Abstract: A method for smelting low-phosphorus high-manganese steel based on reduction dephosphorization of ferromanganese is provided in the present application, relating to the technical field of high-manganese steel smelting, where the dephosphorization of ferromanganese is carried out under reducing atmosphere conditions through mediate-frequency induction furnace to obtain molten ferromanganese with lower phosphorus content, which is subsequently mixed with low phosphorus molten steel obtained by smelting in oxidative period of electric arc furnace in LF ladle refining furnace to make the Mn content of steel reach the requirement of high-manganese steel, and smelting is carried out under the condition of reducing atmosphere by adjusting the composition and temperature of the molten steel to meet the requirements of the target composition of the steel grade before tapping the steel.

Abstract: Provided is a method and device for low-carbon integrated energy system scheduling. A specific embodiment of this method comprise: obtaining the energy device information set for each energy device in the virtual power plant; generating the acquisition cost information for each energy device based on an energy device name, energy device parameter information and an energy device number in the energy device information set; generating the energy scheduling objective values and the parameter information of each energy device based on the preset constraint sets and energy acquisition cost information of each energy device; controlling each energy device in the virtual power plant to execute the energy scheduling tasks based on the objective energy device parameter information.

Abstract: A lost circulation detection device includes a first detection member and a second detection member, a first signal transmitter and a first signal receiver are disposed on the first detection member, and the first signal transmitter transmits a signal along an axial direction of a rockshaft so that the first signal receiver acquires data information of drilling fluid in the axial direction of the rockshaft; a fluid channel penetrating through the second detection member is disposed in the second detection member, and the fluid channel is configurable to be in communication with the rockshaft; a second signal transmitter and a second signal receiver are disposed oppositely on two sides of the fluid channel, and the second signal transmitter transmits a signal along a center line of a second accommodating groove, so that the second signal receiver acquires data information of drilling fluid in a circumferential direction of the rockshaft.

Abstract: Disclosed is an antigen peptide with an infectious bronchitis virus (IBV)-specific neutralizing epitope, in which the peptide is a cyclic polypeptide, and the amino acid sequence of the peptide is CSCPYVSYGRFCIQPDGSIKQC. Also disclosed are an IBV specific antibody and a preparation method thereof. Further disclosed is an ELISA method as an alternative to the neutralization potency assay. The disclosure also discloses an ELISA detection kit, and using the established pELISA method to detect IBV antibodies, it is found that the method is positively correlated with anti-IBV neutralizing antibodies, which may be used to evaluate the immune effect of IBV vaccines on IBV infected chickens and to determine the antibody level, thereby benefiting the health management of chicken flocks.

Abstract: The present disclosure relates to the technical field of bone repair and provides a berberine/mineralized collagen-based composite membrane as well as a preparation method and an application thereof. The composite membrane of the present disclosure includes a berberine nanofiber membrane and a mineralized collagen membrane disposed on a unilateral surface of the berberine nanofiber membrane. In the present disclosure, the mineralized collagen with biomimetic mineralization capacity is combined with a Chinese materia medica monomer, berberine, the resulting bilayer composite membrane has a better effect on promoting osteogenesis; in addition, a novel dosage form of berberine is constructed.

Abstract: The present application provides a high-affinity PD-1 mutant polypeptide, and a fusion protein of the PD-1 mutant polypeptide and an antibody (specifically binding to a tumor antigen) and preparation and application thereof.

Abstract: The present disclosure relates to an antibody fragment specifically binding to PSMA, particularly to a single-chain Fv (scfv), a bispecific antibody containing the scFv, and a chimeric antigen receptor (CAR) and the preparation and the use thereof.

Abstract: The present disclosure provides an immunocytokine with IL-15 and IL-15Ra fused to an antibody targeting a tumor cell surface antigen, which can effectively and specifically target the complex of IL-15 and IL-15Ra to tumor microenvironment, and activate relevant immune cells within or in the vicinity of a tumor, thereby achieving the goal of tumor-specific killing, and at the same time, preventing immunotoxicity induced by the systemic hyperactivation of NK cells.

Abstract: A method for improving the uniformity of connection performance of an assembly surface based on zoned hardening is provided. Through a finite element contact analysis of the assembly surface, a topology optimization of the hardening layer layout of the assembly surface is carried out with the aim of improving the uniformity of the connection performance of the assembly surface. The design is based on the optimized theoretical data, and uses the laser hardening technology to realize the zoned differential hardening of the assembly surface. By performing the zoned differential hardening on the assembly surface, the uniformity of the connection performance of the assembly surface can be effectively improved, and the purpose of improving the high cycle fatigue and the vibration of the high-end equipment parts such as aero-engines can be further achieved.

Abstract: Provided are a bispecific molecule and preparation and use thereof. The bispecific molecule includes a molecule that specifically binds an interleukin-1 receptor (IL-1R) and an antibody that targets a free inflammatory factor. The molecule that specifically binds the cell surface interleukin-1 receptor (IL-1R) aggregates the antibody that targets the free inflammatory factor linked thereto on or near the cell surface, thereby the local concentration of the bispecific molecule on or near the cell surface is increased, adverse reactions are avoided, treatment effectiveness is increased and the infection risk of patients is also reduced.

Abstract: Provided are a novel bispecific binding molecule and use thereof. The novel bispecific binding molecule-drug conjugate includes: a) a bispecific binding molecule consisting of a first binding moiety binds a tumor cell surface antigen (T) and a second antigen binding moiety binds to an internalizing effector protein (E), and b) a cytotoxic ingredient covalently conjugated to the bispecific binding molecule. The bispecific binding molecule may specifically exert cytotoxic activity against tumor cells by specifically targeting to the tumor cells through the first antigen binding moiety, and internalizing the cytotoxic ingredient into the tumor cells by the second antigen binding moiety of the bispecific binding molecule.

Abstract: The disclosure provides a method for fast reconfiguration of power supply grid in tens of milliseconds after power grid failure. The master station of fast reconfiguration of power grid concentrates the network status information from the client stations at transformer substations or power plants, and compares it with the built-in control strategy table which deals with possible faults. When an expected power gird disconnection fault is detected, the pre-start switch-on instruction is sent to the client stations with multiple breakers which can reconnect the grid. When the fault is cleared, the client stations shall identify the fault clearing time according to the local information, and send the instruction of synchronous switch-on to the corresponding local breakers which can reconnect the separated grids.

Abstract: A method for preparing an intelligent antibacterial and antioxidative film involves preparing a PVA solution; adding nano-TiO2 to the PVA solution to obtain a PVA-TiO2 solution; determining the optimal amount of nano-TiO2; preparing a PSPC solution; preparing a PSPC-TiO2-PVA solution; and producing a PSPC/TiO2/PVA film. The film has better mechanical performance than saccharide and protein films. Shelf life of food is prolonged as the film possesses antibacterial and antioxidative properties. Furthermore, the film shows different colors in various pH environments. The film has a wide range of applications in food packaging owing to the integration of color development and antibacterial and antioxidative properties.

Abstract: Disclosed are a heterodimeric fusion protein and its preparation and application The heavy chain and the light chain of the first antigen binding domain Fab are fused to N-terminus of two Fc chains, respectively, and on this basis, the second antigen binding domain scfv, Fab2, Fv, nanobody or a biologically active peptide is fused to N-terminus of Fab or C-terminus of the Fc. The heterodimeric fusion protein obtained has the following characteristics: each domain in fusion proteins maintained its antigen binding capacity, functional conformation and pharmaceutical properties; at least one antigen binding domain can bind to antigen monovalently; the heterodimeric fusion proteins have a prolonged half-life due to the Fc fragment.

Abstract: Disclosed is a bispecific antibody, and in particular, a bispecific antibody that simultaneously targets a tumor cell surface antigen and an immune checkpoint protein. A first binding domain of the above molecule is an antibody containing a constant region, a heavy chain variable region, and a light chain variable region. Through the high affinity binding between the first binding domain and the tumor cell surface antigen, the second binding domain for an immune checkpoint fused with the first binding domain is enriched on or near a tumor cell or in a tumor microenvironment, so as to exert a specific killing effect of an effector cell on the tumor cell.

Abstract: The present application belongs to the field of biotechnology and pharmacy, and provides a fusion protein containing a fibronectin type III domain and preparation and application thereof. The structure of the fusion protein comprises a fibronectin type III domain and an insertion sequence, which can maintain the spatial conformation of an inserted protein or an active peptide, and can effectively protect the N-terminal and/or the C-terminal of a target protein, so that the target protein is not easily affected by enzymolysis, and thus obtaining a longer half-life in vivo.

Abstract: The disclosure provides a method for fast reconfiguration of power supply grid in tens of milliseconds after power grid failure. The master station of fast reconfiguration of power grid concentrates the network status information from the client stations at transformer substations or power plants, and compares it with the built-in control strategy table which deals with possible faults. When an expected power gird disconnection fault is detected, the pre-start switch-on instruction is sent to the client stations with multiple breakers which can reconnect the grid. When the fault is cleared, the client stations shall identify the fault clearing time according to the local information, and send the instruction of synchronous switch-on to the corresponding local breakers which can reconnect the separated grids.

Abstract: A method for preparing an intelligent antibacterial and antioxidative film involves preparing a PVA solution; adding nano-TiO2 to the PVA solution to obtain a PVA-TiO2 solution; determining the optimal amount of nano-TiO2; preparing a PSPC solution; preparing a PSPC-TiO2-PVA solution; and producing a PSPC/TiO2/PVA film. The film has better mechanical performance than saccharide and protein films. Shelf life of food is prolonged as the film possesses antibacterial and antioxidative properties. Furthermore, the film shows different colors in various pH environments. The film has a wide range of applications in food packaging owing to the integration of color development and antibacterial and antioxidative properties.

Abstract: The present invention provides a method and apparatus for providing location information of a mobile terminal, which help to shorten the time for determining an anonymous area of a user. The present invention also aims at reducing the size of the anonymous space area as much as possible so as to ensure the quality of a location-based service.