Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) ligand (PD-L1) and inhibit PD-L1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD-L1-mediated functions.

Abstract: A contact assembly is for a vacuum switching apparatus. The vacuum switching apparatus includes a vacuum envelope. The vacuum envelope has an interior. The contact assembly includes: a number of electrical contacts located in the interior of the vacuum envelope, at least one electrical contact having a hole; and a number of electrodes each engaging a corresponding one of the number of electrical contacts, at least one electrode including a base and a protrusion. The protrusion extends from the base into the hole of the electrical contact in order to secure the electrical contact to the electrode.

Abstract: A vacuum interrupter assembly is provided. The vacuum interrupter assembly includes an operating mechanism, a vacuum chamber including a number of bellows assemblies, a conductor assembly including a first contact assembly and a second contact assembly, the first contact assembly including a stem and a contact member, the first contact assembly stem including an elongated body with a proximal first end, a medial portion, and a distal second end. The first contact assembly stem body has a reduced length. The first contact assembly stem body having a reduced length generates less heat and electrical resistance.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) ligand (PD-L1) and inhibit PD-L1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD-L1-mediated functions.

Abstract: A vacuum interrupter assembly is provided. The vacuum interrupter assembly includes an operating mechanism, a vacuum chamber including a number of bellows assemblies, a conductor assembly including a first contact assembly and a second contact assembly, the first contact assembly including a stem and a contact member, the first contact assembly stem including an elongated body with a proximal first end, a medial portion, and a distal second end. The first contact assembly stem body has a reduced length. The first contact assembly stem body having a reduced length generates less heat and electrical resistance.

Abstract: A vacuum interrupter assembly is provided. The vacuum interrupter assembly includes an operating mechanism, a vacuum chamber including a number of bellows assemblies, a conductor assembly including a first contact assembly and a second contact assembly, the first contact assembly including a stem and a contact member, the first contact assembly stem including an elongated body with a proximal first end, a medial portion, and a distal second end. The first contact assembly stem body has a reduced length. The first contact assembly stem body having a reduced length generates less heat and electrical resistance.

Abstract: A vacuum interrupter assembly is provided. The vacuum interrupter assembly includes an operating mechanism, a vacuum chamber including a number of bellows assemblies, a conductor assembly including a first contact assembly and a second contact assembly, the first contact assembly including a stem and a contact member, the first contact assembly stem including an elongated body with a proximal first end, a medial portion, and a distal second end. The first contact assembly stem body has a reduced length. The first contact assembly stem body having a reduced length generates less heat and electrical resistance.

Abstract: A contact assembly is for a vacuum switching apparatus. The vacuum switching apparatus includes a vacuum envelope. The vacuum envelope has an interior. The contact assembly includes: a number of electrical contacts located in the interior of the vacuum envelope, at least one electrical contact having a hole; and a number of electrodes each engaging a corresponding one of the number of electrical contacts, at least one electrode including a base and a protrusion. The protrusion extends from the base into the hole of the electrical contact in order to secure the electrical contact to the electrode.

Abstract: A contact assembly is for a vacuum switching apparatus. The vacuum switching apparatus includes a vacuum envelope. The vacuum envelope has an interior. The contact assembly includes: a number of electrical contacts located in the interior of the vacuum envelope, at least one electrical contact having a hole; and a number of electrodes each engaging a corresponding one of the number of electrical contacts, at least one electrode including a base and a protrusion. The protrusion extends from the base into the hole of the electrical contact in order to secure the electrical contact to the electrode.

Abstract: The present invention discloses a combination unit and method of multiple membrane shells. The combination unit of multiple membrane shells is formed by bundling multiple membrane shells in parallel, wherein the raw water port and the concentrated water port of each of the membrane shells are respectively connected and sealed with the raw water port and the concentrated water port of the adjacent membrane shells to form the shared raw water port and the shared concentrated water port which are respectively connected with the raw water pipeline and the concentrated water pipeline. Since each of the combination units of multiple membrane shells is provided with the shared raw water port and the shared concentrated water port, it is adequate to finish the assembly of the shared raw water port with the pipeline and the assembly of the shared concentrated water port with the pipeline in the engineering installation. The combination unit of multiple membrane shells can be placed horizontally or vertically.

Abstract: A retaining clip is for a vacuum interrupter. The vacuum interrupter includes a tubular ceramic member, a tubular shield member, and a pair of separable contacts. The shield member is disposed internal with respect to the ceramic member. The separable contacts are disposed internal with respect to the shield member. The retaining clip comprises: a base mounted on the ceramic member; and at least one flexible arm extending from the base. The flexible arm engages the shield member in order to retain the shield member on the ceramic member.

Abstract: A retaining clip is for a vacuum interrupter. The vacuum interrupter includes a tubular ceramic member, a tubular shield member, and a pair of separable contacts. The shield member is disposed internal with respect to the ceramic member. The separable contacts are disposed internal with respect to the shield member. The retaining clip comprises: a base mounted on the ceramic member; and at least one flexible arm extending from the base. The flexible arm engages the shield member in order to retain the shield member on the ceramic member.

Abstract: A contact assembly is for a vacuum switching apparatus. The vacuum switching apparatus includes a vacuum envelope. The vacuum envelope has an interior. The contact assembly includes: a number of electrical contacts located in the interior of the vacuum envelope, at least one electrical contact having a hole; and a number of electrodes each engaging a corresponding one of the number of electrical contacts, at least one electrode including a base and a protrusion. The protrusion extends from the base into the hole of the electrical contact in order to secure the electrical contact to the electrode.

Abstract: An electrode extension assembly is for a vacuum switching apparatus, such as a vacuum interrupter, including a vacuum envelope and separable contact assemblies. Each contact assembly includes a contact disposed in the interior of the vacuum envelope, and an electrode stem extending outwardly from the contact to the exterior of the vacuum envelope. The electrode extension assembly includes a number of extension members each being be joined to the electrode stem of a corresponding one of the contact assemblies on the exterior of the vacuum envelope by a welded joint formed by electron beam welding or plasma welding.

Abstract: An electrode extension assembly is for a vacuum switching apparatus, such as a vacuum interrupter, including a vacuum envelope and separable contact assemblies. Each contact assembly includes a contact disposed in the interior of the vacuum envelope, and an electrode stem extending outwardly from the contact to the exterior of the vacuum envelope. The electrode extension assembly includes a number of extension members each being be joined to the electrode stem of a corresponding one of the contact assemblies on the exterior of the vacuum envelope by a welded joint formed by electron beam welding or plasma welding.

Abstract: The present invention discloses a combination unit and method of multiple membrane shells. The combination unit of multiple membrane shells is formed by bundling multiple membrane shells in parallel, wherein the raw water port and the concentrated water port of each of the membrane shells are respectively connected and sealed with the raw water port and the concentrated water port of the adjacent membrane shells to form the shared raw water port and the shared concentrated water port which are respectively connected with the raw water pipeline and the concentrated water pipeline. Since each of the combination units of multiple membrane shells is provided with the shared raw water port and the shared concentrated water port, it is adequate to finish the assembly of the shared raw water port with the pipeline and the assembly of the shared concentrated water port with the pipeline in the engineering installation. The combination unit of multiple membrane shells can be placed horizontally or vertically.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.