Abstract: A method and device for building an oligonucleotide on a solid phase resin within a filter reactor, wherein the method and device as used as a solid phase synthesis system. As part of the solid phase synthesis process, a protecting group will be removed from the 5? position of an oligonucleotide that is attached to the solid phase resin and then an activated amidite (phosphoamidite) solution is added. The activated amidite solution flows up and down, or fluidizes and mixes with the resin beads within the bed reactor and reacts at the 5? position of the oligonucleotide, wherein the phosphorous linkage found within the amidite comprises a P atom that is in an oxidation state of III. Once the activated amidite solution has been reacted, the P atom is converted from an oxidation state of III to an oxidation state of V. Any of the reactions including deblocking, coupling, oxidation, sulfurization, or capping can be fluidized or mixed to get complete contacting between the reagents and the resin.

Abstract: The present disclosure discloses an intelligent interactive interface, comprising: an interface underlayer drawn from trajectory formed by measurement; a plurality of identifications disposed on the interface underlayer, each of the identifications corresponds to an external device, information of the external device is uploaded in real time, displayed on the interface underlayer and can be stored on a server, and a mapping relationship is established between the information of the external device and the corresponding identification of respective external device; a terminal apparatus is connected to the external device and displays the interface underlayer, identifications and control and/or exchange information with the external device; wherein the information of the external device is displayed in real time on the terminal apparatus through the identifications, the identifications can be added or deleted in real time.

Abstract: The present disclosure discloses an intelligent interactive interface, comprising: an interface underlayer drawn from trajectory formed by measurement; a plurality of identifications disposed on the interface underlayer, each of the identifications corresponds to an external device, information of the external device is uploaded in real time, displayed on the interface underlayer and can be stored on a server, and a mapping relationship is established between the information of the external device and the corresponding identification of respective external device; a terminal apparatus is connected to the external device and displays the interface underlayer, identifications and control and/or exchange information with the external device; wherein the information of the external device is displayed in real time on the terminal apparatus through the identifications, the identifications can be added or deleted in real time.