a base, a photosensitive unit, a color filter unit and a lens structure. The base has charge storage regions. The photosensitive unit is on the base, the photosensitive unit includes photosensitive layers for different colors, and one of the photosensitive layers is electrically connected to one of the charge storage regions. The color filter unit is at a side of the photosensitive unit away from the base, the color filter unit includes color filter layers for different colors, and one of the color filter layers corresponds to one of the photosensitive layers. The lens structure is at a side of the color filter unit away from the base.

Abstract: The present disclosure provides a display panel, including a display region, where the display region includes at least a first region and a second region, and the first region and the second region include first GaN-based light emitting diode (LED) units arranged in an array; where the first region and the second region include a display state and an infrared recognition state; in the display state, the first GaN-based LED units in the first region and the second region are configured to display a visible light screen; in the infrared recognition state, the first GaN-based LED units in the first region are configured for emitting infrared light, and the first GaN-based LED units in the second region are configured for sensing infrared light.

Abstract: The present application provides a frontside-illuminated image sensor, including: a substrate, a photosensitive unit, and a lens structure. The substrate includes multiple charge storage regions. The photosensitive unit is on the substrate, where the photosensitive unit includes multiple photosensitive subunits, each of the multiple photosensitive subunits includes a red photosensitive layer, a green photosensitive layer, a blue photosensitive layer, and an infrared photosensitive layer) that are stacked, and the multiple photosensitive subunits are respectively electrically connected to the multiple charge storage regions. The lens structure is on a side of the photosensitive unit far from the substrate.

Abstract: The present application provides a frontside-illuminated image sensor, including a substrate, a photosensitive unit, and a lens structure. The substrate has a plurality of charge storage regions; The photosensitive unit is above the substrate, and the photosensitive unit includes a plurality of photosensitive sub-units. Each photosensitive sub-unit includes a red photosensitive layer, a green photosensitive layer, and a blue photosensitive layer that are stacked. One photosensitive sub-unit is electrically connected with one charge storage region; the lens structure is on a side of the photosensitive unit away from the substrate.

Abstract: An isolation device includes an isolation chip, a pressing assembly, two ultrasonic generators, a differential pressure driving system, a frequency conversion module, and a controller. The isolation chip includes a sample reservoir, a first chamber, and a second chamber. The pressing assembly drives the two ultrasonic generators to move towards the isolation chip to make in contact with the first and second chambers. The frequency conversion module controls the differential pressure driving system to generate a negative pressure in the first and second chambers alternately. The controller controls the two ultrasonic generators to generate two ultrasonic waves when negative pressures are cancelled in the first and second chambers. An isolation method is also disclosed.

Abstract: The present disclosure provides an automatic and portable system, comprising a bench-top instrument and a disposable microfluidic device for multiplex detection and quantitation of biomolecules such as proteins and nucleic acids from biological samples. The disposable device pre-encapsulates all the reagents including capture probes, detection probes, and wash buffer, with a waste reservoir in it, allowing all the liquids to be circulated inside the device, without interaction with the external environment. The bench-top instrument comprises a pressure control module and a fluorescence detection module, enabling automatic device operation and signal detection without manual intervention.

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: The present disclosure provides a methodology for multimodal profiling of extracellular vesicles at single-particle resolution, including technique, workflow, and analytical algorithm.

Abstract: Disclosed is an image sensor. The image sensor includes at least one photosensitive unit including at least two photosensitive layers stacked and not completely overlapped, a region where each photosensitive layer is not overlapped with other photosensitive layers being configured to arrange an electrode wire, and photosensitive component contents of the at least two photosensitive layers being different. According to the present disclosure, a wavelength range of sensible light of each photosensitive unit may be enlarged, so that more image details may be recorded, images with a high dynamic range may be generated, and people may experience a visual effect close to a real environment. In addition, as there is no need to reduce a photosensitive area of the photosensitive layer for arranging the electrode wires, the photosensitive area of the photosensitive layer is increased and thereby a dynamic range of the image sensor is improved.

Abstract: Disclosed is an image sensor, comprising: at least one photosensitive unit, where the photosensitive unit includes a main photosensitive region and an auxiliary photosensitive region arranged at the periphery of the main photosensitive region, and a photosensitive component content of the main photosensitive region is different from a photosensitive component content of the auxiliary photosensitive region. The disclosure enlarges a wavelength range of sensible light of each the photosensitive unit by arranging the auxiliary photosensitive region at the periphery of the main photosensitive region of the photosensitive unit, where the photosensitive component content of the main photosensitive region is different from that of the auxiliary photosensitive region. Thereby more image details may be recorded to generate images with high dynamic range, which enables people to experience a visual effect close to a real environment.

Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.

Abstract: The present disclosure provides an automatic and portable system, comprising a bench-top instrument and a disposable microfluidic device for multiplex detection and quantitation of biomolecules such as proteins and nucleic acids from biological samples. The disposable device pre-encapsulates all the reagents including capture probes, detection probes, and wash buffer, with a waste reservoir in it, allowing all the liquids to be circulated inside the device, without interaction with the external environment. The bench-top instrument comprises a pressure control module and a fluorescence detection module, enabling automatic device operation and signal detection without manual intervention.

Abstract: An isolation chip for separating and isolating target particles from a bioliquid sample includes a reagent reservoir, a first filtration membrane, a second filtration membrane, a first chamber, and a second chamber. The reagent reservoir includes a first sidewall and a second sidewall opposite to the first sidewall. The first filtration membrane is disposed at an upper portion of the first sidewall. The reagent reservoir defines a first window at a lower portion of the first sidewall. The second filtration membrane is disposed at the second sidewall. The first chamber is connected to the reagent reservoir through the first filtration membrane. The second chamber is connected to the reagent reservoir through the second filtration membrane. A device and a method for detecting the target particles are further provided.

Abstract: The present disclosure provides a method for diagnosis based on proteins present on the surface of circulating extracellular vesicles. The method comprises incubating a sample of the subject with a detection antibody linked to a detectable label, contacting the sample with a capture antibody immobilized on a substrate, and detecting the detectable label on the circulating EV immobilized on the substrate. Compared to the method currently known in the art, the method disclosed herein has the advantages of high sensitivity with low cost and rapid procedure, high specificity.

Abstract: A method for fabricating memory device includes: providing a substrate having a bottom electrode layer therein, forming a buffer layer and a mask layer on the buffer layer over the substrate, in contact with the bottom electrode layer, performing an advanced oxidation process on a sidewall of the buffer layer to form a resistive layer, which surrounds the whole sidewall of the buffer layer and extends upward vertically from the substrate, and forming, over the substrate, a noble metal layer and a top electrode layer on the noble metal layer, fully covering the resistive layer and the mask layer.