Patents by Inventor Yuchao CHEN

Yuchao CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220389411
    Abstract: The present application provides a method and a system for integrating morphological characteristics and gene expression of individual cells. The method comprises the following steps: providing a microfluidic device, which comprises a microwell array and an interdigital electrode, and each microwell comprises a plurality of capture oligonucleotides; injecting cells into the microwells, capturing a single cell and recording morphological characteristics of the cell; lysing the cell so that the mRNA released by the cell is captured by the capture oligonucleotide; reverse transcribing the captured mRNA to obtain cDNA; performing a PCR amplification reaction on the cDNA to obtain a cDNA library and sequencing the cDNA library; reading the cell barcode sequence and the unique molecular identifier sequence according to sequencing results, and the morphological characteristics and gene expression of the cell in the microwell are integrated together.
    Type: Application
    Filed: December 13, 2021
    Publication date: December 8, 2022
    Inventor: YUCHAO CHEN
  • Patent number: 11414696
    Abstract: The present disclosure provides a microarray comprising a plurality of probes. Each probe comprises a first oligonucleotide and a second oligonucleotide. The location of each probe on the microarray can be determined by the length of the first oligonucleotide and the length of the second oligonucleotide, thus providing a spatially barcoded microarray. Also provided are the methods of producing such spatially barcoded microarray. Also provided are the method of using such spatially barcoded microarray.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: August 16, 2022
    Assignee: WELLSIM BIOMEDICAL TECHNOLOGIES, INC.
    Inventor: Yuchao Chen
  • Publication number: 20220136938
    Abstract: An isolation device for isolation of target particles from a plurality of liquid samples includes a plurality of isolation chips and a vacuum system. Each of the plurality of isolation chips includes a sample reservoir, and a first outlet and a second outlet disposed at opposite sides of the sample reservoir. The vacuum system includes a first vacuum pump connected to the first outlet of each of the plurality of isolation chips and a second vacuum pump connected to the second outlet of each of the plurality of isolation chips. The first vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding first outlet. The second vacuum pump generates a negative pressure in each of the plurality of isolation chips through a corresponding second outlet. The target particles are isolated from each of the plurality of liquid samples in a corresponding sample reservoir.
    Type: Application
    Filed: January 14, 2022
    Publication date: May 5, 2022
    Inventor: YUCHAO CHEN
  • Publication number: 20220109104
    Abstract: A method for fabricating memory device includes: providing a substrate having a bottom electrode layer therein, forming a buffer layer and a mask layer on the buffer layer over the substrate, in contact with the bottom electrode layer, performing an advanced oxidation process on a sidewall of the buffer layer to form a resistive layer, which surrounds the whole sidewall of the buffer layer and extends upward vertically from the substrate, and forming, over the substrate, a noble metal layer and a top electrode layer on the noble metal layer, fully covering the resistive layer and the mask layer.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 7, 2022
    Applicant: United Microelectronics Corp.
    Inventors: Hai Tao Liu, Li Li Ding, Yao-Hung Liu, Guoan Du, Qi Lu Li, Chunlei Wan, Yi Yu Lin, Yuchao Chen, Huakai Li, Hung-Yueh Chen
  • Patent number: 11239419
    Abstract: The present invention relates to a structure of a memory device. The structure of a memory device includes a substrate, including a bottom electrode layer formed therein. A buffer layer is disposed on the substrate, in contact with the bottom electrode layer. A resistive layer surrounds a whole sidewall of the buffer layer, and extends upward vertically from the substrate. A mask layer is disposed on the buffer layer and the resistive layer. A noble metal layer is over the substrate, and fully covers the resistive layer and the mask layer. A top electrode layer is disposed on the noble metal layer.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: February 1, 2022
    Assignee: UNITED MICROELECTRONICS CORP.
    Inventors: Hai Tao Liu, Li Li Ding, Yao-Hung Liu, Guoan Du, Qi Lu Li, Chunlei Wan, Yi Yu Lin, Yuchao Chen, Huakai Li, Hung-Yueh Chen
  • Publication number: 20210359366
    Abstract: The disclosure relates to a battery lower casing and a battery system. The battery lower casing comprises: a support frame comprising a plurality of fixing beams that are connected end to end to form an accommodating space, wherein each of two fixing beams opposite to each other comprises a fixing portion extending toward the accommodating space, each of the fixing beams comprises fixing tabs at a side of the fixing beam away from the accommodating space, and the battery lower casing is connected to a target object through the fixing tabs; and a bottom plate connected to the fixing beams. The battery lower casing according to the disclosure carries weight of the battery module through the fixing portions of the support frame, and fixes the battery module to the vehicle through the fixing tabs. The bottom plate is only used to isolate the external environment. Therefore, the weight and manufacturing cost of the battery lower casing can be minimized.
    Type: Application
    Filed: July 11, 2019
    Publication date: November 18, 2021
    Applicants: Jiangsu Contemporary Amperex Technology Limited, Contemporary Amperex Technology Co., Limited
    Inventors: Yuchao CHEN, Xiaoshan DAI
  • Patent number: 11177527
    Abstract: The disclosure relates to a battery lower casing and a battery system. The battery lower casing includes: a bottom plate; a plurality of fixing beams sequentially connected end to end and fixed to the bottom plate; a cross beam disposed between the oppositely disposed fixing beams; and a supporting bracket including a base plate and limiting portions, wherein the limiting portions are connected to the base plate and disposed opposite to each other, the base plate and the oppositely disposed limiting portions enclose and form a recess, the base plate is connected to the fixing beam and an end portion of the cross beam adjacent to the fixing beam is embedded in the recess such that the cross beam is connected to the fixing beam.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: November 16, 2021
    Assignees: Jiangsu Contemporary Amperex Technology Limited, Contemporary Amperex Technology Co., Limited
    Inventor: Yuchao Chen
  • Publication number: 20210283552
    Abstract: An isolation chip for separating and isolating target particles from a bioliquid sample includes a reagent reservoir, a first filtration membrane, a second filtration membrane, a first chamber, and a second chamber. The reagent reservoir includes a first sidewall and a second sidewall opposite to the first sidewall. The first filtration membrane is disposed at an upper portion of the first sidewall. The reagent reservoir defines a first window at a lower portion of the first sidewall. The second filtration membrane is disposed at the second sidewall. The first chamber is connected to the reagent reservoir through the first filtration membrane. The second chamber is connected to the reagent reservoir through the second filtration membrane. A device and a method for detecting the target particles are further provided.
    Type: Application
    Filed: March 9, 2021
    Publication date: September 16, 2021
    Inventors: YUCHAO CHEN, FEI LIU
  • Publication number: 20210020877
    Abstract: The disclosure relates to a battery lower casing and a battery system. The battery lower casing includes: a bottom plate; a plurality of fixing beams sequentially connected end to end and fixed to the bottom plate; a cross beam disposed between the oppositely disposed fixing beams; and a supporting bracket including a base plate and limiting portions, wherein the limiting portions are connected to the base plate and disposed opposite to each other, the base plate and the oppositely disposed limiting portions enclose and form a recess, the base plate is connected to the fixing beam and an end portion of the cross beam adjacent to the fixing beam is embedded in the recess such that the cross beam is connected to the fixing beam.
    Type: Application
    Filed: August 27, 2019
    Publication date: January 21, 2021
    Applicants: Jiangsu Contemporary Amperex Technology Limited, Contemporary Amperex Technology Co., Limited
    Inventor: Yuchao CHEN
  • Publication number: 20210008553
    Abstract: The present disclosure provides methods and systems for separating one or more target analytes from a fluid sample. The systems may comprise a microfluidic device. The microfluidic device may comprise a fluidic channel having an array of obstacles disposed therein. The array of obstacles may be oriented at an angle greater than 0° relative to a direction of a fluid flow in the fluidic channel. The array of obstacles may be configured to separate the target analytes from the fluid upon flow of the fluid through the fluidic channel. The methods of the present disclosure may comprise separating target analytes from a fluid using a microfluidic device comprising obstacles disposed in a fluidic channel of the device. The target analytes may be separated with a high efficiency, sensitivity and/or specificity.
    Type: Application
    Filed: April 29, 2020
    Publication date: January 14, 2021
    Inventors: Daojing WANG, Yuchao CHEN, Pan MAO
  • Publication number: 20210005864
    Abstract: The present disclosure provides a connecting assembly and a battery pack, the connecting assembly comprises a busbar, a first insulating sleeve, a second insulating sleeve and a third insulating sleeve. The busbar comprises a main body portion, an extending portion, and a bent connection portion. The first insulating sleeve covers the main body portion. The second insulating sleeve covers the extending portion. The third insulating sleeve comprises a first covering portion, the first covering portion covers the bent connection portion. Because the first insulating sleeve, the second insulating sleeve and the third insulating sleeve are independent components, and they segmentally cover different parts of the busbar, so that each of them has a shorter length and less portion required to be bent, thereby facilitating the first insulating sleeve, the second insulating sleeve and the third insulating sleeve to be respectively sheathed on the different parts of the busbar.
    Type: Application
    Filed: August 26, 2019
    Publication date: January 7, 2021
    Inventors: Fan ZHANG, Xiaoshan DAI, Yuchao CHEN
  • Publication number: 20200388759
    Abstract: The present invention relates to a structure of a memory device. The structure of a memory device includes a substrate, including a bottom electrode layer formed therein. A buffer layer is disposed on the substrate, in contact with the bottom electrode layer. A resistive layer surrounds a whole sidewall of the buffer layer, and extends upward vertically from the substrate. A mask layer is disposed on the buffer layer and the resistive layer. A noble metal layer is over the substrate, and fully covers the resistive layer and the mask layer. A top electrode layer is disposed on the noble metal layer.
    Type: Application
    Filed: July 8, 2019
    Publication date: December 10, 2020
    Applicant: United Microelectronics Corp.
    Inventors: HAI TAO LIU, Li Li Ding, Yao-Hung Liu, Guoan Du, Qi Lu Li, Chunlei Wan, Yi Yu Lin, Yuchao Chen, Huakai Li, Hung-Yueh Chen
  • Publication number: 20200274130
    Abstract: The present disclosure provides a wire-bundle receiving bracket and a battery module. The wire-bundle receiving bracket is configured to fix a wire-bundle of the battery module and includes: a wire-bundle receiving slot including a first side wall and a second side wall opposite to the first side wall; a clasp part including a cover plate for covering the wire-bundle receiving slot, as well as a curved portion and a buckling portion that are disposed at two ends of the cover plate. The curved portion is connected to the first side wall, and the buckling portion is buckled on the second side wall. The present disclosure can facilitate the installing and receiving of the wire-bundle, thereby improving reliability of the received wire-bundle.
    Type: Application
    Filed: August 12, 2019
    Publication date: August 27, 2020
    Inventor: Yuchao Chen
  • Patent number: 10485749
    Abstract: A composition for treating a keratin material, comprising at least one amino acid surfactant, at least one amphoteric or zwitterionic surfactant, at least one solid fatty acid, at least one starch phosphates, and at least one acrylic thickening polymer. The composition has an improved rinsing speed after application, and is stable over 2 months, with an improved foaming properties, such as density of foam, and foaming volume.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: November 26, 2019
    Assignee: L'OREAL
    Inventors: Huifeng Wang, Yuchao Chen
  • Publication number: 20180333344
    Abstract: A composition for treating a keratin material, comprising at least one amino acid surfactant, at least one amphoteric or zwitterionic surfactant, at least one solid fatty acid, at least one starch phosphates, and at least one acrylic thickening polymer. The composition has an improved rinsing speed after application, and is stable over 2 months, with an improved foaming properties, such as density of foam, and foaming volume.
    Type: Application
    Filed: December 10, 2015
    Publication date: November 22, 2018
    Applicant: L'OREAL
    Inventors: Huifeng WANG, Yuchao CHEN
  • Patent number: 10052431
    Abstract: A sound manipulation system is provided. The sound manipulation system includes a flow chamber arranged and disposed to receive a fluid containing a particulate and provide in-line sound wave manipulation of at least a portion of the particulate from the fluid, and a transducer positioned to facilitate the in-line sound wave manipulation within the flow chamber. The flow chamber includes at least a first portion and a second portion, the first portion being self-aligned and secured to the second portion.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: August 21, 2018
    Assignee: Ascent Bio-Nano Technologies, Inc.
    Inventors: William Robert Dreschel, Yuchao Chen, Lin Wang
  • Publication number: 20170232439
    Abstract: An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided. Methods for separating cells or particles having different size, density and/or compressibility properties are also provided.
    Type: Application
    Filed: August 11, 2015
    Publication date: August 17, 2017
    Applicants: Carnegie Mellon University, Massachusetts Institute of Technology, The Penn State Research Foundation
    Inventors: Subra Suresh, Peng Li, Ming Dao, Yuchao Chen, Xiaoyun Ding, Tony Jun Huang, Zhangli Peng
  • Publication number: 20170106134
    Abstract: A sound manipulation system is provided. The sound manipulation system includes a flow chamber arranged and disposed to receive a fluid containing a particulate and provide in-line sound wave manipulation of at least a portion of the particulate from the fluid, and a transducer positioned to facilitate the in-line sound wave manipulation within the flow chamber. The flow chamber includes at least a first portion and a second portion, the first portion being self-aligned and secured to the second portion.
    Type: Application
    Filed: June 9, 2015
    Publication date: April 20, 2017
    Applicant: Ascent Bio-Nano Technologies, Inc.
    Inventors: William Robert Dreschel, Yuchao Chen, Lin Wang
  • Publication number: 20150104845
    Abstract: An acoustic manipulation process and acoustic manipulation device are disclosed. The acoustic manipulation process includes providing a device having a pathway positioned to receive a flow of a particle-containing fluid, transporting the particle-containing fluid into the pathway, and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway. The applying of the standing surface acoustic waves to the particle-containing fluid includes nodes and anti-nodes of the standing surface acoustic waves extending through the particle-containing fluid. The acoustic manipulation device includes a pathway positioned to receive a flow of a particle-containing fluid, and a mechanism for generating and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 16, 2015
    Inventors: Tony Jun HUANG, Yuchao CHEN