Abstract: A bumper body-part assembly, including a cavity at least partially enclosed by a bumper member and a body part and a sound generator assembly at least partially arranged in the cavity. The sound generator assembly includes a housing assembly with at least one speaker, an electronic assembly and a fastener. The housing assembly includes a deformation assembly arranged in the cavity.

Abstract: A model file management method includes that a terminal device receives a storage address of a target model file package from a server and the terminal device obtains the target model file package based on the storage address of the target model file package, where the target model file package is based on a parameter of a model file package locally stored in the terminal device and a parameter of a model file package managed by the server. In an artificial intelligence (AI) field, an application may implement a specific function by using an AI model file. An application is decoupled from an AI model file such that the terminal device performs centralized management on a general model file.

Abstract: An electronic device receives a first user operation. The first user operation is used to request to install a first plug-in related to a first application, the first application includes a first plug-in framework and at least one plug-in associated with the first plug-in framework, a major version number of each of the at least one plug-in is the same as a major version number of the first plug-in framework, and the first plug-in is different from the at least one plug-in. The electronic device receives the first plug-in from a server. The electronic device detects whether a major version number of the first plug-in is the same as the major version number of the first plug-in framework. If yes, the electronic device installs the first plug-in.

Abstract: The invention relates to a method of determining a structure of ribonucleic acid (RNA) molecules, the method comprising: contacting the RNA molecules with a modifying agent to obtain modified RNA molecules; reverse transcribing the modified RNA molecules; sequencing the product obtained from the preceding step to generate sequencing reads; and analysing the sequencing reads to determine the structure of the RNA molecules. In a preferred embodiment, the RNA molecules consist of RNA molecules of a single cell, and the modifying agent is 2-methylnicotinic acid imidazolide-azide (NAI-N3). There is also provided a method of classifying cells into one or more cell populations, the method comprising: determining the structure of RNA molecules in each cell; and classifying the cells into one or more cell populations based on similarity in the structure of their RNA molecules.

Abstract: The invention relates to a method for analysing ribonucleic acid (RNA) interactions comprising: a) cross-linking base-paired nucleotides of at least one RNA molecule and/or at least one pair of RNA molecules using a tagged, reversible cross-linking agent (preferably tagged-psoralen) under ultraviolet irradiation; b) fragmenting the said cross-linked RNA molecule(s); c) using said tag to extract said cross-linked RNA fragment(s); d) ligating the said cross-linked RNA fragment(s) to produce cross-linked ligated RNA chimera(s); e) reversing the cross-linking of the said agent to the said RNA molecule(s); f) preparing a sequence library by sequencing the ligated RNA chimera molecule(s) or pair(s); and g) analysing the sequence library to determine RNA interactions. Also disclosed is a method of studying a subject by analysing RNA interactions and attributing them to a clinical picture, or a drug discovery method by attributing an efficacy score to the drug based upon determined RNA interactions.

Abstract: The invention relates to a method for analysing ribonucleic acid (RNA) interactions comprising: a) cross-linking base-paired nucleotides of at least one RNA molecule and/or at least one pair of RNA molecules using a tagged, reversible cross-linking agent (preferably tagged-psoralen) under ultraviolet irradiation; b) fragmenting the said cross-linked RNA molecule(s); c) using said tag to extract said cross-linked RNA fragment(s); d) ligating the said cross-linked RNA fragment(s) to produce cross-linked ligated RNA chimera(s); e) reversing the cross-linking of the said agent to the said RNA molecule(s); f) preparing a sequence library by sequencing the ligated RNA chimera molecule(s) or pair(s); and g) analysing the sequence library to determine RNA interactions. Also disclosed is a method of studying a subject by analysing RNA interactions and attributing them to a clinical picture, or a drug discovery method by attributing an efficacy score to the drug based upon determined RNA interactions.

Abstract: An infrared focal plane readout integrated circuit that includes a unit bias circuit, an integrating circuit, and an on-chip analog-to-digital conversion circuit, where the integrating circuit includes a first switch tube, a second switch tube, and an integrating capacitor; an output end of the unit bias circuit is connected to an input end of the first switch tube; an input end of the second switch tube is connected to a set terminal; both an output end of the first switch tube and an output end of the second switch tube are connected to one end of an integrating capacitor and an input end of the on-chip analog-to-digital conversion circuit; the other end of the integrating capacitor is grounded; and the on-chip analog-to-digital conversion circuit includes a first inverter, a second inverter, a third inverter, an exclusive-OR gate, a built-in sequence counter, and a register.

Abstract: Provided are methods of predicting a pairability of nucleotides of a plurality of RNA polynucleotides by (a) simultaneously determining a paired state or an unpaired state of nucleotides of the plurality of RNA polynucleotides; and (b) corresponding the paired state or the unpaired state of the nucleotides to a database of nucleic acid sequences, the database comprises nucleic acid sequences representing the plurality of RNA polynucleotides, thereby determining the pairability of nucleotides of the plurality of RNA polynucleotides. Also provided are methods of determining a secondary structure of a plurality of RNA molecules; methods of determining if a molecule is capable of modulating a secondary structure of at least one RNA polynucleotide of a plurality of RNA polynucleotides; and methods of screening for a marker associated with a pathology.