Abstract: The disclosure provides IL-7 fusion proteins as well as compositions comprising them. The disclosure further provides methods of treating and/or preventing lymphopenia or immunodeficiency in a subject, wherein the method includes administering a fusion protein as described herein.

Abstract: A coil device includes a bobbin including a hollow cylindrical portion and first and second flanges disposed at ends of the hollow cylindrical portion, and having a first partition located between the first and second flange and a second partition located between the first partition and second flange; the first winding wound around the outer periphery of the hollow cylindrical portion between first partition and the first flange; the second winding wound around the outer peripheral surface of the hollow cylindrical portion between the first partition and the second flange, and wound around both sides of the second partition according to a predetermined position. The coil device can wind the winding wire of the second winding at a predetermined position, thereby reinforcing the secondary side magnetic coupling while controlling or reducing the leakage inductance manufacturing error between the primary and secondary side due to difference in the secondary side winding.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate a category Bayesian hierarchical model. One method includes receiving a brand data set for each of a plurality of brands within a category, each brand data set comprising content input for a particular brand of the plurality of brands for a plurality of media channels at a plurality of times and a response for the particular brand of the plurality of brands at the plurality of times. The method includes determining a plurality of informative priors by generating a category Bayesian hierarchical model based on the plurality of brand data sets and a plurality of weak priors. The method further includes generating a brand Bayesian hierarchical model that models response for the particular brand for each of the plurality of media channels based on the brand data set for the particular brand and the plurality of informative priors.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate a Bayesian hierarchical model. One method includes generating a plurality of geographic regions by grouping one or more geographic sub-regions into each of the plurality of geographic regions. The method further includes receiving data for the geographic sub-regions, the data including responses, content inputs, content types, and location identifiers. The method further includes generating geo-level data from the received data by grouping the responses and content inputs of the received data based on a correlation of the location identifiers of the received data to the plurality of geographic regions. The method includes fitting a Bayesian hierarchical model based on at least the geo-level data, the content types, and the geographic regions and determining a content input mix for the content types for each geographic region based on the Bayesian hierarchical model and a content input constraint.

Abstract: A coil device includes a bobbin including a hollow cylindrical portion and first and second flanges disposed at ends of the hollow cylindrical portion, and having a first partition located between the first and second flange and a second partition located between the first partition and second flange; the first winding wound around the outer periphery of the hollow cylindrical portion between first partition and the first flange; the second winding wound around the outer peripheral surface of the hollow cylindrical portion between the first partition and the second flange, and wound around both sides of the second partition according to a predetermined position. The coil device can wind the winding wire of the second winding at a predetermined position, thereby reinforcing the secondary side magnetic coupling while controlling or reducing the leakage inductance manufacturing error between the primary and secondary side due to difference in the secondary side winding.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate causal models and calculate a selection bias in mixed media. In some embodiments, the selection bias calculation is in search sponsored content in the context of mixed media modeling. In some embodiments, a method for search bias correction is based on the back-door criterion from causal inference.

Abstract: Methods and systems of reducing computer resource utilization to update rankings based on dynamically generated content are described. The method includes identifying a ranking of content experience types of a list of content experience types. Each content experience type including parameters to generate content experience documents. The method also includes updating the ranking of content experience types. The updating includes iteratively selecting content experience types from the ranking of content experience types to generate an update subset of the ranking of content experience types, generating, for a client device, a feedback request document including a plurality of content experience documents, and receiving feedback information related to the plurality of content experience documents included in the feedback request document to update the ranking of the content experience types included in the update subset.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate causal models and calculate a selection bias in mixed media. In some embodiments, the selection bias calculation is in search sponsored content in the context of mixed media modeling. In some embodiments, a method for search bias correction is based on the back-door criterion from causal inference.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate a category Bayesian hierarchical model. One method includes receiving a brand data set for each of a plurality of brands within a category, each brand data set comprising content input for a particular brand of the plurality of brands for a plurality of media channels at a plurality of times and a response for the particular brand of the plurality of brands at the plurality of times. The method includes determining a plurality of informative priors by generating a category Bayesian hierarchical model based on the plurality of brand data sets and a plurality of weak priors. The method further includes generating a brand Bayesian hierarchical model that models response for the particular brand for each of the plurality of media channels based on the brand data set for the particular brand and the plurality of informative priors.

Abstract: Systems, methods, and computer-readable storage media that may be used to generate a Bayesian hierarchical model. One method includes generating a plurality of geographic regions by grouping one or more geographic sub-regions into each of the plurality of geographic regions. The method further includes receiving data for the geographic sub-regions, the data including responses, content inputs, content types, and location identifiers. The method further includes generating geo-level data from the received data by grouping the responses and content inputs of the received data based on a correlation of the location identifiers of the received data to the plurality of geographic regions. The method includes fitting a Bayesian hierarchical model based on at least the geo-level data, the content types, and the geographic regions and determining a content input mix for the content types for each geographic region based on the Bayesian hierarchical model and a content input constraint.

Abstract: A switching power supply device includes: a transformer; a first switch connected between a high potential terminal of an input DC voltage source and a primary winding; a second switch connected between a low potential terminal of the input DC voltage source and a primary winding; a control circuit outputting a driving pulse signal for synchronizing the first and second switches; first and second rectifying devices; a synchronous rectifier circuit; and a positive bias circuit that applies a positive bias to a control terminal of one of the first and second switches so as to constantly turn the one of the first and second switches ON. When the first and second switches stop a switching operation while an output voltage exists between the output terminals, the positive bias circuit applies the positive bias to the one of the first and second switches.

Abstract: A switching power supply device includes: a main transformer; a main switch that is connected between a high potential terminal of an input direct current voltage source and a primary-side main winding; a synchronous rectifier circuit includes: a rectifying switch that is connected to a secondary-side main winding in series and that is turned ON in synchronization with a turning ON state of the main switch and a commutation switch that is connected to the rectifying switch series circuit in parallel and that is turned ON in synchronization with a turning OFF state of the main switch; and an auxiliary switch circuit that turns the commutation switch OFF. When the main switch stops a switching operation while a voltage exists at a first output terminal on a high potential side, the auxiliary switch circuit turns the commutation switch OFF to prevent continuation of self-excited oscillation.

Abstract: A power supply circuit includes a plurality of output terminals that output voltages (voltages may have the same or different voltage values among the output terminals), and a transformer that has a plurality of output windings. First and second output windings of the plurality of output windings are coupled to each other. The first and second output windings have the same number of turns. First terminals, which have a first polarity, of the first and second output windings are connected to each other via a capacitor. Further, second terminals, which have a second polarity opposite to the first polarity, of the first and second output windings are electrically connected to each other. The second terminals of the first and second output windings may be directly connected to each other.

Abstract: A switching power supply device includes: a transformer; a first switch connected between a high potential terminal of an input DC voltage source and a primary winding; a second switch connected between a low potential terminal of the input DC voltage source and a primary winding; a control circuit outputting a driving pulse signal for synchronizing the first and second switches; first and second rectifying devices; a synchronous rectifier circuit; and a positive bias circuit that applies a positive bias to a control terminal of one of the first and second switches so as to constantly turn the one of the first and second switches ON. When the first and second switches stop a switching operation while an output voltage exists between the output terminals, the positive bias circuit applies the positive bias to the one of the first and second switches.

Abstract: A switching power supply device includes: a main transformer; a main switch that is connected between a high potential terminal of an input direct current voltage source and a primary-side main winding; a synchronous rectifier circuit includes: a rectifying switch that is connected to a secondary-side main winding in series and that is turned ON in synchronization with a turning ON state of the main switch and a commutation switch that is connected to the rectifying switch series circuit in parallel and that is turned ON in synchronization with a turning OFF state of the main switch; and an auxiliary switch circuit that turns the commutation switch OFF. When the main switch stops a switching operation while a voltage exists at a first output terminal on a high potential side, the auxiliary switch circuit turns the commutation switch OFF to prevent continuation of self-excited oscillation.

Abstract: A power factor improvement circuit is configured with two series circuits each having a switching element and a rectifying element connected in series. Two input terminals of a single-phase AC power source are respectively connected between the switching elements and the rectifying elements in the series circuits. An inductor element is connected between an output terminal of the power factor improvement circuit and two terminals, which are on the other side of the rectifying elements, of the switching elements. A capacitor element is connected between the output terminal and the two terminals. According to the above configuration, it is possible to decrease a loss of a bridge circuit and common-mode noise, and to provide a power factor improvement circuit in a smaller size.

Abstract: A power supply circuit includes a plurality of output terminals that output voltages (voltages may have the same or different voltage values among the output terminals), and a transformer that has a plurality of output windings. First and second output windings of the plurality of output windings are coupled to each other. The first and second output windings have the same number of turns. First terminals, which have a first polarity, of the first and second output windings are connected to each other via a capacitor. Further, second terminals, which have a second polarity opposite to the first polarity, of the first and second output windings are electrically connected to each other. The second terminals of the first and second output windings may be directly connected to each other.

Abstract: A power factor improvement circuit is configured with two series circuits each having a switching element and a rectifying element connected in series. Two input terminals of a single-phase AC power source are respectively connected between the switching elements and the rectifying elements in the series circuits. An inductor element is connected between an output terminal of the power factor improvement circuit and two terminals, which are on the other side of the rectifying elements, of the switching elements. A capacitor element is connected between the output terminal and the two terminals. According to the above configuration, it is possible to decrease a loss of a bridge circuit and common-mode noise, and to provide a power factor improvement circuit in a smaller size.