Patents by Inventor Yuefei Shen

Yuefei Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPLEXES FOR GENE DELETION AND EDITING
    Publication number: 20230183752
    Abstract: Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.
    Type: Application
    Filed: October 26, 2022
    Publication date: June 15, 2023
    Inventors: Michael P. CZECH, Yuefei SHEN
  • Complexes for gene deletion and editing
    Patent number: 11519009
    Abstract: Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 6, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Michael P. Czech, Yuefei Shen
  • COMPLEXES FOR GENE DELETION AND EDITING
    Publication number: 20190316156
    Abstract: Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.
    Type: Application
    Filed: January 8, 2018
    Publication date: October 17, 2019
    Inventors: Michael P. CZECH, Yuefei SHEN
  • PEPTIDE-AND AMINE-MODIFIED GLUCAN PARTICLES FOR DELIVERY OF THERAPEUTIC CARGOES
    Publication number: 20160184449
    Abstract: The present invention generally relates to peptide-modified glucan particles (PcGPs) and/or amine-modifies glucan particles (amGPs) for use in delivering payload molecules, in particular, nucleic acid payload molecules, to cells. The invention relates to particular peptides and small molecule amines which are ideally suited for use in the pcGPs and amGPs of the invention, respectively. Preferred aspects of the invention feature a single-component delivery vehicle comprising the pcGPs or amGPs and siRNA, for use as an siRNA delivery vehicle. Methods of making such particles and methods of using such particles, for example, for in mediating in vitro and in vivo gene silencing are disclosed herein.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 30, 2016
    Inventors: Michael P. Czech, Jessica L. Cohen, Myriam Aouadi, Yuefei Shen