Publication number: 20250044304
Abstract: The present application relates to an antibody, kit, detection method, and sample analyzer for detecting thyroid stimulating hormone. Specifically, the present application relates to a monoclonal antibody or antigen-binding antibody fragment thereof that specifically binds to thyroid stimulating hormone (TSH), wherein the antibody can recognize TSH variant R55G and does not cross-react with an ?-subunit shared by human luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), and free glycoprotein hormones, and is particularly suitable for developing TSH detection kit with a functional sensitivity of ?0.0015 ?IU/ml. The present application also relates to a thyroid stimulating hormone detection kit, detection method, and sample analyzer.
Type:
Application
Filed:
July 25, 2024
Publication date:
February 6, 2025
Applicants:
SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., HyTest Ltd.
Inventors:
Karina R. Seferian, Evgenia O. Kuzichkina, Erzhena G. Altaeva, Fedor N. Rozov, Stanislav V. Kozlovsky, Yury N. Lezhnin, Kristina M. Gaynova, Liudmila V. Ageeva, Natalia A. Gruzdeva, Natalia N. Tamm, Elizaveta D. Kulieva, Anna A. Trufanova, Sergei A. Kotlov, Chengxiong ZHAN, Qixue SONG, Tao TANG, Yufeng YAN, Ke LI