Publication number: 20230365632
Abstract: This disclosure related to a group of peptide derivative Omicsynins with antiviral activity against influenza virus and coronavirus. It also related uses of these derivatives, the chemical formula of the peptide derivative Omicsynins is shown in formula (1): R1—R4 are shown in the following table. NO. substituent1 substituent2 substituent3 R1 Basic amino-acid side chains including lysine, histidine, citrulline residues, and etc. R2 —CH(CH3)2, —CH(CH3)CH2CH3 —CH2CH(CH3)2 Neutral amino-acid side chain including tryptophan, serine, threonine, cysteine residues and etc. R3 R3 including tyrosine, lysine, histidine, citrulline residues, and etc. R4 —CH2OH —CHO R4 including —CH2NH2, —CH?NH,— CH?NOH, —COOH, —COOR5 (R5 represents alkyl groups containing 1-3 carbons), -CONH2 and etc.
Type:
Application
Filed:
February 10, 2021
Publication date:
November 16, 2023
Inventors:
Shuyi SI, Bin HONG, Yuhuan LI, Hongmin SUN, Jiandong JIANG, Xingxing LI, Minghua CHEN, Rongmei GAO, Yongsheng CHE, Xin ZHEN, Liyan YU, Hongyu LIU, Ming ZHONG, YeXiang WU, Yuanyuan SHI