Abstract: The present invention relates to use of a novel Arf1 inhibitor; a method for treating refractory, recurrent or metastatic cancer using these compounds; an investigate method for selectively killing cancer stem cells and cancer cells using the compounds and a specific dosing regimen; an investigate method for targeting tumor stem cells and inducing an anti-tumor immune response by inhibiting an Arf1 pathway, particularly a COPI/Arf1-lipolysis-?-oxidation pathway; a method for treating Arf1 pathway activity related diseases using a new compound in mammals; a process for preparing the compounds and intermediates thereof; and a pharmaceutical composition of a related compound.

Abstract: The present disclosure relates to the field of tumor drug therapy, in particular to use of a methylaminocolchicine and salts thereof. The use includes use of a methylamino-substituted colchicine at C10 position and salts thereof in preparation of antitumor drugs, use thereof in antitumor drugs for antagonizing microtubule inhibitor resistance, or use thereof in combination an antitumor drug. In the present disclosure, the methylaminocolchicine and the salts thereof have significant antitumor effects, are more active than paclitaxel, vincristine, and colchicine, do not exhibit cross resistance to the paclitaxel and the vincristine, and inhibit paclitaxel-resistant cell growth in vivo. With in vivo acceptable therapeutic indexes, the methylaminocolchicine and the salts thereof have a synergistic antitumor effect when used in combination with an anti-apoptotic protein Bcl-2/Bcl-xL inhibitor.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for online fraud protection. One of the methods includes receiving a query associated with a user account of an online service provider; providing the query to a deep neural network model to generate a prediction of whether the user account is fraudulent, wherein the deep neural network model is trained using anonymized event data for a collection of users received from one or more online service providers; and providing the prediction to the online service provider.

Abstract: Disclosed are uses of NAD+ and/or NAD+ agonists and/or NAD+ inhibitors for preparing a preparation or a kit, and a combination preparation including T cells and NAD+ and/or NAD+ agonists and/or NAD+ inhibitors. The preparation or kit is used for regulating T cell activity, regulating the expression level of CD69 on the surface of T cells, and/or regulating the phosphorylation level in T cells, and/or treating diseases related to T cell activity.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for online fraud protection. One of the methods includes receiving a query associated with a user account of an online service provider; providing the query to a deep neural network model to generate a prediction of whether the user account is fraudulent, wherein the deep neural network model is trained using anonymized event data for a collection of users received from one or more online service providers; and providing the prediction to the online service provider.