Abstract: An isolated IgG antibody includes two identical heavy chains each having a hinge region with an amino acid sequence containing an additional cysteine upstream of the two cysteines in the CPPCP sequence of a native IgG hinge region, and a CH1 domain containing a cysteine at the position of 142 according to the IMGT numbering scheme. ADCs based on the antibody having this architecture are also provided.

Abstract: In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A method for evaluating performance of a speech enhancement algorithm includes: acquiring a first speech signal including noise and a second speech signal including noise, wherein the first speech signal is acquired from a near-end audio acquisition device close to a sound source, the second speech signal is acquired from a far-end audio acquisition device far from the sound source, and the near-end audio acquisition device is closer to the sound source than the far-end audio acquisition device; acquiring a pseudo-pure speech signal based on the first speech signal and the second speech signal, as a reference speech signal; enhancing the second speech signal by using a preset speech enhancement algorithm, to obtain a denoised speech signal to be tested; and acquiring a correlation coefficient between the reference speech signal and the speech signal to be tested, for evaluating the speech enhancement algorithm.

Abstract: A method for evaluating performance of a speech enhancement algorithm includes: acquiring a first speech signal including noise and a second speech signal including noise, wherein the first speech signal is acquired from a near-end audio acquisition device close to a sound source, the second speech signal is acquired from a far-end audio acquisition device far from the sound source, and the near-end audio acquisition device is closer to the sound source than the far-end audio acquisition device; acquiring a pseudo-pure speech signal based on the first speech signal and the second speech signal, as a reference speech signal; enhancing the second speech signal by using a preset speech enhancement algorithm, to obtain a denoised speech signal to be tested; and acquiring a correlation coefficient between the reference speech signal and the speech signal to be tested, for evaluating the speech enhancement algorithm.

Abstract: In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Embodiments of the present invention provide a method for creating network devices, where the method includes: creating multiple virtual hardware systems of control planes on a hardware system of a control plane of a physical network device; creating multiple virtual hardware systems of forwarding planes on a hardware system of a forwarding plane of the physical network device; loading multiple software systems of the control planes to the multiple virtual hardware systems of the control planes, respectively; loading multiple software systems of the forwarding planes to the multiple virtual hardware systems of the forwarding planes, respectively; creating multiple communication channels. In addition, a corresponding apparatus also provided. By using the technical solutions provided by the embodiments of the present invention, multiple virtual network devices can run software systems in different versions.

Abstract: Embodiments of the present invention provide a method for creating network devices, where the method includes: creating multiple virtual hardware systems of control planes on a hardware system of a control plane of a physical network device; creating multiple virtual hardware systems of forwarding planes on a hardware system of a forwarding plane of the physical network device; loading multiple software systems of the control planes to the multiple virtual hardware systems of the control planes, respectively; loading multiple software systems of the forwarding planes to the multiple virtual hardware systems of the forwarding planes, respectively; creating multiple communication channels. In addition, a corresponding apparatus also provided. By using the technical solutions provided by the embodiments of the present invention, multiple virtual network devices can run software systems in different versions.