Abstract: The present invention relates to a high-toughness geopolymer grouting material modified by ultra-high molecular weight fibers and emulsified asphalt, and a preparation method and application thereof, wherein the grouting material comprises the following components in parts by mass: 4-12 parts of emulsified asphalt, 80-100 parts of a geopolymer, 103-126 parts of an alkali-activated solution, 2-3 parts of ultra-high molecular weight fibers and 30-35 parts of water. Compared to the prior art, the grouting material modified by ultra-high molecular weight fibers and emulsified asphalt is simple to prepare, has good fluiditygood, and matches well with road substrate; the good toughness and crack control capability of the ultra-high molecular weight fibers enables this novel grouting material to overcome the problem in durability of common geopolymer-based materials.

Abstract: Provided are a class of benzimidazole compounds and an application thereof as a 300/CBP inhibitor. Specifically, provided are a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to a method for predicting an amount of water-sealed gas in a high-sulfur water-bearing gas reservoir. The method solves the problem that no method has yet been proposed for predicting the amount of water-sealed gas in a high-sulfur water-bearing gas reservoir. According to the technical solution, the method includes: considering that the volume of the gas reservoir does not change during the production of the constant-volume gas reservoir, deriving, based on a material balance method, a material balance equation of the high-sulfur water-bearing gas reservoir in consideration of water-sealed gas and water-soluble gas, solving and drawing a chart of water-sealed gas in the high-sulfur water-bearing gas reservoir by an iterative algorithm, obtaining a recovery factor of the high-sulfur water-bearing gas reservoir in consideration of water-sealed gas and water-soluble gas, and further obtaining the amount of water-seal gas in the high-sulfur water-bearing gas reservoir.

Abstract: Compounds having both BET bromodomain protein inhibitory activity and PD-L1 gene expression regulation, and use thereof in preparing medicaments for treating tumor diseases related to BET bromodomain protein inhibition and PD-L1 gene expression. Specifically disclosed are a compound as shown in formula (1), and an isomer and a pharmaceutically acceptable salt thereof.