Abstract: The present invention provides compositions and methods useful for detecting and treating aggressive prostate cancer. In a specific embodiment, a method for identifying a patient as having aggressive prostate cancer comprises the steps of (a) measuring the concentration of total PSA, free PSA, p2PSA in a serum sample obtained from the patient and calculating phi based on the measured serum concentrations; (b) measuring the concentration of fucosylated PSA (fuc-PSA) in a serum sample obtained from the patient; (c) measuring the concentration in a serum sample obtained from the patient of one or more of the following biomarkers: B7-H3, PLA2G7, GDF-15, IL-6R alpha, SDC1, VCAM-1, s Tie-2, IL-16, CA15-3, MMP-2, and H SP27; and (d) using an algorithm to identify the patient as having aggressive prostate cancer based on a panel of biomarkers comprising phi, fuc-PSA and one or more of the serum concentrations measured in step (c).

Abstract: Provided herein are methods of detecting pancreatic cancer in a subject, the method comprising measuring in a sample from the subject a level of CA19-9 polysaccharide relative to a reference, and a level of a polynucleotide or polypeptide of at least one marker selected from the group consisting of: OPN, MIA, CEACAM-1, MIC-1, SPON1, HSP27, POSTN, and LGALS3BP relative to a reference, wherein an increased level of the CA19-9 polysaccharide relative to a reference and an increased level of the polynucleotide or polypeptide relative to a reference indicates presence of pancreatic cancer in the subject.

Abstract: Provided herein are methods of detecting pancreatic cancer in a subject, the method comprising measuring in a sample from the subject a level of CA19-9 polysaccharide relative to a reference, and a level of a polynucleotide or polypeptide of at least one marker selected from the group consisting of: OPN, MIA, CEACAM-1, MIC-1, SPON1, HSP27, POSTN, and LGALS3BP relative to a reference, wherein an increased level of the CA19-9 polysaccharide relative to a reference and an increased level of the polynucleotide or polypeptide relative to a reference indicates presence of pancreatic cancer in the subject.

Abstract: The scooter of the present invention includes a footboard having a front portion, and a rear portion attached to a rear wheel; a front wheel axle having an upward axis perpendicular with the front wheel axle and a steering axis, wherein the front wheel axle is rotatable with respect to the steering axis; and a plurality of front wheels attached to the front wheel axle. The steering axis forms a predetermined adjacent angle between 0 degree and 90 degree with respect to the upward axis.

Abstract: The scooter of the present invention includes a footboard having a front portion, and a rear portion attached to a rear wheel; a front wheel axle having an upward axis perpendicular with the front wheel axle and a steering axis, wherein the front wheel axle is rotatable with respect to the steering axis; and a plurality of front wheels attached to the front wheel axle. The steering axis forms a predetermined adjacent angle between 0 degree and 90 degree with respect to the upward axis.

Abstract: The scooter of the present invention includes a footboard having a front portion, and a rear portion attached to a rear wheel; a front wheel axle having an upward axis perpendicular with the front wheel axle and a steering axis, wherein the front wheel axle is rotatable with respect to the steering axis; and a plurality of front wheels attached to the front wheel axle. The steering axis forms a predetermined adjacent angle between 0 degree and 90 degree with respect to the upward axis.

Abstract: A programmable lock system is provided for access restricting and user tracking The system includes a lock mechanism, a microcontroller, and an input device for receiving passing information. The microcontroller reads the received passing information and determines whether to unlock the lock mechanism. The system further includes an inlet for receiving an external storage with pre-programmed code. The microcontroller determines whether to access date contained therein base on the pre-programmed code.

Abstract: The scooter of the present invention includes a footboard having a front portion, and a rear portion attached to a rear wheel; a front wheel axle having an upward axis perpendicular with the front wheel axle and a steering axis, wherein the front wheel axle is rotatable with respect to the steering axis; and a plurality of front wheels attached to the front wheel axle. The steering axis forms a predetermined adjacent angle between 0 degree and 90 degree with respect to the upward axis.

Abstract: The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant.

Abstract: A programmable lock system is provided for access restricting and user tracking. The system includes a lock mechanism, a microcontroller, and an input device for receiving passing information. The microcontroller reads the received passing information and determines whether to unlock the lock mechanism. The system further includes an inlet for receiving an external storage with pre-programmed code. The microcontroller determines whether to access data contained therein based on the pre-programmed code.

Abstract: A self-scrambling combination includes a frame that supports at least two tumbler rings and an activating slide. The tumbler rings are marked with characters used for a combination for the lock. The lock is openable only when the tumbler rings are located in an open position related to the combination. The activating slide moves a locking bar between a locked position and an unlocked position. A scrambling mechanism is attached to the activating slide and rotates the tumbler rings from the open position to another position upon movement of the activating slide to move the locking bar from the unlocked position to the locked position. The frame can be used as the door of a lockbox and an attached key lock controls the setting of the combination for the lock. The self-scrambling combination lock can be used for a briefcase or valise lock with an additional spring closing the lock.

Abstract: The present invention discloses a novel system for signaling intrusion of a protected space to a remotely located user. The system includes a lock mechanism and a sensor module that detects an unlocked state of the lock mechanism and in response sends out a signal to a central unit. The central unit then communicates to a remote device that indicates intrusion upon receiving the signal. The central unit and the remote device can be incorporated into one unitary system. Alternatively, the central unit can be integrated within the lock mechanism.

Abstract: The instant invention provides methods and compositions for the detection of prostate cancer in a subject.

Abstract: A reinforced flexible hose that has at least one layer of stainless steel threads braided about the outer surface of the inner core and a transparent flexible polymeric covering located over the braided stainless steel threads, thereby protecting them from abrasion and corrosion. The covering is not in intimate contact with the circumference of each thread thereby trapping pockets of air between the covering and the threads. A moisture sensitive compound is dispersed through the stainless steel threads under the transparent covering. When the compound becomes wet, it changes from a first color to a second color indicating that the hose has failed.

Abstract: A reinforced flexible hose that has at least one layer of stainless steel threads braided about the outer surface of the inner core and a transparent flexible polymeric covering located over the braided stainless steel threads, thereby protecting them from abrasion and corrosion. The covering is not in intimate contact with the circumference of each thread thereby trapping pockets of air between the covering and the threads. A moisture sensitive compound is dispersed through the stainless steel threads under the transparent covering. When the compound becomes wet, it changes from a first color to a second color indicating that the hose has failed.

Abstract: A reinforced flexible hose that has at least one layer of stainless steel threads braided about the outer surface of the inner core and a flexible polymeric covering located over the braided stainless steel threads, thereby protecting them from abrasion and corrosion. The covering is not in intimate contact with the circumference of each thread thereby trapping pockets of air between the covering and the threads. The covering may be transparent.

Abstract: A secure lockbox includes an interior key lock that controls access to the mechanism for setting and changing the combination for the lock controlling access to the interior storage compartment of the lockbox. A second key lock controls the attachment bail of the lockbox, preventing unauthorized removal of the lockbox. The two key locks may be identically keyed. In a variant of the invention, a second combination lock controls the attachment bail instead of a key lock. Resilient coverings are provided for the attachment bail and the sides of the lockbox body to prevent damage to buildings and fixtures. A chain is provided to secure the door of the lockbox to the body. A slide latch having non-slip features is controlled by the door's combination lock and engages an edge of the door opening to secure the door opening. The slide latch may have a protrusion for ease of use.