Patents by Inventor Yue-Jen Chuu

Yue-Jen Chuu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for determining fraction of fetal nucleic acids in maternal samples
    Patent number: 12139760
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: November 12, 2024
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20210054458
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: June 11, 2020
    Publication date: February 25, 2021
    Inventors: Yue-Jen CHUU, Richard P. RAVA
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20200385810
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: April 3, 2020
    Publication date: December 10, 2020
    Applicant: Verinata Health, Inc.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • Methods of fetal abnormality detection
    Patent number: 10718020
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: July 21, 2020
    Assignee: Verinata Health, Inc.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • Methods for determining fraction of fetal nucleic acids in maternal samples
    Patent number: 10612096
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 7, 2020
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20170073757
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 16, 2017
    Inventors: Yue-Jen CHUU, Richard P. RAVA
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20170037474
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Applicant: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • Methods of fetal abnormality detection
    Patent number: 9493831
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: November 15, 2016
    Assignee: VERINATA HEALTH, INC.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • Methods for determining fraction of fetal nucleic acids in maternal samples
    Patent number: 9493828
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: November 15, 2016
    Assignee: VERINATA HEALTH, INC.
    Inventors: Richard P. Rava, Yue-Jen Chuu, Manjula Chinnappa, David A. Comstock, Gabrielle Heilek, Michael Hunkapiller
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20150218631
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: April 2, 2015
    Publication date: August 6, 2015
    Inventors: Yue-Jen CHUU, Richard P. RAVA
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20140199691
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 17, 2014
    Applicant: Verinata Health, Inc.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • Methods of fetal abnormality detection
    Patent number: 8318430
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: November 27, 2012
    Assignee: Verinata Health, Inc.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20120214678
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: May 1, 2012
    Publication date: August 23, 2012
    Applicant: VERINATA HEALTH, INC.
    Inventors: RICHARD P. RAVA, YUE-JEN CHUU, MANJULA CHINNAPPA, DAVID A. COMSTOCK, GABRIELLE HEILEK, MICHAEL HUNKAPILLER
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20120135872
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: February 7, 2012
    Publication date: May 31, 2012
    Applicant: Verinata Health, Inc.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • METHODS FOR DETERMINING FRACTION OF FETAL NUCLEIC ACIDS IN MATERNAL SAMPLES
    Publication number: 20120010085
    Abstract: The invention provides compositions and methods for determining the fraction of fetal nucleic acids in a maternal sample comprising a mixture of fetal and maternal nucleic acids. The fraction of fetal nucleic acids can be used in determining the presence or absence of fetal aneuploidy.
    Type: Application
    Filed: December 1, 2010
    Publication date: January 12, 2012
    Inventors: Richard P. RAVA, Yue-Jen CHUU, Manjula CHINNAPPA, David A. COMSTOCK, Gabrielle HEILEK, Michael HUNKAPILLER
  • METHODS OF FETAL ABNORMALITY DETECTION
    Publication number: 20110312503
    Abstract: Methods and kits for selectively enriching non-random polynucleotide sequences are provided. Methods and kits for generating libraries of sequences are provided. Methods of using selectively enriched non-random polynucleotide sequences for detection of fetal aneuploidy are provided.
    Type: Application
    Filed: January 24, 2011
    Publication date: December 22, 2011
    Applicant: Artemis Health, Inc.
    Inventors: Yue-Jen Chuu, Richard P. Rava
  • Methods and compositions for identifying a fetal cell
    Publication number: 20100304978
    Abstract: The present invention provides methods and compositions for specifically identifying a fetal cell. An initial screening of approximately 400 candidate genes by digital PCR in different fetal and adult tissues identified a subset of 24 gene markers specific for fetal nucleated RBC and trophoblasts. The specific expression of those genes was further evaluated and verified in more defined tissues and isolated cells through quantitative RT-PCR using custom Taqman probes specific for each gene. A subset of fetal cell specific markers (FCM) was tested and validated by RNA fluorescent in situ hybridization (FISH) in blood samples from non-pregnant women, and pre-termination and post-termination pregnant women.
    Type: Application
    Filed: January 26, 2010
    Publication date: December 2, 2010
    Inventors: David Xingfei Deng, Yun Bao, Yue-Jen Chuu, Daniel Shoemaker, David L. Robbins