Abstract: This invention presents the novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs, and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.

Abstract: Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.

Abstract: A method for micro-ridge mixed-sowing cultivation of dryland crops includes the following steps: S1: cleaning ditches and draining away water in dryland; S2: harvesting the preceding crop, leaving the stubble, smashing the stalks of the preceding crop, and then spreading the smashed stalks on the stubble; S3: trenching the dryland to form ecological trenches; S4: flattening the standing stubble and the smashed stalks on the seedbed surface to form an underlying surface, molding seed-fertilizer-soil compounds into a ridge shape and falling the seed-fertilizer-soil compounds on the underlying surface to form ecological ridges, wherein a plurality of ecological ridges are formed between adjacent ecological trenches, an ecological depression is formed between adjacent ecological ridges, and after sowing, an irrigation is carried out once in a manner, wherein the manner includes: draining water shortly after the irrigation, without leaving a water layer in the field.

Abstract: A method for micro-ridge mixed-sowing cultivation of rice includes: S1: draining away water at the maturity stage of the preceding crop until reaching a state allowing a harvester to operate; S2: harvesting the preceding crop, leaving the stubble, smashing the stalks of the preceding crop, and then spreading the smashed stalks on the stubble to form a rhizosphere layer for rice growth; S3: trenching the field to form ecological trenches; S4: flattening the standing stubble and the smashed stalks on the seedbed surface to form an underlying surface, molding seed-fertilizer-soil compounds into a ridge shape and fall the seed-fertilizer-soil compounds on the underlying surface to form ecological ridges, wherein a plurality of ecological ridges are formed between adjacent ecological trenches, and the seed-fertilizer-soil compounds are obtained by thoroughly mixing rice seeds, chemical fertilizers and soil at a mass ratio of 6 to 14:50 to 70:6,000 to 10,000.

Abstract: Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.