Patents by Inventor yuh-Min Chiang

yuh-Min Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190211396
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
    Type: Application
    Filed: December 21, 2018
    Publication date: July 11, 2019
    Inventors: YUH-MIN CHIANG, Douglas B. Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
  • Patent number: 10190165
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: January 29, 2019
    Assignee: Cepheid
    Inventors: Yuh-Min Chiang, Doug Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
  • Patent number: 9914968
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 13, 2018
    Assignee: Cepheid
    Inventors: Yuh-Min Chiang, Doug Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
  • Publication number: 20180016624
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: July 24, 2017
    Publication date: January 18, 2018
    Inventors: Min YUE, David M. LIU, Joy ROY, Yuh-Min CHIANG, Joon Mo YANG, Dennis LEHTO, Charles S. VANN, Nigel P. BEARD, Ian A. HARDING, John R. Van Camp, Alexander DROMARETSKY, Sergey V. ERMAKOV, Mark F. OLDHAM, Maryam SHARIATI, Umberto ULMANELLA
  • Patent number: 9714444
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: July 25, 2017
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20150275292
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
    Type: Application
    Filed: September 26, 2013
    Publication date: October 1, 2015
    Applicant: CEPHEID
    Inventors: Yuh-Min Chiang, Doug Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
  • Publication number: 20150140611
    Abstract: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
    Type: Application
    Filed: October 20, 2014
    Publication date: May 21, 2015
    Inventors: Charles Vann, Michael Greenstein, Yuh-Min Chiang
  • Publication number: 20140162264
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: December 2, 2013
    Publication date: June 12, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20140141438
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 22, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Yuh-Min Chiang, Roy H. Tan, Carol Schembri
  • Publication number: 20140087958
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 27, 2014
    Applicant: CEPHEID
    Inventors: YUH-MIN CHIANG, DOUG DORITY, DUSTIN DICKENS, JENNIFER GLASS, REUEL VAN ATTA
  • Patent number: 8597590
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: December 3, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20110177562
    Abstract: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
    Type: Application
    Filed: December 20, 2010
    Publication date: July 21, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Charles S. Vann, Michael Greenstein, Yuh-Min Chiang
  • Publication number: 20110020179
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: May 27, 2010
    Publication date: January 27, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Min Yue, David M. Liu, Yuh-Min Chiang, Joon-Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Joy Roy, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20090321259
    Abstract: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
    Type: Application
    Filed: April 30, 2009
    Publication date: December 31, 2009
    Applicant: Life Technologies Corporation
    Inventors: Charles S. Vann, Michael Greenstein, yuh-Min Chiang
  • Publication number: 20090081768
    Abstract: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 26, 2009
    Applicant: Applera Corporation
    Inventors: Joon Mo Yang, David M. Liu, Yuh-Min Chiang, Carol Schrembri, Aldrich N.K. Lau, Umberto Ulmanella, Nigel P. Beard, Maryam Shariati, James C. Nurse, Douwe D. Haga, Ian A. Harding, Julio P. Focaracci
  • Publication number: 20080293127
    Abstract: A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.
    Type: Application
    Filed: May 22, 2007
    Publication date: November 27, 2008
    Applicant: Applera Corporation
    Inventors: Yuh-Min Chiang, Aldrich N.K. Lau
  • Publication number: 20070280857
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: June 2, 2006
    Publication date: December 6, 2007
    Applicant: APPLERA CORPORATION
    Inventors: Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Yuh-Min Chiang, Roy H. Tan, Carol Schembri
  • Publication number: 20070141605
    Abstract: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 21, 2007
    Applicant: Applera Corporation
    Inventors: Charles Vann, Michael Greenstein, Yuh-Min Chiang
  • Publication number: 20070014695
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: April 26, 2006
    Publication date: January 18, 2007
    Applicant: Applera Corporation
    Inventors: Min Yue, David Liu, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles Vann, Nigel Beard, Ian Harding, John Van Camp, Alexander Dromaretsky, Sergey Ermakov, Mark Oldham, Joy Roy, Maryam Shariati, Umberto Ulmanella