Patents by Inventor Yugesh Kharel

Yugesh Kharel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    Publication number: 20230373937
    Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula (I) and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.
    Type: Application
    Filed: September 8, 2021
    Publication date: November 23, 2023
    Inventors: Kevin R. Lynch, Yugesh Kharel, Webster L. Santos, Russell G. Fritzemeier, Ashley N. Peralta
  • INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    Publication number: 20230331683
    Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula (IA) and Formula (I), and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.
    Type: Application
    Filed: September 8, 2021
    Publication date: October 19, 2023
    Inventors: Kevin R. Lynch, Yugesh Kharel, Webster L. Santos, Russell G. Fritzemeier, Ariel Louise Burgio, Christopher Shrader, Daniel Foster
  • INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    Publication number: 20220089581
    Abstract: The present disclosure provides SPNS2 inhibitor compounds according to Formula I and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.
    Type: Application
    Filed: January 22, 2020
    Publication date: March 24, 2022
    Inventors: Kevin R. Lynch, Yugesh Kharel, Webster L. Santos, Ashley Peralta, Russell G. Fritzemeier, Daniel Foster
  • Imidamide sphingosine kinase inhibitors
    Patent number: 9908849
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: March 6, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
  • Long chain base sphingosine kinase inhibitors
    Patent number: 9688668
    Abstract: The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: June 27, 2017
    Assignee: University of Virginia Patent Foundation
    Inventors: Webster L. Santos, Kevin R. Lynch, Timothy L. Macdonald, Andrew Kennedy, Yugesh Kharel, Mithun Rajendra Raje, Joseph Houck
  • IMIDAMIDE SPHINGOSINE KINASE INHIBITORS
    Publication number: 20170166525
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Application
    Filed: August 19, 2016
    Publication date: June 15, 2017
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
  • Imidamide sphingosine kinase inhibitors
    Patent number: 9421177
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: August 23, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
  • LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS
    Publication number: 20150210675
    Abstract: The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.
    Type: Application
    Filed: February 8, 2013
    Publication date: July 30, 2015
    Inventors: Santos L. Webster, Kevin R. Lynch, Timothy L. Macdonald, Andrew Kennedy, Yugesh Kharel, Mithun Rajendra Raje, Joseph Houck
  • Compositions and methods for inhibiting sphingosine kinase
    Patent number: 8686046
    Abstract: Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
    Type: Grant
    Filed: October 2, 2010
    Date of Patent: April 1, 2014
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Yugesh Kharel, Thomas P. Mathews, Brian R. Wamhoff
  • IMIDAMIDE SPHINGOSINE KINASE INHIBITORS
    Publication number: 20120214858
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Application
    Filed: August 16, 2010
    Publication date: August 23, 2012
    Applicant: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
  • COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE
    Publication number: 20110106241
    Abstract: Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
    Type: Application
    Filed: October 2, 2010
    Publication date: May 5, 2011
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Yugesh Kharel, Thomas P. Mathews, Brian R. Wamhoff