Patents by Inventor Yuefeng Xie

Yuefeng Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods of Using siRNA to Knockdown Gene Expression and to Improve Solid Organ and Cell Transplantation
    Publication number: 20100028848
    Abstract: This invention describes compositions and methods using siRNA to target various genes expressed in cells of transplanted organs or tissues and/or genes expressed in the host to improve the success of the transplantation.
    Type: Application
    Filed: November 30, 2006
    Publication date: February 4, 2010
    Applicant: Intradigm Corporation
    Inventors: Marie Denise Parker, Julian Roy Pratt, Yijia Liu, Yang Lu, Martin Woodle, Yuefeng Xie
  • Method of using waste tires as a filter media
    Patent number: 6969469
    Abstract: The present invention is a method of using crumb rubber from recycled tires as a filter media. The use of crumb rubber as a media differs from conventional sand or anthracite filters in several ways. The crumb rubber media is compressible which allows the porosity between rubber particles to decrease through the filter bed. The crumb rubber media compresses as headloss increases, allowing for better effluent quality late in the run. The crumb rubber media allows greater depth filtration. The crumb rubber media can be used at high filter rates, greater than 20 gpm/ft2. The crumb rubber media performs similarly to other traditional filter media in respect to turbidity and total suspended solids removal. The crumb rubber media properties are closely tied to media size and shape, with smaller media providing better effluent qualities and larger media allowing longer filter runs at higher flow rates.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 29, 2005
    Assignee: The Penn State Research Foundation
    Inventor: Yuefeng Xie
  • Novel oncolytic adenoviral vectors
    Publication number: 20030104625
    Abstract: The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Cheng Cheng, Lori Clarke, Sheila Connelly, David Leonard Ennist, Suzanne Forry-Schaudies, Mario Gorziglia, Paul L. Hallenbeck, Carl M. Hay, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps, Seshidhar Reddy Police, Patricia Clare Ryan, David A. Stewart, Yuefeng Xie
  • Compositions and methods for the use of ribozymes to determine gene function
    Patent number: 6355415
    Abstract: The present invention provides nucleic acid sequences and methods to define gene function. In particular, the present invention relates to reducing the levels of RNA encoded by a DNA sequence of interest using ribozymes. The present invention further relates to ribozyme sequences, recombinant expression vectors encoding ribozymes as well as host cells and transgenic organisms comprising such expression vectors, and the use of these compositions for the determination of gene function.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: March 12, 2002
    Assignee: Ohio University
    Inventors: Thomas E. Wagner, Yuefeng Xie