Patents by Inventor Yuelei SHEN

Yuelei SHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TNFRSF9 ANTIBODIES AND USES THEREOF
    Publication number: 20240092922
    Abstract: This disclosure relates to anti-TNFRSF9 (tumor necrosis factor receptor superfamily member 9) antibodies, antigen-binding fragments, and the uses thereof.
    Type: Application
    Filed: September 11, 2023
    Publication date: March 21, 2024
    Inventors: Yi Yang, Jingshu Xie, Chunyan Dong, Fang Yang, Chengyuan Lu, Yuelei Shen, Jian Ni, Yanan Guo, Yunyun Chen
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GLP1R
    Publication number: 20230363362
    Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) GLP1R, and methods of use thereof.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CCR8
    Publication number: 20230320332
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CCR8, and methods of use thereof.
    Type: Application
    Filed: September 10, 2021
    Publication date: October 12, 2023
    Inventors: Yuelei SHEN, Yang BAI, Chaoshe GUO, Meiling ZHANG, Rui HUANG, Chengzhang SHANG
  • ANTI-CLAUDIN 18.2 ANTIBODY AND ANTIBODY-DRUG CONJUGATE THEREOF
    Publication number: 20230272109
    Abstract: Provided are an antibody targeting Claudin 18.2, an antibody-drug conjugate, and use thereof in treatment of cancer. Also provided are a nucleotide encoding the Claudin 18.2 antibody, a polynucleotide combination, an expression vector, an expression vector combination, a pharmaceutical composition comprising the Caudill 18.2 antibody and the antibody-drug conjugate, and an application thereof in preparation of a medication for treatment or prevention of cancer.
    Type: Application
    Filed: May 7, 2022
    Publication date: August 31, 2023
    Inventors: Jianmin FANG, Yuanhao LI, Marie M. ZHU, Jing JIANG, Yuelei SHEN, Shenjun LI, Wenting LUO, Xiaoping ZHANG, Lili WANG, Ling WANG, Qinbin ZHANG, Fang YANG
  • Genetically modified non-human animals with humanized immunoglobulin locus
    Patent number: 11730151
    Abstract: The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: August 22, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Jiawei Yao, Huizhen Zhao, Yabo Zhang, Lili Liu, Hui Lu, Shuwen Huang
  • Genetically modified mice expressing humanized CD47
    Patent number: 11723348
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: August 15, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yang Bai, Jian Ni, Rui Huang, Chengzhang Shang, Yanan Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL EXPRESSING A B2M/FCRN FUSION PROTEIN
    Publication number: 20230227531
    Abstract: The present disclosure relates to genetically modified non-human animals that express a fusion protein including B2M and FcRn, and methods of use thereof. In some embodiments, the animals can have a B-NDG background. In some embodiments, the endogenous B2M gene is knocked out in the animals.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 20, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • ANTI-PD-1/CD40 BISPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20230220082
    Abstract: This disclosure relates to antigen-binding protein constructs (e.g., bispecific antibodies or antigen-binding fragments thereof), wherein the antigen-binding protein constructs specifically bind to two different antigens (e.g., PD-1 and CD40).
    Type: Application
    Filed: January 5, 2023
    Publication date: July 13, 2023
    Inventors: Baihong Liu, Yi Yang, Yuelei Shen
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD94 AND/OR NKG2A
    Publication number: 20230172171
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD94 and/or NKG2A, and methods of use thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 8, 2023
    Inventors: Yuelei Shen, Yang Bai, Chaoshe Guo, Meiling Zhang, Rui Huang, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD276
    Publication number: 20230165227
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD276, and methods of use thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 1, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Yanan Guo, Lei Zhao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD38
    Publication number: 20230148574
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD38, and methods of use thereof.
    Type: Application
    Filed: April 1, 2021
    Publication date: May 18, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Yanan Guo, Lei Zhao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL1B AND/OR IL1A
    Publication number: 20230148575
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL1B and/or IL1A, and methods of use thereof.
    Type: Application
    Filed: April 7, 2021
    Publication date: May 18, 2023
    Inventors: Yuelei Shen, Meiling Zhang, Rui Huang, Yang Bai, Chaoshe Guo, Xiaofei Zhou
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH COMMON LIGHT CHAIN IMMUNOGLOBULIN LOCUS
    Publication number: 20230128645
    Abstract: This disclosure relates to genetically modified animals and cells with humanized light chain immunoglobulin locus and/or humanized heavy chain immunoglobulin locus. In one aspect, the endogenous light chain immunoglobulin locus comprises a limit number of human IGKV genes and human IGKJ genes.
    Type: Application
    Filed: October 19, 2022
    Publication date: April 27, 2023
    Inventors: Yabo Zhang, Hui LU, Huizhen ZHAO, Jiawei Yao, Yi Yang, Yuelei Shen
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC MHC PROTEIN COMPLEX
    Publication number: 20230072216
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) major histocompatibility complex (MHC) protein complex, and methods of use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS
    Publication number: 20230064196
    Abstract: The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.
    Type: Application
    Filed: October 12, 2022
    Publication date: March 2, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Huizhen ZHAO, Yabo ZHANG, Lili Liu, Hui LU, Shuwen HUANG
  • GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPa/CD47
    Publication number: 20230058049
    Abstract: This disclosure relates to genetically modified immunodeficient animals which express a human or chimeric (e.g., humanized) SIRP? and/or human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Application
    Filed: December 31, 2020
    Publication date: February 23, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Chengzhang Shang
  • MODIFIED IMMUNOGLOBINS
    Publication number: 20230041757
    Abstract: This disclosure relates to modified immunoglobulins.
    Type: Application
    Filed: July 29, 2022
    Publication date: February 9, 2023
    Inventors: Yuan GUO, Baihong LIU, Yi YANG, Yuelei SHEN
  • HUMANIZED TRANSGENIC ANIMAL
    Publication number: 20230043907
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • Genetically modified non-human animal with human or chimeric LAG3
    Patent number: 11564381
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) LAG3, and methods of use thereof.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: January 31, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMAN OR CHIMERIC THPO
    Publication number: 20220408704
    Abstract: The present disclosure relates to genetically modified non-human animals expressing human or chimeric (e.g., humanized) Thrombopoietin (THPO), and methods of use thereof.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 29, 2022
    Inventors: Yuelei Shen, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang