Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.

Abstract: Provided are an all-solid-state battery and a preparation method thereof. The all-solid-state battery includes a positive electrode, a negative electrode, and a solid-state electrolyte located between the positive electrode and the negative electrode. The negative electrode includes a first negative electrode and a second negative electrode. The second negative electrode is located on a side of the first negative electrode. The solid-state electrolyte includes a first solid-state electrolyte and a second solid-state electrolyte. The first solid-state electrolyte is located between the positive electrode and the first negative electrode. The second solid-state electrolyte is located between the positive electrode and the second negative electrode. The roughness of the second solid-state electrolyte is greater than the roughness of the first solid-state electrolyte.

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

Abstract: Embodiments of this application provide a data transmission method, a multi-function card, and an electronic device. The multi-function card may work as a SIM card or a memory card by using electrical contacts through time division multiplexing. Data is transmitted between the multi-function card and a processor in the electronic device, so that a function of subscriber identity identification can be implemented, and a storage capacity of the electronic device can be expanded. Storage space expanded in the electronic device may be used to store a picture, audio, a video, and an application program. The data transmission method and the multi-function card provided in embodiments of this application may be used to save physical space in the electronic device. This is conducive to lightening and thinning of the electronic device.

Abstract: The present invention relates to a high-toughness geopolymer grouting material modified by ultra-high molecular weight fibers and emulsified asphalt, and a preparation method and application thereof, wherein the grouting material comprises the following components in parts by mass: 4-12 parts of emulsified asphalt, 80-100 parts of a geopolymer, 103-126 parts of an alkali-activated solution, 2-3 parts of ultra-high molecular weight fibers and 30-35 parts of water. Compared to the prior art, the grouting material modified by ultra-high molecular weight fibers and emulsified asphalt is simple to prepare, has good fluiditygood, and matches well with road substrate; the good toughness and crack control capability of the ultra-high molecular weight fibers enables this novel grouting material to overcome the problem in durability of common geopolymer-based materials.

Abstract: A sealed feeder device utilized in an electric arc furnace (1), and a flue gas and temperature control method. The sealed feeder device comprises a sealed feeding chute (5) having an outlet sealedly communicating with a side wall of the electric arc furnace (1), and a material blocking sealed arc-shaped door (3) disposed in the sealed feeding chute (5). The material blocking sealed arc-shaped door (3) separates the sealed feeding chute (5) into a cold steel scrap storage chamber (18) and a material feeding and dedusting chamber (2), and is operated by a driving mechanism (34) to separate or connect the cold steel scrap storage chamber (18) and the material feeding and dedusting chamber (2).

Abstract: An electrode assembly for endoscopic surgery, including an electrode core wire (1), a telescopic control member (2) and an insulating outer sleeve (3). The electrode core wire (1) includes an electrode tip (101), a coaxial cable (102) and an electrode insulating tube (103). The electrode tip (101) is electrically coupled to an output end of an external host through the coaxial cable (102). The electrode insulating tube (103) sleeves on the electrode tip (101). The insulating outer sleeve (3) movably sleeves on the outside of the electrode core wire (1), and one end of the insulating outer sleeve (3) where the electrode tip (101) is located is a preset distance longer than the electrode insulating tube (103). The telescopic control member (2) is configured to control the movement of the insulating outer sleeve (3) so that the electrode tip 101 extends out of the insulating outer sleeve (3) or retracts into the insulating outer sleeve (3).

Abstract: The present invention belongs to the technical field of metallurgy, and discloses a horizontal continuous feeding preheating device and an enhanced preheating method therefor. The scheme comprises that two dust removal ports are arranged at the front and rear parts of a horizontal continuous feeding preheating duct, and the horizontal continuous feeding preheating duct is divided into an enhanced preheating area and a flue gas preheating area by the two dust removal ports arranged at the front and rear parts of the horizontal continuous feeding preheating duct; burners are installed in the enhanced preheating area, and the two dust removal ports are connected with a flue gas adjusting distributor respectively by a flue gas pipeline the steel scrap preheating efficiency of the burners and electric arc furnace flue gas is increased by controlling the flow rate and temperature of mixed flue gas.

Abstract: A Lidar system, window of the Lidar system and a method of moving a fluid along a window. The window includes a first electrode disposed on a first side of a outermost layer of the window, a second electrode disposed on the first side of the outermost layer, and a processor. The processor is configured to activate the first electrode to draw a fluid to a first location on a second side of the outermost layer opposite the first electrode, deactivate the first electrode, and activate the second electrode to draw the fluid to a second location on the second side of the outermost layer opposite the second electrode.

Abstract: A method for predicting and optimizing an ROP for oil and gas drilling based on Bayesian optimization includes: acquiring raw drilling data according to a preset sampling period, constructing an initial sample data set based on the raw drilling data, constructing an ROP prediction model based on the initial sample data set, and predicting an ROP at a next sample point through a Gaussian process regression based on the ROP prediction model. The present invention realizes rapid analysis of historical drilling data and accurate prediction of an ROP range at a sample point in a feasible domain. The method can obtain an optimized ROP and an optimized engineering parameter through Bayesian optimization, and obtain an engineering parameter corresponding to an optimal ROP. The method has few restrictions on the drilling engineering parameter and the raw formation parameter, improves prediction accuracy, and avoids the problem of blurred parameter value boundaries.

Abstract: A bag-making and packaging apparatus includes a bag-making and packaging unit, a film feeding unit, a splicing device, and a control unit. The control unit allows a bag-making operation to continue by utilizing an auto-feeding function that feeds to the bag-making and packaging unit a film F spliced by the splicing device to take the place of a film F currently being fed to the bag-making and packaging unit. When the control unit judges that at least one of the film feeding unit and the splicing device is malfunctioning in a case where the control unit is utilizing the auto-feeding function, the control unit stops the auto-feeding function and executes a non-auto-feeding mode. The non-auto-feeding mode allows the bag-making operation to be continued by the bag-making and packaging unit and a film roll holding unit that is operable among plural film roll holding units.

Abstract: A method for predicting and optimizing an ROP for oil and gas drilling based on Bayesian optimization includes: acquiring raw drilling data according to a preset sampling period, constructing an initial sample data set based on the raw drilling data, constructing an ROP prediction model based on the initial sample data set, and predicting an ROP at a next sample point through a Gaussian process regression based on the ROP prediction model. The present invention realizes rapid analysis of historical drilling data and accurate prediction of an ROP range at a sample point in a feasible domain. The method can obtain an optimized ROP and an optimized engineering parameter through Bayesian optimization, and obtain an engineering parameter corresponding to an optimal ROP. The method has few restrictions on the drilling engineering parameter and the raw formation parameter, improves prediction accuracy, and avoids the problem of blurred parameter value boundaries.

Abstract: An antenna structure includes: a branching radiator, including a plurality of first radiation modes; a ring-shaped radiator surrounding the branching radiator, and including a plurality of second radiation modes; a feeding point and a grounding point, one of which is connected to the ring-shaped radiator, and the other is connected to the branching radiator; an antenna gap, which is provided between the branching radiator and the ring-shaped radiator. The ring-shaped radiator and the branching radiator are coupled through the antenna gap to form coupled radiation modes. A coupling among the first radiation modes, the second radiation modes and the coupled radiation modes broaden a radiation bandwidth of the antenna structure. The antenna structure may be incorporated in an electronic device.

Abstract: Provided is a monocyclic ?-lactam compound as shown in general formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof. Also provided are a pharmaceutical composition containing the monocyclic ?-lactam compound as shown in general formula (I), or an ester, a stereoisomer or a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug for treating bacterial infections.

Abstract: A heterocyclic compound, and a pharmaceutical composition thereof, a preparation method therefor, an intermediate thereof and an application thereof. The structure of the heterocyclic compound is as shown in formula (I) below. The compound has CDK7 inhibitory activity, and can be used to treat tumors and other diseases.

Abstract: A compound with the structure of formula I or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug, or isotope label thereof: the KRAS G12C inhibitor compound has a good inhibitory effect on KRAS mutations, and can be used for the prevention and/or treatment of KRAS G12C-mediated diseases.

Abstract: Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX).