Patents by Inventor Yueyong Lei

Yueyong Lei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
    Patent number: 8507250
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 13, 2013
    Assignees: Tsinghua University, Hunan Rivers Biotechnology Co. Ltd.
    Inventors: Dehua Liu, Hongjuan Liu, Xianjin Ou, Yan Sun, Yunzhen Xu, Yueyong Lei, Weibin Liu
  • METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION
    Publication number: 20120258521
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Application
    Filed: June 20, 2012
    Publication date: October 11, 2012
    Applicants: HUNAN RIVERS BIOTECHNOLOGY CO. LTD., TSINGHUA UNIVERSITY
    Inventors: Dehua LIU, Hongjuan LIU, Xianjin OU, Yan SUN, Yunzhen XU, Yueyong LEI, Weibin LIU
  • Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
    Patent number: 8227217
    Abstract: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: July 24, 2012
    Assignees: Tsinghua University, Hunan Rivers Biotechnology Co. Ltd.
    Inventors: Dehua Liu, Hongjuan Liu, Xianjin Ou, Yan Sun, Yunzhen Xu, Yueyong Lei, Weibin Liu
  • METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION
    Publication number: 20110117617
    Abstract: The present invention relates to methods and genetically engineered micro-organisms for the combined production of PDO, BDO, and PHP by fermentation. The micro-organism is characterized in that its D-lactate dehydrogenase gene has been deleted or functionally inactivated, and it comprises heterogenous polynucleotides encoding the Coenzyme A-dependent Aldehyde dehydrogenase and the Polyhydroxyalkanoate synthase.
    Type: Application
    Filed: November 17, 2009
    Publication date: May 19, 2011
    Applicants: TSINGHUA UNIVERSITY, HUNAN RIVERS BIOTECHNOLOGY CO. LTD.
    Inventors: Dehua LIU, Hongjuan LIU, Xianjin OU, Yan Sun, Yunzhen Xu, Yueyong LEI, Weibin LIU