Patents by Inventor Yuhong GENG

Yuhong GENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigen chimera, antigen composition, vaccine, method of preparing the same and cassette thereof
    Patent number: 10513543
    Abstract: The present invention provides an antigen chimera, comprising: a fusion protein of an antigen and a mucosal immune adjuvant protein monomer capable of forming a multimer; and the mucosal immune adjuvant protein monomer capable of forming the multimer; wherein the mucosal immune adjuvant protein monomer capable of forming the multimer is one selected from cholera toxin B subunit (CTB) and E. coli heat-labile enterotoxin B subunit (LTB), the multimer is a pentamer, and in the chimera the molar ratio between the fusion protein and the mucosal immune adjuvant protein monomer capable of forming multimers is 1:4. In the present invention, a characteristic that a mucosal immune adjuvant protein can form a pentamer is used to form a chimeric structure, so as to form an antigen having a higher potency. Moreover, a mucosal immune adjuvant protein is used to improve an immune effect, so as to improve an effect of enhancing antigen immunogenicity.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: December 24, 2019
    Assignee: SHANGHAI UNITED CELL BIOTECHNOLOGY CO., LTD.
    Inventors: Keryin Lee, Yuhong Geng
  • ANTIGEN CHIMERA, ANTIGEN COMPOSITION, VACCINE, METHOD OF PREPARING THE SAME AND CASSETTE THEREOF
    Publication number: 20160368951
    Abstract: The present invention provides an antigen chimera, comprising: a fusion protein of an antigen and a mucosal immune adjuvant protein monomer capable of forming a multimer; and the mucosal immune adjuvant protein monomer capable of forming the multimer; wherein the mucosal immune adjuvant protein monomer capable of forming the multimer is one selected from cholera toxin B subunit (CTB) and E. coli heat-labile enterotoxin B subunit (LTB), the multimer is a pentamer, and in the chimera the molar ratio between the fusion protein and the mucosal immune adjuvant protein monomer capable of forming multimers is 1:4. In the present invention, a characteristic that a mucosal immune adjuvant protein can form a pentamer is used to form a chimeric structure, so as to form an antigen having a higher potency. Moreover, a mucosal immune adjuvant protein is used to improve an immune effect, so as to improve an effect of enhancing antigen immunogenicity.
    Type: Application
    Filed: July 30, 2014
    Publication date: December 22, 2016
    Applicant: SHANGHAI UNITED CELL BIOTECHNOLOGY CO., LTD.
    Inventors: Keryin LEE, Yuhong GENG