Abstract: Nucleic acid molecules and single-domain antibody applications are provided. The nucleic acid molecules include a transgenic host animal immunoglobulin genes or parts of immunoglobulin genes. Main characters are: it comprises the transgenic host animal IgH 5?-enhancer, IgM switch region (S?), and IgM sequences, specifically, all the IgM sequences are originated from the transgenic host animal, and the CH1 sequences of the IgM is deleted (IgM-dCH1). The regulatory control sequences of IgG are also derived from the transgenic host animal including S?, TM1, TM2, PolyA sequences, etc., and IgG C? sequences (Hinge, CH2 and CH3) are human sequence (Ig?-dCH1). The present invention ensures normal B-cell development in transgenic animal, and the transgenic animal expresses human single-domain antibodies, reducing the subsequent antibody humanization process and improving the druggability of the antibodies.

Abstract: Nucleic acid molecules include immunoglobulin genes or parts of immunoglobulin genes. The nucleic acid molecules includes the IgM gene (IgHC?) and IgM switch region (S?). The sequences of the S? and the IgHC? are both derived from a transgenic host animal. In this invention, human antibodies are directly generated and no humanization process is required, and the human antibody druggability is increased. The transgenic human antibody mouse has normal early B?cell development, maturation and the B?cell number in comparison with that of wild type animal, thereby facilitating the differentiation of the B?cells. The specificity and diversity of the produced antibody are improved; and the efficiency for screening the therapeutic antibody is improved.

Abstract: A smart electronic device is provided for a multi-user environment to meet more convenient life requirements of a plurality of users. The smart electronic device has a camera, a microphone, a processing circuit, a network interface and a projector. The processing circuit loads a user's image and determines an identity of the user appearing before the camera based on the user's image. The processing circuit also analyzes a gesture of the user fetched by the camera or a voice message fetched by the microphone for transforming into a corresponding operating command. The projector displays a frame generated in correspondence to the operating command.

Abstract: This disclosure provides a method, system for associating a target object with an item and a non-transitory computer-readable recording medium, and relates to the field of intelligent monitoring technology. The method is applied to a processing device, and the processing device is connected to a laser radar mounted on a rack; the method includes: acquiring sensing information obtained from that the laser radar senses the target object; determining a trigger point coordinate of the target object within the sensing range according to the sensing information; and determining an item associated with the target object according to the trigger point coordinate of the target object and a position coordinate of said each item stored in advance. This disclosure can be widely applied to many types of racks, suitable for a variety of monitoring occasions.

Abstract: This disclosure provides an automatic billing system and an automatic billing method, and relates to the field of intelligent billing technologies, the automatic billing method is executed by a billing terminal, the method includes: receiving physical information of the items to be checked out acquired by the physical information acquiring device, the physical information including weight and/or volume; receiving image information of the items to be checked out acquired by the image acquiring device; determining identity information of the items to be checked out according to the image information of the items to be checked out; verifying whether the identity information of the items to be checked out is correct according to the physical information of the items to be checked out; and if correct, proceeding to checkout of the items to be checked out.

Abstract: An IOT (Internet Of Things) terminal apparatus, to be able to work with other IOT devices, includes following elements. A communication circuit communicates with at least one external IOT device through a communication network. A timing module time times through the internal timing module to produce a present estimated time, and according to a predetermined rule, to obtain a time proof information from external IOT devices through the communication circuit. After obtaining the time proof information, judges whether to adjust the present estimated time calculated by the internal timing module or not, according to the predetermined rule. A processing circuit cooperates with the external IOT devices, according to the present estimation time, to complete a predetermined IOT operation.

Abstract: A smart electronic device is provided for a multi-user environment to meet more convenient life requirements of a plurality of users. The smart electronic device has a camera, a microphone, a processing circuit, a network interface and a projector. The processing circuit loads a user's image and determines an identity of the user appearing before the camera based on the user's image. The processing circuit also analyzes a gesture of the user fetched by the camera or a voice message fetched by the microphone for transforming into a corresponding operating command. The projector displays a frame generated in correspondence to the operating command.