Abstract: The present disclosure provides a bispecific antibody including a binding domain that binds to CD112R and a binding domain that binds to TIGIT, and the binding domain that binds to CD112R includes: HCDR1, HCDR2 and HCDR3 of the amino acid sequence set forth in SEQ ID NO: 1, and/or LCDR1, LCDR2 and LCDR3 of the amino acid sequence set forth in SEQ ID NO: 2; and the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 and LCDR3 are defined according to the Kabat, IMGT, Chothia, AbM or Contact numbering system. The present disclosure further provides a polynucleotide encoding the antibody, an expression vector, a host cell and a method for expressing and purifying the antibody, a pharmaceutical composition including the antibody of the present disclosure, and use of the bispecific antibody for treating cancer.

Abstract: A foaming and dyeing integrated production method for a polymer material product includes steps of putting a polymer material preform into a foaming and dyeing kettle, and loading dye into a dyeing circulation module; gasifying CO2 and injecting the CO2 into the foaming and dyeing kettle, stopping pressurization when the CO2 reaches a supercritical state; performing a dyeing circulation process in which the CO2 in the supercritical state enters the dyeing circulation module and dissolves the dye in the dyeing circulation module, when the dyeing process is finished, injecting CO2 and/or N2 pressurized in the fluid pressurization delivery module and heated in the fluid heating module into the foaming and dyeing kettle, stopping pressurization and starting foaming operation when requirements of a foaming process are met; and when the foaming process is finished, taking out a foamed and dyed polymer material product in the foaming and dyeing kettle.

Abstract: The present invention discloses a foaming and dyeing integrated production line for a polymer material product, and a method thereof. The production line comprises a foaming and dyeing kettle, a pressure control module, a dye separation module, a fluid liquefaction and storage module, a fluid pressurization delivery module, a fluid heating module and a dyeing circulation module. The production line integrates the functions of one-step foaming and supercritical fluid dyeing of polymer material, thereby being simple in structure, comprehensive in function, convenient to operate, high in production efficiency, good in product quality and low in cost; besides, the production line can carry out both dyeing and foaming operations, only foaming operation or only dyeing operation on polymer material.

Abstract: A foaming and dyeing integrated production method for a polymer material product includes steps of putting a polymer material preform into a foaming and dyeing kettle, and loading dye into a dyeing circulation module; gasifying CO2 and injecting the CO2 into the foaming and dyeing kettle, stopping pressurization when the CO2 reaches a supercritical state; performing a dyeing circulation process in which the CO2 in the supercritical state enters the dyeing circulation module and dissolves the dye in the dyeing circulation module, when the dyeing process is finished, injecting CO2 and/or N2 pressurized in the fluid pressurization delivery module and heated in the fluid heating module into the foaming and dyeing kettle, stopping pressurization and starting foaming operation when requirements of a foaming process are met; and when the foaming process is finished, taking out a foamed and dyed polymer material product in the foaming and dyeing kettle.

Abstract: The invention discloses a horizontal supercritical fluid foaming autoclave with an internal stirring device, comprising a horizontal autoclave body, an end cover, a stirring driver and a stirring paddle, wherein a stirring shaft of the stirring driver passes through the autoclave body and is connected with the stirring paddle positioned inside the autoclave body. The stirring driver of the invention can drive the stirring paddle to rotate, drive the fluid in the autoclave body to generate convection circulation, increase convection heat transfer, improve a uniform distribution degree of the temperature in the autoclave, enable the temperature in each position in the autoclave body to be consistent, ensure the consistency of the shape and parameters of foamed products, and improve the yield of the products.

Abstract: The invention discloses a horizontal supercritical fluid autoclave and an apparatus thereof, and the autoclave including an autoclave body, an end cover, a material frame, a wedge block and a wedge block driving device, wherein the autoclave body is horizontally arranged, and the wedge block driving device can drive the wedge block to move in the radial direction, so that the wedge block can be clamped into a clamping groove at the inner wall of the open end of the autoclave body to lock the end cover or can be separated from the clamping groove of the autoclave body to open the cover. The end cover is small in size and light in weight, and the wedge block type cover mechanism with quick unlocking and locking is adopted; and the structure is simple, the opening/closing of the end cover is simpler and more convenient, and the installation space is saved.

Abstract: The present invention discloses a foaming and dyeing integrated production line for a polymer material product, and a method thereof. The production line comprises a foaming and dyeing kettle, a pressure control module, a dye separation module, a fluid liquefaction and storage module, a fluid pressurization delivery module, a fluid heating module and a dyeing circulation module. The production line integrates the functions of one-step foaming and supercritical fluid dyeing of polymer material, thereby being simple in structure, comprehensive in function, convenient to operate, high in production efficiency, good in product quality and low in cost; besides, the production line can carry out both dyeing and foaming operations, only foaming operation or only dyeing operation on polymer material.

Abstract: The invention discloses a polymer material supercritical fluid foaming autoclave with internal heat exchange, comprising a horizontal autoclave body, an end cover and a spiral heat exchange coil pipe, wherein the heat exchange coil pipe is positioned inside the autoclave body and is mounted against an inner wall of the autoclave body, and a high/low-temperature heat exchange medium can be introduced into the heat exchange coil pipe. According to the invention, the internal heat exchange coil pipe is adopted for heat exchange, so that the heat exchange medium can directly and efficiently exchange heat with the supercritical fluid in the autoclave, and the heat exchange efficiency is improved, which solves the problems of temperature control delay and low efficiency due to the fact that the heat exchange is carried out only by a jacket of the autoclave body in common use at present.

Abstract: The invention discloses a horizontal supercritical fluid foaming autoclave with an internal stirring device, comprising a horizontal autoclave body, an end cover, a stirring driver and a stirring paddle, wherein a stirring shaft of the stirring driver passes through the autoclave body and is connected with the stirring paddle positioned inside the autoclave body. The stirring driver of the invention can drive the stirring paddle to rotate, drive the fluid in the autoclave body to generate convection circulation, increase convection heat transfer, improve a uniform distribution degree of the temperature in the autoclave, enable the temperature in each position in the autoclave body to be consistent, ensure the consistency of the shape and parameters of foamed products, and improve the yield of the products.

Abstract: The invention discloses a horizontal supercritical fluid autoclave and an apparatus thereof, and the autoclave including an autoclave body, an end cover, a material frame, a wedge block and a wedge block driving device, wherein the autoclave body is horizontally arranged, and the wedge block driving device can drive the wedge block to move in the radial direction, so that the wedge block can be clamped into a clamping groove at the inner wall of the open end of the autoclave body to lock the end cover or can be separated from the clamping groove of the autoclave body to open the cover. The end cover is small in size and light in weight, and the wedge block type cover mechanism with quick unlocking and locking is adopted; and the structure is simple, the opening/closing of the end cover is simpler and more convenient, and the installation space is saved.

Abstract: A planning system for planning the landscaping of a particular piece of land in terms of carbon footprint models predefined types of stormwater management infrastructure and assists a user in constructing a plan for managing the land's stormwater according to carbon footprint. The net carbon footprint of the plan is calculated according to type-specific equations that formulate carbon embodied in the materials, emitted during the construction, emitted during the maintenance, and sequestered by the materials of the one or more types of stormwater management infrastructure employed by the plan. The user is then presented with information useful for determining the net carbon footprint or determining a plan that most closely achieves a target net carbon footprint.

Abstract: An improved aqueous cathodic electrocoating composition having a binder of an epoxy-amine adduct which is an epoxy resin that has been reacted with an amine, a blocked polyisocyanate crosslinking agent and an organic or inorganic acid as the neutralizing agent for the epoxy amine adduct; where the improvement is a catalyst of an alkyl tin oxide that has been dissolved with an organic or inorganic acid to provide a clear cathodic electrocoating composition.

Abstract: An improved aqueous cathodic electrocoating composition having a binder of an epoxy-amine adduct which is an epoxy resin that has been reacted with an amine, a blocked polyisocyanate crosslinking agent and an organic or inorganic acid as the neutralizing agent for the epoxy amine adduct; where the improvement is a catalyst of an alkyl tin oxide that has been dissolved with an organic or inorganic acid to provide a clear cathodic electrocoating composition.