Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: A cooking appliance includes a base, a cover body pivotally mounted at the base, a pivot spring provided at a pivot connection member between the base and the cover body, and an attraction assembly including a first attraction member provided at the base and a second attraction member provided at the cover body. The first attraction member and the second attraction member are configured to attract each other to lock the cover body to the base.

Abstract: The present application discloses an electric roasting machine, including an outer housing, an inner housing and a heating device which are accommodated in the outer housing, the inner housing is defined between the outer housing and the heating device, and the inner housing cooperates with the heating device to form a heat insulating cavity. The electric roasting machine of the present application has the advantages of good heat insulation effect, less heat loss and high heat utilization rate.

Abstract: A material cleaning device and a cooking appliance. The material cleaning device comprises: a cleaning chamber, an air inlet, a material inlet, and a water inlet being provided on the cleaning chamber, the air inlet, the material inlet, and the water inlet being respectively used for transporting air flows, a material to be cleaned, and water for cleaning the material to the cleaning chamber; and a stirring assembly provided in the cleaning chamber and being capable of rotating in the cleaning chamber under the action of the air streams, so as to stir the material and the water in the cleaning chamber. The material cleaning device drives the stirring assembly to rotate by means of air streams, so as to make the stirring assembly stir the material and the water in the cleaning chamber, thereby implementing automatic cleaning. The material cleaning device features a simple structure, and is easy to use.

Abstract: An electric roasting machine includes an outer housing, a heating device accommodated in the outer housing, and an inner housing between the outer housing and the heating device. A heat insulating cavity is formed between the inner housing and the heating device. A heat dissipating passage is formed between the outer housing and the inner housing.

Abstract: A touch key structure includes a touch panel including a key area at a front side of the touch panel, a circuit board provided behind the touch panel and including a sensing electrode corresponding to the key area, and a conductive medium provided between the key area and the sensing electrode.

Abstract: A cooking utensil (100) includes a pan body (1), a cover body (2), and an induction coil (3). The pan body (1) is provided with a first electromagnetism conductive loop (11) and a first electric conductive heating strip (12) which are connected to form a closed circuit. The cover body (2) is provided with a second electromagnetism conductive loop (21) and a second electric conductive heating strip (22) which are connected to form a closed circuit. The induction coil (3) corresponds to the first electromagnetism conductive loop (11) and the second electromagnetism conductive loop (21).

Abstract: A touch key structure includes a touch panel including a key area at a front side of the touch panel, a circuit board provided behind the touch panel and including a sensing electrode corresponding to the key area, and a conductive medium provided between the key area and the sensing electrode.

Abstract: A cooking appliance includes a base, a cover body pivotally mounted at the base, a pivot spring provided at a pivot connection member between the base and the cover body, and an attraction assembly including a first attraction member provided at the base and a second attraction member provided at the cover body. The first attraction member and the second attraction member are configured to attract each other to lock the cover body to the base.

Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: An electric roasting machine includes an outer housing, a heating device accommodated in the outer housing, and an inner housing between the outer housing and the heating device. A heat insulating cavity is formed between the inner housing and the heating device. A heat dissipating passage is formed between the outer housing and the inner housing.

Abstract: A material cleaning device and a cooking appliance. The material cleaning device comprises: a cleaning chamber, an air inlet, a material inlet, and a water inlet being provided on the cleaning chamber, the air inlet, the material inlet, and the water inlet being respectively used for transporting air flows, a material to be cleaned, and water for cleaning the material to the cleaning chamber; and a stirring assembly provided in the cleaning chamber and being capable of rotating in the cleaning chamber under the action of the air streams, so as to stir the material and the water in the cleaning chamber. The material cleaning device drives the stirring assembly to rotate by means of air streams, so as to make the stirring assembly stir the material and the water in the cleaning chamber, thereby implementing automatic cleaning. The material cleaning device features a simple structure, and is easy to use.

Abstract: An electric roasting machine includes a housing defining a cavity having an upper opening, a heating device installed in the cavity, and a grill located at the opening of the cavity. The grill includes a carrying part extending into the cavity and located in a region covered by thermal radiation of the heating device.

Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: A cooking utensil (100) includes a pan body (1), a cover body (2), and an induction coil (3). The pan body (1) is provided with a first electromagnetism conductive loop (11) and a first electric conductive heating strip (12) which are connected to form a closed circuit. The cover body (2) is provided with a second electromagnetism conductive loop (21) and a second electric conductive heating strip (22) which are connected to form a closed circuit. The induction coil (3) corresponds to the first electromagnetism conductive loop (11) and the second electromagnetism conductive loop (21).

Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and RB are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and RB are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Abstract: The present invention relates to compounds of formula I that are metallo-?-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with ?-lactam antibiotics for overcoming resistance.