Patents by Inventor Yue Jiang

Yue Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250022532
    Abstract: A method of modeling enhancer activity obtains a training dataset in electronic form. The dataset comprises a plurality of training enhancers and, for each such enhancer, a corresponding measured amount of activity of the enhancer in each of one or more states. Each enhancer is a tandem repeat. A model comprising a plurality of parameters is trained by inputting each training enhancer into the model. Upon input, the model applies the parameters to the training enhancer to generate, as model output, a corresponding predicted activity of the training enhancer for a first state of the one or more states. The plurality of parameters is refined based differentials between corresponding measured and predicted amounts of activity in the first state for each of the training enhancer. A plurality of test enhancers is generated using the trained model and their activity tested thereby modeling enhancer activity.
    Type: Application
    Filed: June 28, 2024
    Publication date: January 16, 2025
    Inventors: Yue Jiang, Ronald James Hause, JR., Timothy George Johnstone, Jacob Michael Tome
  • Publication number: 20250014676
    Abstract: Systems and methods for generating a polymer sequence for a biological molecule having one or more target biological properties are provided. A plurality of target metric values for one or more target biological properties of a biological molecule and a seed for a nucleic acid or amino acid sequence for the biological molecule are inputted into a conditional generator model of a conditional generative adversarial network to obtain as output from the conditional generator model a nucleic acid or amino acid sequence for the biological molecule that is predicted by the conditional generator model to confer on the biological molecule the one or more target biological properties approximating the plurality of target metric values.
    Type: Application
    Filed: March 15, 2024
    Publication date: January 9, 2025
    Inventors: Bora Srecko Banjanin, Ronald James Hause, JR., Yue Jiang, Brian Booth, Yiannis Savva, Lina Rajili Bagepalli, Kevin Christopher Stein, Adrian Wrangham Briggs, Thomas Alexander Packard
  • Patent number: 12118780
    Abstract: The present disclosure relates to a PointEFF method for urban object classification with LiDAR point cloud data, and belongs to the field of LiDAR point cloud classification. The method comprises: point cloud data segmentation; End-to-end feature extraction layer construction; External feature fusion layer construction; and precision evaluation.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: October 15, 2024
    Assignee: GUILIN UNIVERSITY OF TECHNOLOGY
    Inventors: Guoqing Zhou, Yue Jiang, Haoyu Wang
  • Publication number: 20240272134
    Abstract: A suspended self-balancing self-cruising online water quality monitoring device, an online water quality monitoring method, and an online water quality assessment method are provided. The device includes a suspension cabin main body, a communication and control system, and a suspended carrying platform configured for self-balancing attitude adjustment. Suspension feet configured to drive the suspension cabin main body to implement self-balancing attitude adjustment, cruising, or fixed-point suspension are arranged outside the suspension cabin main body. The communication and control system is configured to plan a W-shaped water-region cruising path and sampling points thereon according to a topography of a water region, control the water sample testing device to test quality of water along the sampling points online, assess water quality of the water region according to an online testing result, and output the water quality of the water region.
    Type: Application
    Filed: February 10, 2022
    Publication date: August 15, 2024
    Applicant: JIANGSU UNIVERSITY
    Inventors: Yue JIANG, You TANG, Hong LI, Lin HUA, Jialing LIU
  • Patent number: 12049667
    Abstract: Provided herein are methods for target gene sequencing and single cell barcoding in conjunction with analysis of gene expression in single cells. In some embodiments, the target gene is an immune molecule, such as an antibody or TCR. In some embodiments, the methods can be used to carry out transcriptome sequencing, e.g., RNA sequencing, to capture transcriptome of single cells paired with full receptor immune receptor sequences such that information about the immune repertoire and transcriptome of a cell can be determined. Also provided are polynucleotide libraries for use in carrying out transcriptome analysis and immune molecule, e.g., antibody or TCR, sequencing.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 30, 2024
    Assignee: ABvitro LLC
    Inventors: Stephen Jacob Goldfless, Adrian Wrangham Briggs, Rajagopal Chari, Yue Jiang, Ronald Hause, Francois Vigneault
  • Publication number: 20240226298
    Abstract: Provided are B cell-activating factor receptor (BAFF-R)-binding molecules, in particular, to human antibodies specific for BAFF-R, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for BAFF-R. Also provided are CARs which contain extracellular binding domains that bind to BAFF-R and B-lymphocyte antigen CD19 (CD19), genetically engineered cells expressing such CARs, and uses thereof in adoptive cell therapy.
    Type: Application
    Filed: December 12, 2023
    Publication date: July 11, 2024
    Applicant: Juno Therapeutics, Inc.
    Inventors: Ruth Amanda SALMON, Douglas JONES, Brian BELMONT, Madeline WILLIAMS, Rebekah TURK, Eric William JEFFERY, Andres ALVAREZ, Yue JIANG, Gabriela DIAZ, Thomas COX, Chia-Yung WU, Tiffany HUELAR, Jon JONES, Stephanie BUSCH, Cedric CLEYRAT
  • Patent number: 12032997
    Abstract: Techniques are described herein that are capable of reducing interrupts using buffering for data processing. In a first example, information is received at an operating system from an application. The information indicates multiple buffers, including a triggering buffer to trigger an interrupt from hardware. Portions of the data are stored in the respective buffers. A schedule for processing the buffers is provided to the hardware. The schedule indicates that the interrupt is to be delayed until the triggering buffer is processed by the hardware. In a second example, a network interface controller is configured to provide one interrupt to the operating system for each of multiple subsets of network packets that is processed by the network interface controller. Each subset includes a number of the network packets that is greater than one. The network packets are associated with a common network socket.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: July 9, 2024
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Glenn F. Evans, Yue Jiang
  • Patent number: 11952408
    Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 9, 2024
    Assignees: Juno Therapeutics, Inc., Editas Medicine, Inc.
    Inventors: Cameron Brandt, Brian Belmont, Christopher Borges, Stephen Michael Burleigh, Alexandra Croft, Stephen Jacob Goldfless, David Jeffrey Huss, Yue Jiang, Timothy G. Johnstone, David Koppstein, Hieu Nguyen, Christopher Heath Nye, Haley Peper, Blythe D. Sather, Sonia Timberlake, Dean Y. Toy, Queenie Vong, Gordon Grant Welstead, James Sissons
  • Publication number: 20240106514
    Abstract: A weight determining method and a related apparatus, to reduce a beam gain loss caused by a beam selection deviation are described. The method includes receiving an uplink reference signal and obtaining a channel reciprocity parameter between an uplink channel and a downlink channel based on the uplink reference signal. The method further includes determining state information of the downlink channel based on the channel reciprocity parameter, carrier frequency information of the uplink channel, and carrier frequency information of the downlink channel. Moreover, the method includes determining a weight of a downlink reference signal based on the state information of the downlink channel.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 28, 2024
    Inventors: Shuang Qiu, Zhiyong Wang, Yue Jiang, Jianqiang Yang
  • Publication number: 20240020970
    Abstract: The present disclosure relates to a PointEFF method for urban object classification with LiDAR point cloud data, and belongs to the field of LiDAR point cloud classification. The method comprises: point cloud data segmentation; End-to-end feature extraction layer construction; External feature fusion layer construction; and precision evaluation.
    Type: Application
    Filed: July 14, 2023
    Publication date: January 18, 2024
    Applicant: GUILIN UNIVERSITY OF TECHNOLOGY
    Inventors: Guoqing ZHOU, Yue JIANG, Haoyu WANG
  • Publication number: 20240018053
    Abstract: A ceramic substrate includes: (a) 10 to 70 wt % of silicon carbide; (b) 6 to 60 wt % of aluminum oxide; (c) 5 to 45 wt % of silicon dioxide; and (d) 0 to 15 wt %, excluding 0, of glass powder. Each component is provided as a raw material. A weight percentage of each component is based on a mass percentage of each component.
    Type: Application
    Filed: July 21, 2023
    Publication date: January 18, 2024
    Inventors: Haihua LI, Zhichao CHEN, Yue JIANG, Shaobin XIANG
  • Publication number: 20230354897
    Abstract: A ceramic substrate is provided. A thickness of the ceramic substrate ranges from 1 to 4 mm, and a thermal conductivity of the ceramic substrate ranges from 0.8 to 2.5 W/m·k. In an embodiment, the thickness of the ceramic substrate ranges from 1.5 to 3 mm. In an embodiment, the thermal conductivity of the ceramic substrate ranges from 1.0 to 2.0 W/m·k.
    Type: Application
    Filed: July 21, 2023
    Publication date: November 9, 2023
    Inventors: Zhichao CHEN, Xianjun FU, Yue JIANG
  • Publication number: 20230314039
    Abstract: An HVAC system is provided that is modular. The system may contain condenser modules, heat exchanger modules, and heat pump modules that can replace each other. Heat generated from the condenser modules may be recycled by the heat exchanger modules and/or the heat pump modules, using the air flowing in the system as the medium.
    Type: Application
    Filed: April 4, 2023
    Publication date: October 5, 2023
    Inventor: Yue Jiang
  • Publication number: 20230244621
    Abstract: Techniques are described herein that are capable of reducing interrupts using buffering for data processing. In a first example, information is received at an operating system from an application. The information indicates multiple buffers, including a triggering buffer to trigger an interrupt from hardware. Portions of the data are stored in the respective buffers. A schedule for processing the buffers is provided to the hardware. The schedule indicates that the interrupt is to be delayed until the triggering buffer is processed by the hardware. In a second example, a network interface controller is configured to provide one interrupt to the operating system for each of multiple subsets of network packets that is processed by the network interface controller. Each subset includes a number of the network packets that is greater than one. The network packets are associated with a common network socket.
    Type: Application
    Filed: May 17, 2022
    Publication date: August 3, 2023
    Inventors: Glenn F. EVANS, Yue JIANG
  • Publication number: 20230180840
    Abstract: A vaporization core for heating and vaporizing an aerosol-generation substrate includes: a first substrate having a first surface and a second surface opposite the first surface, the first surface being provided with a first microgroove array, the first microgroove array including a plurality of first microgrooves, the plurality of first microgrooves guiding a flowing of an aerosol-generation substrate, the first substrate including a dense material; and a first heating element arranged on the second surface for heating the first substrate to vaporize the aerosol-generation substrate in the plurality of first microgrooves.
    Type: Application
    Filed: February 9, 2023
    Publication date: June 15, 2023
    Inventors: Ming LV, Zhiqiang SHI, Yue JIANG
  • Publication number: 20230178239
    Abstract: The present disclosure relates to methods for identifying features, such as attributes of subjects, therapeutic cell compositions, and input compositions used to produce therapeutic cell compositions, associated with clinical responses of subjects, e.g., patients, following treatment with the therapeutic cell composition in connection with a cell therapy. The cells of the therapeutic cell composition express recombinant receptors such as chimeric receptors, e.g., chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). The methods provide for the identification of features associated with clinical responses. In some embodiments, the methods can be used to determine (e.g., predict) a subject's response to treatment with the therapeutic cell composition.
    Type: Application
    Filed: May 12, 2021
    Publication date: June 8, 2023
    Applicant: Juno Therapeutics, Inc.
    Inventors: Ronald James HAUSE, JR., Yue JIANG
  • Patent number: 11571689
    Abstract: The invention is mainly related to a synthesis method of supported two-dimensional transition metal carbides for Fenton-like catalysis, which includes the following steps: (1) preparing two-dimensional transition metal carbides powders; (2) dispersing the two-dimensional transition metal carbides powders into intercalants solution to perform an intercalation reaction, and then centrifuging, washing, and freeze-drying to obtain intercalated products; (3) dispersing a certain quality previously obtained intercalated powders into ultrapure water and heating for pre-reaction, and then adding hydrogen peroxide solution to the pre-reacted mixed solution under ice-water bath for secondary etching, resting, centrifuging and gently decanting a supernatant to obtain the final Fenton-like catalysts.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: February 7, 2023
    Assignee: TONGJI UNIVERSITY
    Inventors: Yue Jiang, Sijie Lin
  • Publication number: 20220412954
    Abstract: Provided are methods for determining or predicting attributes of therapeutic cell compositions in connection with cell therapy. The cells of the therapeutic cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). The methods provide for the identification of correlations between input composition (e.g., starting material derived from subjects for producing a cell therapy) attributes and therapeutic cell composition attributes.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 29, 2022
    Applicant: Juno Therapeutics, Inc.
    Inventors: Ronald James HAUSE, JR., Afshin MASHADI-HOSSEIN, Yue JIANG
  • Patent number: D965737
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 4, 2022
    Inventor: Yue Jiang Lai
  • Patent number: D967919
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: October 25, 2022
    Inventor: Yue Jiang Lai