Abstract: An antibody-drug conjugate (ADC) or a pharmaceutically acceptable salt thereof, is provided. The ADC includes a tetravalent monoclonal antibody conjugated to a cytotoxic drug by a chemical linker. The monoclonal antibody includes two long chains and four short chains. Each of the long chains includes a first segment and a second segment, the first segment located proximal to the N-terminus of the long chain, and the second segment located proximal to the C-terminus of the long chain. Each of the first segment and second segment pairs with one of the short chains to form an antigen-binding fragment domain, therefore forming four antigen-binding fragment domains having specificity toward the same antigen. Pharmaceutical composition including the ADC and methods of treating diseases using the compositions are also provided.

Abstract: An isolated IgG antibody includes two identical heavy chains each having a hinge region with an amino acid sequence containing an additional cysteine upstream of the two cysteines in the CPPCP sequence of a native IgG hinge region, and a CH1 domain containing a cysteine at the position of 142 according to the IMGT numbering scheme. ADCs based on the antibody having this architecture are also provided.

Abstract: A shooting method comprising the steps of: defining at least two sub-regions on a shot picture; using the at least two sub-regions as color temperature reference regions to conduct white balance adjustment and shoot photographs; determining a color temperature reference region selected on a shot photograph; and calling out a photograph obtained by shooting after white balance adjustment according to the selected color temperature reference region from the shot photographs and displaying same, so that it is realized that photographs are shot first and then white balance adjustment is conducted thereon. Although photographs are shot first and then white balance adjustment is conducted thereon, in fact, many photographs have been obtained after independent white balance adjustment is conducted when the photographs are shot. Therefore, embodiments may accurately restore a previous white balance effect in a shooting environment after the color temperature reference regions are selected afterwards.

Abstract: A shooting method comprising the steps of: defining at least two sub-regions on a shot picture; using the at least two sub-regions as colour temperature reference regions to conduct white balance adjustment and shoot photographs; determining a colour temperature reference region selected on a shot photograph; and calling out a photograph obtained by shooting after white balance adjustment according to the selected colour temperature reference region from the shot photographs and displaying same, so that it is realized that photographs are shot first and then white balance adjustment is conducted thereon. Although photographs are shot first and then white balance adjustment is conducted thereon, in fact, many photographs have been obtained after independent white balance adjustment is conducted when the photographs are shot. Therefore, embodiments may accurately restore a previous white balance effect in a shooting environment after the colour temperature reference regions are selected afterwards.

Abstract: The disclosure includes a method of screening for, diagnosing or detecting non-small cell lung carcinoma or an increased likelihood of developing non-small cell lung carcinoma in a subject. The method comprises: (a) determining the level of at least one biomarker in a test sample from the subject wherein the at least one biomarker is selected from the biomarkers set out in Table 2, 4A, 4B, 6 and/or 7; and (b) comparing the level of the at least one biomarker in the test sample with a control; wherein detecting a difference in the level of the at least one biomarker in the test sample compared to the control is indicative of whether the subject has or does not have non-small cell lung carcinoma or an increased likelihood of developing non-small cell lung carcinoma.