Patents by Inventor Yuguang Shi

Yuguang Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1
    Publication number: 20220089582
    Abstract: Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.
    Type: Application
    Filed: September 29, 2021
    Publication date: March 24, 2022
    Inventors: Yuguang SHI, Daqing CHE, Jonathan BAELL, Xiaoyu LIU, Jiasheng FU
  • Compounds useful as inhibitors of ALCAT 1
    Patent number: 11208404
    Abstract: Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 28, 2021
    Assignee: PERENNA PHARMACEUTICALS, INC.
    Inventors: Yuguang Shi, Daqing Che, Jonathan Baell, Xiaoyu Liu, Jiasheng Fu
  • COMPOUNDS USEFUL AS INHIBITORS OF ALCAT 1
    Publication number: 20200109136
    Abstract: Inhibitors of ALCAT1 are described having the general formula: (I). These compounds offer a treatment for aging and age-related diseases.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 9, 2020
    Inventors: Yuguang SHI, Daqing CHE, Jonathan BAELL, Xiaoyu LIU, Jiasheng FU
  • Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
    Patent number: 10526418
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: January 7, 2020
    Assignee: The Penn State Research Foundation
    Inventor: Yuguang Shi
  • Modulators of ACYL-COA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof
    Publication number: 20170320964
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Application
    Filed: July 17, 2017
    Publication date: November 9, 2017
    Inventor: Yuguang Shi
  • Modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
    Patent number: 9708411
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: July 18, 2017
    Assignee: The Penn Research Foundation
    Inventor: Yuguang Shi
  • Modulators of ACYL-COA Lysocardiolipin Acyltransferase 1 (ALCAT1) and Uses Thereof
    Publication number: 20150098938
    Abstract: Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.
    Type: Application
    Filed: February 15, 2013
    Publication date: April 9, 2015
    Applicant: The Penn State Research Foundation
    Inventor: Yuguang Shi
  • Methods using PBK1 for identifying agents that treat metabolic disorders
    Patent number: 8163505
    Abstract: The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a recombinant nucleic acid encoding a PBK1 protein; a method of identifying a PBK1 modulator; a pharmaceutical composition for treatment of type 2 diabetes in a subject; a method of screening for an agent that treats a metabolic disease; delivery of PBK-1 DNA to a subject to stimulate pancreatic beta cell differentiation and/or regeneration; a method for stimulating cell differentiation and/or regeneration in a pancreatic beta cell; usage of transgenic mice with targeted deletion or overexpression of the PBK-1 gene to test efficacy and specificity of PBK-1 modulator compounds.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: April 24, 2012
    Assignee: The Penn State Research Foundation
    Inventors: Yuguang Shi, Guangming Ye
  • Methods and compositions relating to PBK1
    Publication number: 20100146642
    Abstract: The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a recombinant nucleic acid encoding a PBK1 protein; a method of identifying a PBK1 modulator; a pharmaceutical composition for treatment of type 2 diabetes in a subject; a method of screening for an agent that treats a metabolic disease; delivery of PBK-1 DNA to a subject to stimulate pancreatic beta cell differentiation and/or regeneration; a method for stimulating cell differentiation and/or regeneration in a pancreatic beta cell; usage of transgenic mice with targeted deletion or overexpression of the PBK-1 gene to test efficacy and specificity of PBK-1 modulator compounds.
    Type: Application
    Filed: May 22, 2008
    Publication date: June 10, 2010
    Applicant: The Pennsylvania State University
    Inventors: Yuguang Shi, Guangming Ye
  • Reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome
    Patent number: 5998584
    Abstract: The invention provides fragments of GAD.sub.65 that are specifically reactive with at least one class of GAD.sub.65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD.sub.65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: December 7, 1999
    Assignee: Reagents of the University of California
    Inventors: Steinunn Baekkeskov, Wiltrud Richter, Yuguang Shi, Mark Namchuk, John Kim
  • Reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome
    Patent number: 5849506
    Abstract: The invention provides fragments of GAD.sub.65 that are specifically reactive with at least one class of GAD.sub.65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD.sub.65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: December 15, 1998
    Assignee: The Regents of the University of California
    Inventors: Steinunn Baekkeskov, Wiltrud Richter, Yuguang Shi, Mark Namchuk, John Kim
  • Reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome
    Patent number: 5691448
    Abstract: The invention provides fragments of GAD.sub.65 that are specifically reactive with at least one class of GAD.sub.65 autoantibody. Most fragments are substantially free of N-terminal amino acids that would otherwise limit solubility. Different fragment contain epitopes for different classes of GAD.sub.65 autoantibodies. The fragments are used in methods of diagnosing and treating insulin dependent diabetes mellitus and stiff man syndrome.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: November 25, 1997
    Inventors: Steinunn Baekkeskov, Wiltrud Richter, Yuguang Shi, Mark Namchuk, John Kim