Abstract: A sample crusher, including a main body housing and an electric motor arranged in the main body housing. A swing mechanism is further arranged in the main body housing. The swing mechanism includes a transmission shaft, a swing disk for allowing a grinding tube to be placed thereon, and a circumferential limiting component. The transmission shaft is driven by the electric motor to rotate, an obliquely arranged bearing is sleeved on the transmission shaft, an included angle is formed between an axis of the bearing and an axis of the transmission shaft, the swing disk is mounted on the bearing, the swing disk and the bearing are concentrically arranged, and the swing disk is connected to the circumferential limiting component.

Abstract: The present disclosure provides a sample pretreatment reagent for detecting drug in hair, which comprises a hydroxyl group-containing compound which belongs to a reducing agent capable of cleaving disulfide bonds. The disulfide bonds in hair particles are opened to expose the drug molecules embedded in hair gaps, thus improving the release amount of drug molecules from hair without affecting the structure or property of the drug molecules, so that the drug detection limit of the method for detecting drug in hair is reduced, and the drug molecules in a lower content in hair can be detected.